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RISS 인기검색어
- 검색키워드
- 저자 : Naseer Ahmed (검색결과 5 건)
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Indigenous Radiosynthesis of [131I]Iodobenzylguanidine ([131I]mIBG) for Neuroblastoma Imaging
Nadeem Ahmed Lodhi,Muhammad Irfan,Muhammad Nasir Saddique,Kahkshan Bashir Mir,Naseer Ahmed,Shazia Fatima,Mumtaz Khan,Muhammad Wasim,Samina Roohi 대한방사성의약품학회 2022 Journal of radiopharmaceuticals and molecular prob Vol.8 No.2
Indigenous diagnostic dose of 131I-labeled meta-iodobenzylguanidine ([131I]mIBG) was prepared via Cu+ catalyzed isotope exchange reaction generated in situ by sodium metabisulfite for imaging of neuroblastoma tumor. [131I]mIBG was produced in overall 85-90% radiochemical yield. The average amount of radioactivity of [131I]mIBG was 2164 MBq (1998-2331MBq) with an average specific activity > 1000 MBq/mg at the end of synthesis. The radiochemical purity was ≥ 99.9% after purification through Dowex-1 × 8 ion exchange resin (100-150 mesh) at the date of preparation. The stability of [131I]mIBG at concentration 480-555 MBq/mL was > 97% at 4 °C after 4 days. The room temperature (25 °C) stability of [131I]mIBG was > 98% after 24 h. Biodistribution of [131I]mIBG in patient showed uptake in salivary glands, liver, spleen and excreted though urinary bladder. Neuroendocrine medicated uptake into tumor lesion and metastatic sites were noted which strongly correlate with the morphological abnormalities of patient.
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Coating Performance of SiO2/ Epoxy Composites as a Corrosion Protector
Naseer Alhaboubi,Dina R. Rzaij,Nagham Y. Ahmed 한국부식방식학회 2022 Corrosion Science and Technology Vol.21 No.2
To solve the corrosion problem of industrial equipment and other constructions containing metals, corrosion protection can be performed by using coating which provides a barrier between the metal and its environment. Coatings play a significant role in protecting irons and steels in harsh marine and acidenvironments. This study was conducted to identify an anti-corrosive epoxy coating for carbon steel composite with 0.1, 0.3, and 0.5 wt% concentrations of nanoparticles of SiO2 using the dip-coating method. The electrochemical behavior was analyzed with open circuit potential (OCP) technics and polarization curves (Tafle) in 3.5 wt% NaCl and 5 vol% H2SO4 media. The structure, composition, and morphology were characterized using different analytical techniques such as X-ray Diffraction (XRD), Fourier Transform Infrared spectrum (FT-IR), and Scanning Electron Microscopy (SEM). Results revealed that epoxynano SiO2 coating demonstrated a lower corrosion rate of 2.51 × 10-4 mm/year and the efficiency of corrosion protection was as high as 99.77%. The electrochemical measurement showed that the nano-SiO2 / epoxy coating enhanced the anti-corrosive performance in both NaCl and H2SO4 media.
