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      • Apoptosis in Rheumatoid Arthritis Novel Pathway in Regulation of Autoimmune Disease

        Nishioka, Kusuki 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-

        Rheumatoid arthritis(RA) has been characterized by proliferating synoviym and influx of variety of inflammatory cells. According to the disease progression the prcess involving hyperplasia of synovial cell. mainly involving synovial fibroblasts and developing bone and joint destruction. However, one of the characteristic features RA, proliferation of synovium is not limitless and spontaneous growth arrest of synovial hypertrophy has been occasionally observed in the course of the disease. This clinical feature has been obscure and considered as "natural course" of the disease progression in RA for long time. This paradoxical phenomena has been divided into following process. One is "spontaneous remission" and the other is, intractable proliferated synovium which leads bone destruction. These clinical characteristics of RA prompted us to investigate how alteration of rheumatoid synovium occurs, i. e.. cell cycle alteration or somatic gene mutation arrest. Apoptosis has been recognized a mode of cell death in which cell are deleted in the midst of living tissue. Despite of other form of death. such as necrosis, apoptosis rightly associated with homeostasis in vertebrate differentiation and proliferation as well.

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