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RISS 인기검색어
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- 저자 : My El Abbes Faouzi (검색결과 2 건)
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Ilias Marmouzi,El Mostafa Karym,Rachid Alami,Meryem El Jemli,Mourad Kharbach,Fouzia Mamouch,Aisha Attar,Bouchra Faridi,Yahia Cherrah,My El Abbes Faouzi 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.2
Therapy combination is known for less side effects and higher efficacy. Essential oils (EOs) and mixture from two wellknown plants (Syzygium aromaticum and Pelargonium graveolens) were tested for in vivo antioxidant and anti-inflammatory activities. The chemical analysis of the investigated Oils has lead to the identification of Eugenol (74.06%), Caryophyllene (11.52%) and Carvacrol acetate (7.82%) as the major element in S. aromaticum; while P. graveolens was much higher in Citronellol (30.77%), 10-epi-γ-Eudesmol (22.59%), and Geraniol (13.95%). In our pharmacological screening, both EOs demonstrated good antioxidant effects; especially S. aromaticum activity was much higher. In contrast, the in vivo investigation of the antioxidant activity using antioxidant enzymes (MDA, SOD and CAT) in the protozoa model (Tetrahemena pyriformis) demonstrated a higher protective effect of P. graveolens and EOs mixture. On the other hand, EOs demonstrated anti-inflammatory effect on the two phases of inflammation in the carrageenan induced edema model. Results from this study indicate that EOs from S. aromaticum and P. Graveolens can be used as a multitarget therapy.
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Investigation of Antioxidant, Hypoglycemic and Anti-Obesity Effects of Euphorbia Resinifera L.
Benrahou Kaoutar,Guourrami Otman El,Mrabti Hanae Naceiri,Cherrah Yahia,Faouzi My El Abbes 대한약침학회 2022 Journal of pharmacopuncture Vol.25 No.3
Objectives: The aim of this work is to evaluate the in vitro antioxidant, hypoglycemic, and antiobesity effects of Euphorbia resinifera extracts and investigate the phenolic constituents and the toxicity of these extracts. Methods: Phytochemical screening was performed to detect polyphenols and flavonoids. Antioxidant activity was evaluated by four methods (DPPH, ABTS, H 2 O 2 , and xanthine oxidase inhibition). The hypoglycemic effect was determined by the inhibition of α-amylase and α-glucosidase enzymes in vitro and via a starch tolerance study in normal rats. The antiobesity effect was estimated by in vitro inhibition of lipase. Results: Phytochemical screening revealed that the ethanolic extract was rich in polyphenols (99 ± 0.56 mg GEA/g extract) and tannins (55.22 ± 0.17 mg RE/g extract). Moreover, this extract showed higher antioxidant activity in different tests: the DPPH assay (IC 50 = 53.81 ± 1.83 µg/mL), ABTS assay (111.4 ± 2.64 mg TE/g extract), H 2 O 2 (IC 50 = 98.15 ± 0.68 µg/mL), and xanthine oxidase (IC 50 = 10.26 ± 0.6 µg/mL). With respect to hypoglycemic effect, the aqueous and ethanolic extracts showed IC 50 values of 119.7 ± 2.15 µg/mL and 102 ± 3.63 µg/mL for α-amylase and 121.4 ± 1.88 and 56.6 ± 1.12 µg/mL for α-glucosidase, respectively, and the extracts lowered blood glucose levels in normal starch-loaded rats. Additionally, lipase inhibition was observed with aqueous (IC 50 = 25.3 ± 1.53 µg/mL) and ethanolic (IC 50 = 13.7 ± 3.03 µg/mL) extracts. Conclusion: These findings show the antioxidant, hypoglycemic, and hyperlipidemic effects of E. resinifera extracts, which should be investigated further to validate their medicinal uses and their pharmaceutical applications.
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