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Naseer, Muhammad Imran,Ullah, Ikram,Al-Qahtani, Mohammed H,Karim, Sajjad,Ullah, Najeeb,Ansari, Shakeel Ahmed,Kim, Myeong Ok,Bibi, Fehmida Springer-Verlag Italia 2013 Neurological sciences Vol.34 No.4
<P>The objective of this study was to evaluate the PTZ-induced seizures effects on GABAB receptor (R) expression and to observe its neurodegenerative effect in hippocampal part of developing rat brain. In the present study, high dose of pentylenetetrazol (PTZ 40 mg/kg) was injected in developing rats of age 5 weeks having average weight of 60-65 g for 4 days. Further, baclofen (B 3 mg/kg i.p) agonist and phaclofen (P 30 μg/rat) antagonist of GABABR were injected along with PTZ. Western blot analysis was used to elucidate expression of GABABR protein upon PTZ, baclofen and phaclofen exposure in the developing rat brain. Furthermore, PTZ-induced apoptotic neurodegeneration was also observed through the release of caspase-3 antibody and propidium iodide (PI) staining using confocal microscopy. Seizure was confirmed using electroencephalography (EEG) data obtained from the Laxtha EEG-monitoring device in the EEG recording room and EEG was monitored 5-15 min after PTZ injection. The results of the present study showed that PTZ-induced seizure significantly decreased GABABR expression and induced neuronal apoptosis in cortical and hippocampal part of brain. While, baclofen reverse the effect of PTZ by increasing the expression of GABABR as compared to the PTZ- , PTZ plus B- and PTZ plus P-treated groups. Our findings indicated that PTZ-induced seizure showed not only decrease in GABABR expression but also cause neuronal apoptosis in the developing rat brain.</P>
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Ullah, Najeeb,Ullah, Ikram,Lee, Hae Young,Naseer, Muhammad Imran,Seok, Park Moon,Ahmed, Jawad,Kim, Myeong Ok Birkhäuser Boston 2012 Journal of molecular neuroscience Vol.47 No.1
<P>During development, anesthetics activate neuroapoptosis and produce damage in the central nervous system that leads to several types of neurological disorders. A single dose of ketamine (40?mg/kg) during synaptogenesis in a 7-day-old rat brain activated the apoptotic cascade and caused extensive neuronal cell death in the forebrain. In this study, we investigated the protective effect of nicotinamide against ketamine-induced apoptotic neurodegeneration. After 4?h, neuronal cell death induced by ketamine was associated with the induction of Bax, release of cytochrome c into the cytosol, and activation of caspase-3. One single dose of 1?mg/g nicotinamide was administered to a developing rat and was found to inhibit ketamine-induced neuroapoptosis by downregulating Bax, inhibiting cytochrome c release from mitochondria into cytosol, and inhibiting the expression of activated caspase-3. TUNEL and immunohistochemical analyses showed that ketamine-induced cell death occurred through apoptosis and that it was inhibited by nicotinamide. Fluoro-Jade-B staining demonstrated an increased number of dead cells in the cortex and thalamus after ketamine treatment; treatment with nicotinamide reduced the number of dead cells in these brain regions. Our findings suggest that nicotinamide attenuated ketamine-induced neuronal cell loss in the developing rat brain and is a promising therapeutic and neuroprotective agent for the treatment of neurodevelopmental disorders.</P>
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Corrosion and wear behavior of TiN PVD coated 304 stainless-steel
Awais Awan,Riffat Asim Pasha,Muhammad Shoaib Butt,Rizwan Ahmed Malik,Ibrahim M Alarifi,Meshal Alzaid,무하마드 라티프,Ammar Naseer,Mohsin Saleem,Hussein Alrobei 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.8
Ti/TiN multilayered physical vapor deposition (PVD) coatings were deposited on stainless-steel by cathodic arc deposition method. Bare sample of stainless steel 304 was compared with monolithic TiN coating and TiN coating having 2, 4, 6 and 8 Ti interlayers. The properties like corrosion and wear resistance were studied and analyzed comparatively. Potentiodynamic polarization curves showed that highest corrosion resistance was indicated by TiN coating with 8 Ti interlayers. Sample having 8 Ti interlayers have high corrosion potential (E corr ) and low corrosion current density (I corr ) as compared to other samples. This may be attributed to the arrangement of interlayers that prevents the corrosive agents to penetrate surface. All multilayered coatings show better results than the substrate material. Pin on disk wear test revealed that coating having monolithic TiN layer have the lowest coefficient of friction and consequently have less wear volume and wear rate as compared to other coatings with Ti interlayers. These results made the investigated coated stainless steel 304 valuable for wide range of industrial applications that required wear and corrosion resistance.
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