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RISS 인기검색어
- 검색키워드
- 저자 : Neela M. Bhatia (검색결과 2 건)
- 무료
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Sachin S. Salunkhe,Neela M. Bhatia,Varsha B. Pokharkar,Jyoti D. Thorat,Manish S. Bhatia 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.4
The objective of present study was to develop nanostructured lipid carriers (NLC) for topical delivery of antioxidant drug and evaluation of its sun protection efficacy. In the present study attempts have been made to formulate Idebenone loaded nanostructured lipid carriers (INLC) by using solvent precipitation method. Preformulation study evidenced for selection of Captex 500 P as an oil phase in which Idebenone has saturation solubility of 0.266 ±0.032 g/ml. Compritol 888 ATO and ethanol were selected as solid lipid and solvent respectively. Surfactant and cosurfactant as Labrasol and Transcutol P have given stable formulations on the basis of HLB required for stabilization,respect to oil phase. INLC has particle size of 605 ±4.01 nm and %EE of 82.58 ± 2.20 %. Optimized batches were subjected for crystallographic investigation, in vitro skin permeation study, drug deposition study, SPF determination and antioxidant activity. XRD, DSC studies illustrated that partial amorphization of Idebenone by molecularly dispersion within lipid blend leads for entrapment of drug. Permeation data showed that optimized INLC has flux value (Jss)of 7.87 lg cm-2 h-1. High significance (P\0.001) of drug deposition in skin was observed between INLC and plain Idebenone gel. SPF value for INLC has 23which represents that lipid nanocarriers have standards of blocking of 94–96 % of UVB rays. Such high skin deposition and SPF leads to more antioxidant effect of formulations. Hence lipid nanocarriers such as NLC have potential as an antioxidant and sun protection for topical drug delivery.
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Sachin S. Salunkhe,Neela M. Bhatia,Jyoti D. Thorat,Prafulla B. Choudhari,Manish S. Bhatia 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4
The objective of this study was to optimizeibuprofen loaded nanoemulsion by using a factorial designapproach. In the present study attempts have been made toformulate and evaluate nanoemulsion for topical deliveryof ibuprofen. Solvent precipitation technique was used fordevelopment of ibuprofen nanoemulsion. Miglyol 840 wasscreened as the oil phase due to a good solubilisationcapacity (0.197 ± 0.012 g/mL) for ibuprofen. On the basisof RHLB of an oil phase Labrasol and Triton X 100 wereused as surfactant and cosurfactant, respectively. The studyinvestigated the utility of 23 factorial design for optimizationprocess of nanoemulsion batches. Present modeldemonstrated the significance of factors such as drugconcentration (X1), anti-solvent volume (X2) and surfactantcosurfactant combination concentration (X3) on particlesize (Y1) and encapsulation efficiency (Y2). Optimizednanoemulsion showed better flux value (Jss), skin permeationcoefficient (Kp) as compared to plain ibuprofen gel. Drug deposition study revealed that optimized ibuprofennanoemulsion showed deposition of 26.13 ± 3.47 lg cm-2in comparison to the deposition of 16.50 ± 2.34 lg cm-2shown by plain ibuprofen loaded gel. While the antiinflammatorystudy has shown faster onset of action withthe nanoemulsion which was confirmed by 75 ± 1.27 %inhibition of inflammation at the end of 1 h and63.97 ± 1.71 % at the end of 24 h. The effect of drug wasenhanced by prepared nanoemulsion formulation andhence confirms the utility of nanoemulsion system as avehicle for better topical delivery of ibuprofen.
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