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Synthesis, analgesic and anti-inflammatory activities of novel mannich bases of benzimidazoles
Neeraj Kumar,C. S. Sharma,M. S. Ranawat,H. P. Singh,L. S. Chauhan,N. Dashora 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.1
A series of novel mannich bases of 2-substituted benzimidazoles was synthesized by the reaction of 2-substituted benzimidazoles with corresponding aldehyde and acetophenones. The structures of all synthesized compounds were confirmed by elemental analysis, IR, ¹HNMR,¹³C-NMR and LCMS. The compounds were evaluated for in vivo analgesic and in vivo anti-inflammatory activities by a tail flick method and carrageenan-inducedrat paw edema test respectively. Among all the compounds synthesized, compound A1 and B3 exhibited significantanalgesic and anti-inflammatory activities. Acute ulcerogenicity studies showed that compound A1 and B3 were devoid of gastrointestinal toxicities.