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Thermoset polyester droplet-based microfluidic devices for high frequency generation
Kim, Jin-young,deMello, Andrew J.,Chang, Soo-Ik,Hong, Jongin,O'Hare, Danny Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.23
<P>The vast majority of droplet-based microfluidic devices are made from polydimethylsiloxane (PDMS). Unfortunately PDMS is not suitable for high frequency droplet generation at high operating pressure due to its low shear modulus. In this paper, we report the fabrication and testing of microfluidic devices using thermoset polyester (TPE). The optical characteristics of the fabricated devices were assessed and substrate resistance to pressure also investigated. TPE devices bonded using an O<SUB>2</SUB> plasma treated PET substrate at 76 °C were shown to function efficiently at pressures up to 18 MPa. TPE material retains many of the attractive features of PDMS such as ease of fabrication but significantly, has superior mechanical properties. The improved resistance of TPE to high pressures enabled investigation of high frequency droplet generation as a function of a wide range of flow-rates with three different oils as continuous phase.</P> <P>Graphic Abstract</P><P>Droplet-based microfluidic devices to withstand high pressure have been successfully fabricated using thermoset polyester (TPE) materials for high frequency generation of droplets. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1lc20603f'> </P>
( Raphael Trouillon ),( Danny O`hare ),( Soo Ik Chang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.11
Nitric oxide (NO) is a critical biological mediator involved in numerous diseases. However, the short lifetime of this molecule in biological conditions can make its study in situ complicated. Here, we review some recent results on the role of NO in angiogenesis, obtained using a biocompatible microelectrode array. This simple system allowed for the quick and easy quantification of NO released from cells grown directly on the surface of the sensor. We have used this technology to demonstrate that angiogenin induces NO release, and to partially elucidate its intracellular transduction pathway. [BMB reports 2011; 44(11): 699-704]
Monolithic nano-porous polymer in microfluidic channels for lab-chip liquid chromatography
Kim Jin-young,O’Hare Danny 나노기술연구협의회 2018 Nano Convergence Vol.5 No.19
In this paper, a nano-porous polymer has been integrated into the microfluidics device as on-chip monolithic liquid chromatography column for separation of chemical and biological samples. Monolithic nano-porous polymer (MNP) was formed and firmly grafted on the surface of the microfluidic channel. Neurotransmitters, 5-hydroxyindole-3-acetic acid (5-HIAA) and 5-hydroxytryptamine (serotonin, 5-HT), were successfully separated with the developed on-chip MNP column.
Kim Jin-young,Chang Soo-Ik,deMello Andrew J,O’Hare Danny 나노기술연구협의회 2014 Nano Convergence Vol.1 No.3
In this paper, a porous polymer nanostructure has been integrated with droplet-based microfluidics in a single planar format. Monolithic porous polymer (MPP) was formed selectively within a microfluidic channel. The resulting analyte bands were sequentially comartmentalised into droplets. This device reduces band broadening and the effects of post-column dead volume by the combination of the two techniques. Moreover it offers the precise control of nano/picoliter volume samples. Background
Angiogenin induces nitric oxide release independently from its RNase activity
Trouillon, Raphaë,l,Kang, Dong-Ku,Chang, Soo-Ik,O'Hare, Danny Royal Society of Chemistry 2011 Chemical communications Vol.47 No.12
<P>Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.</P> <P>Graphic Abstract</P><P>Angiogenin induced NO release was sensed electrochemically using a microelectrode array. This phenomenon is independent from angiogenin RNase activity. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc04527f'> </P>
Development of inlaid electrodes for whole column electrochemical detection in HPLC
Seo, Jung-Ho,Leow, Pei Ling,Cho, Si-Hyeong,Lim, Hyun-Woo,Kim, Jin-Young,Patel, Bhavik Anil,Park, Jin-Goo,O'Hare, Danny Royal Society of Chemistry 2009 Lab on a chip Vol.9 No.15
<P>An electrochemical microfluidic device has been fabricated on PET (polyethylene terephthalate) substrate using an imprinting method. The imprinting transfers patterns from a stamp into a substrate mechanically. However, a blanket mould imprinting process has been introduced to embed the photolithographically produced gold metal electrode lines into the PET substrate resulting in an individually addressable array flush to better than 100 nm. The device formed one wall of a packed chromatography column. The array was electrochemically characterised using standard redox probes in both stagnant conditions and under flow. Both numerical modelling and experimental data show improved sensitivity under flow and a limiting current which scaled linearly with the cube root of the volume flow rate. A chromatographic separation of the bioanalytical significant neurotransmitter dopamine (DA) and its metabolite DOPAC was achieved and electrochemically detected at multiple locations within the column. The PET device was stable and robust to leaks to pressures well in excess of those required for chromatographic separations.</P> <P>Graphic Abstract</P><P>An electrochemical microfluidic device has been fabricated on a PET substrate using an imprinting method. The imprinting transfers patterns from a stamp into a substrate mechanically. Inlaid microelectrodes were successfully fabricated within a LC column which allows electrochemical detection of analytes. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b822045j'> </P>