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Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs
Tian Guan,Jian Wang,Muqun Yang,Kai Zhu,Yong Wang,Guohui Nie 한국광학회 2016 Current Optics and Photonics Vol.20 No.2
This study has investigated the feasibility of 980-nm low-energy pulsed near-infrared laser stimulationto evoke auditory responses, as well as the effects of radiant exposure and pulse duration on auditoryresponses. In the experiments, a hole was drilled in the basal turn of the cochlea in guinea pigs. An opticalfiber with a 980-nm pulsed infrared laser was inserted into the hole, orientating the spiral ganglion cellsin the cochlea. To model deafness, the tympanic membrane was mechanically damaged. Acousticallyevoked compound action potentials (ACAPs) were recorded before and after deafness, and optically evokedcompound action potentials (OCAPs) were recorded after deafness. Similar spatial selectivity between opticaland acoustical stimulation was found. In addition, OCAP amplitudes increased with radiant exposure,indicating a photothermal mechanism induced by optical stimulation. Furthermore, at a fixed radiantexposure, OCAP amplitudes decreased as pulse duration increased, suggesting that optical stimulation mightbe governed by the time duration over which the energy is delivered. Thus, the current experiments havedemonstrated that a 980-nm pulsed near-infrared laser with low energy can evoke auditory neural responsessimilar to those evoked by acoustical stimulation. This approach could be used to develop optical cochlearimplants.