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RISS 인기검색어
- 검색키워드
- 저자 : Nazarnezhad, Mirzaali (검색결과 3 건)
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A novel hydrogel containing 4-methylcatechol for skin regeneration: in vitro and in vivo study
Jilla Majidi Ghatar,Arian Ehterami,Simin Nazarnezhad,Maryam Sadat Hassani,Nariman Rezaei Kolarijani,Solmaz Mahami,Majid Salehi 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.3
Skin damages are usual physical injuries and different studies have been done to improve wound healing. Hydrogel dueto its properties like a moist environment and cooling wound site is a good option for wound treatment. In this study, weevaluated the consequence of using alginate/chitosan hydrogel contained various dosages of 4-Methylcatechol (0, 0.1, 1%(W/W)) on wound healing. After hydrogel fabrication, different tests like SEM, swelling, release, weight loss, and hemoandcytocompatibility were done to characterize fabricated hydrogels. Finally, the rat model was used to assess Alginate/Chitosan hydrogel's therapeutic function containing 0.1 and 1% of 4-Methylcatechol. The pore size of hydrogel was between24.5 ± 9 and 62.1 ± 11.63 μm and about 90% of hydrogel was lost after 14 days in the weight loss test. Blood compatibilityand MTT assay showed that hydrogels were nontoxic and improved cell proliferation. In vivo test showed that Alginate/Chitosan/0.1%4-Methylcatechol improved wound healing and the results were significantly better than the gauze-treatedwound. Our results showed dose depending effect of 4-Methylcatechol on wound healing. This study shows the treatmenteffect of 4-Methylcatechol on wound healing and the possibility of using it for treating skin injuries.
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Majid Salehi,Maryam Niyakan,Arian Ehterami,Saeed Haghi-Daredeh,Simin Nazarnezhad,Ghasem Abbaszadeh-Goudarzi,Ahmad Vaez,Seyedeh Fatemeh Hashemi,Nariman Rezaei,Seyed Reza Mousavi 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
In this study, cinnamon (cin) was loaded into poly(ε-caprolactone)/gelatin (PCL/Gel) nanofi brous matrices in order to fabricatean appropriate mat to improve wound healing. Mats were fabricated from PCL/COLL [1:1 (w/w)] solution with 1, 5and 25% (w/v) of cinnamon. Prepared mats were characterized with regard to their microstructure, mechanical properties,porosity, surface wettability, water-uptake capacity, water vapor permeability, blood compatibility, microbial penetration andcellular response. The fabricated mats with and without cinnamon were used to treat the full-thickness excisional wounds inWistar rats. The results indicated that the amount of cinnamon had a direct eff ect on porosity, mechanical properties, wateruptake capacity, water contact angle, water vapor transmission rate and cell proliferation. In addition, the results of in vivostudy indicated that after 14 days, the wounds which were treated with PCL/Gel 5%cin had better wound closure (98%)among other groups. Our results suggest that the cinnamon can be used as a suitable material for wound healing.
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Blood Malignancies in Mazandaran Province of Iran
Tahmasby, Bahram,Marnani, Ahmad Barati,Maleki, Mohammadreza,Barouni, Mohsen,Mousavi, Seyyed Hamid,Naseriyan, Behjat,Nazarnezhad, Mirzaali,Alizadeh, Ali,Sabermahani, Asma Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: Leukemia and lymphoma demonstrate significantly incidence rates throughout the world and particularly in Iran they cause serious mortality and diagnosis and treatment expenditures for both families and the health system. Combined they account for about 11 percent of cancers in Mazandaran province, ranking number 2 in prevalent cancers. The purpose of this study was to provide a first general and specific description of leukemia and lymphoma in Mazandaran province. Materials and Methods: In this descriptive retrospective study, entire patient's data were reviewed which had confirmed diagnosis of leukemia and lymphoma with valid laboratory or pathology reports in the period 2001-2008. The data were collected by Babol health research site related to Tehran University of Medical Science. Incidence rates based on age groups, gender, city of residence and type of malignancy were calculated and analyzed. Results: In Mazandaran province, 1,146 cases of leukemia and lymphoma were encountered, 5.9 in 100,000 persons on average annually. The highest incidence rates were obtained at age of 70 or above (26.4) and the lowest at age of 0-9 (2.3).The incidence rates in males and females were 7.1 and 4.8 respectively with a ratio of 1.5. The highest incidence rate was in Babol (7.3) and the lowest was calculated in Neka and Tonekabon equally (1.5). According to the type of malignancy, non Hodgkin lymphoma, with 2.5/100,000 have the most incidence rate and myeloid leukemia with 1.8 had the lowest. Conclusions: The obtained findings indicate clear differences in incidence rates based on age, gender, residence, and type of malignancy. Therefore it's suggested that in addition to promote data collecting programs, research projects should be programmed to define leukemia and lymphoma risk factors in this province.
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