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Kaushik, Nagendra Kumar,Kaushik, Neha,Min, Booki,Choi, Ki Hong,Hong, Young June,Miller, Vandana,Fridman, Alexander,Choi, Eun Ha IOP 2016 Journal of Physics. D, Applied Physics Vol.49 No.8
<P>The present study aims at studying the anticancer role of cold plasma-activated immune cells. The direct anti-cancer activity of plasma-activated immune cells against human solid cancers has not been described so far. Hence, we assessed the effect of plasma-treated RAW264.7 macrophages on cancer cell growth after co-culture. In particular, flow cytometer analysis revealed that plasma did not induce any cell death in RAW264.7 macrophages. Interestingly, immunofluorescence and western blot analysis confirmed that TNF-<I>α</I> released from plasma-activated macrophages acts as a tumour cell death inducer. In support of these findings, activated macrophages down-regulated the cell growth in solid cancer cell lines and induced cell death <I>in vitro</I>. Together our findings suggest plasma-induced reactive species recruit cytotoxic macrophages to release TNF-<I>α</I>, which blocks cancer cell growth and can have the potential to contribute to reducing tumour growth <I>in vivo</I> in the near future.</P>
Biological and medical applications of plasma-activated media, water and solutions
Kaushik, Nagendra Kumar,Ghimire, Bhagirath,Li, Ying,Adhikari, Manish,Veerana, Mayura,Kaushik, Neha,Jha, Nayansi,Adhikari, Bhawana,Lee, Su-Jae,Masur, Kai,von Woedtke, Thomas,Weltmann, Klaus-Dieter,Choi De Gruyter 2019 Biological chemistry Vol.400 No.1
<P><B>Abstract</B></P><P>Non-thermal atmospheric pressure plasma has been proposed as a new tool for various biological and medical applications. Plasma in close proximity to cell culture media or water creates reactive oxygen and nitrogen species containing solutions known as plasma-activated media (PAM) or plasma-activated water (PAW) - the latter even displays acidification. These plasma-treated solutions remain stable for several days with respect to the storage temperature. Recently, PAM and PAW have been widely studied for many biomedical applications. Here, we reviewed promising reports demonstrating plasma-liquid interaction chemistry and the application of PAM or PAW as an anti-cancer, anti-metastatic, antimicrobial, regenerative medicine for blood coagulation and even as a dental treatment agent. We also discuss the role of PAM on cancer initiation cells (spheroids or cancer stem cells), on the epithelial mesenchymal transition (EMT), and when used for metastasis inhibition considering its anticancer effects. The roles of PAW in controlling plant disease, seed decontamination, seed germination and plant growth are also considered in this review. Finally, we emphasize the future prospects of PAM, PAW or plasma-activated solutions in biomedical applications with a discussion of the mechanisms and the stability and safety issues in relation to humans.</P>
Plasma bioscience for medicine, agriculture and hygiene applications
최은하,Kaushik NAgendra Kumar,Hong Young June,임준섭,최진성,한인 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.8
Nonthermal biocompatible plasma (NBP) sources operating in atmospheric pressure environments and their characteristics can be used for plasma bioscience, medicine, and hygiene applications, especially for COVID-19 and citizen. This review surveyed the various NBP sources, including a plasma jet, micro-DBD (dielectric barrier discharge) and nanosecond discharged plasma. The electron temperatures and the plasma densities, which are produced using dielectric barrier discharged electrode systems, can be characterized as 0.7 ~ 1.8 eV and (3–5) × 1014– 15 cm− 3, respectively. Herein, we introduce a general schematic view of the plasma ultraviolet photolysis of water molecules for reactive oxygen and nitrogen species (RONS) generation inside biological cells or living tissues, which would be synergistically important with RONS diffusive propagation into cells or tissues. Of the RONS, the hydroxyl radical [OH] and hydrogen peroxide H2O2 species would mainly result in apoptotic cell death with other RONS in plasma bioscience and medicines. The diseased biological protein, cancer, and mutated cells could be treated by using a NBP or plasma activated water (PAW) resulting in their apoptosis for a new paradigm of plasma medicine.
Effects of Atmospheric-pressure Non-thermal Plasma Jets on Enzyme Solutions
Pankaj Attri,Pannuru Venkatesu,Kaushik NAgendra Kumar,Yong Gyu Han,Chul Joo Nam,최은하,김기선 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.6
In order to study the wide scope of structural information of biomolecules in the presence of biocompatible cold atmospheric pressure plasma jets (CAPJ), we used circular dichroism (CD) and fluorescence experiments. Biomolecules are very sensitive and are highly complex systems, exhibiting a substantial degree of structural variability in their folded state. In the present investigation, we compared the compatiblity of -chymotrypsin (CT) in the presence of biocompatible CAPJ. Using circular dichroism (CD) and fluorescence experiments, we describe the associated structural changes in CT after a 5 min treatment with CAPJ. The modifications in the secondary structure of this β/β protein were quantified by using the CD spectra. A reasonable decrease was observed for β-strands after treatment with CAPJ as compared to buffer, which contributes to its deterioration power. The implications of our results from studies delineating the effects of CAPJ on enzyme solutions are discussed.
Plasma-assisted fabrication of manganese oxide-gold hybrid nanoparticles
Linh Nhat Nguyen,Nagendra Kumar Kaushik,Eun Ha Choi 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
In this study, we design hybrid nanoparticles of Manganese oxide- gold (MnO<sub>2</sub>-Au), which possesses enzyme-like characteristics of GOx (MnO<sub>2</sub>) and CAT (AuNPs) by using plasma-assisted synthesis method. Cold atmospheric plasma triggers the chemical reactions that lead to the formation of the MnO<sub>2</sub>-Au NPs. The manganese dioxide (MnO<sub>2</sub>) would react with H<SUB>2</SUB>O<SUB>2</SUB> and acid to generate O<sub>2</sub>. Meanwhile, the generated O<sub>2</sub> can be further consumed by GOx-like AuNPs to decompose glucose and produce H<SUB>2</SUB>O<SUB>2</SUB> again. The plasma-synthesized MnO<sub>2</sub>-Au NPs is a potential candidate for starvation therapy.