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      • KCI등재

        Thermo-mechanical analysis of soft tissue in local hyperthermia treatment

        Mohammad Mahdi Attar,Mohammad Haghpanahi,Hossein Shahverdi,Ali Imam 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.3

        Magnetic fluid hyperthermia is a new subclass of hyperthermia cancer treatment that can selectively heat up a tumor without damaging the surrounding healthy tissues. Some authors studied the temperature distribution of a magnetically mediated tumor assuming a homogeneous distribution of nanoparticles inside the tumor. Viscoelastic behavior of cancerous and healthy tissues have been studied in various articles and many methods have been introduced for computation of physical-mechanical properties of the tissue considering the fact that thermo-mechanical properties of the tissue completely change when the tissue becomes cancerous. Purpose of this study is to investigate thermo-visco-elastic behavior of tumorous and healthy bovine liver tissue. Therefore, the tumor is simulated as a solid sphere having radius denoted as r along with the surrounding healthy tissue. Any discontinuity between cancerous and healthy tissues is neglected. Since the resulting constitutive equations are highly complex, the stress and displacement fields were calculated by using finite difference method. An experimental test was designed to validate numerical results. Numerical results are found to be in good agreement with experimental data and with other references on homogeneous dispersion of nanoparticles.

      • KCI등재

        Analysis of bioheat transfer equation for hyperthermia cancer treatment

        Mohammad Mahdi Attar,Mohammad Haghpanahi,Saeid Amanpour,Mohammad Mohaqeq 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.2

        Magnetic fluid hyperthermia is a new subclass of hyperthermia cancer treatment that can selectively heat up a tumor without damagingthe surrounding healthy tissues. Some authors studied the temperature distribution of a magnetically mediated tumor assuming a homogeneousdistribution of nanoparticles inside the tumor. Practically speaking, the injected nanoparticles do not usually distribute uniformlythroughout the entire tumor, thus leaving some parts of the tumor without nanoparticles. In this study, an inhomogeneous dispersion ofnanoparticles inside the tumor is assumed to investigate the tissues’ temperature profiles. The problem is solved for polar coordinate. Also in this study, the heating effect of magnetic fluid in a porcine liver tissue is experimentally examined. Numerical transient solutionsare found to be in good agreement with experimental data.

      • KCI등재

        Large deformation modeling of flexible manipulators to determine allowable load

        Habib Esfandiar,Moharam H. Korayem,Mohammad Haghpanahi 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.5

        This paper focuses on the study of complete dynamic modeling and maximum dynamic load carrying capacity computation of N-flexible links and N-flexible joints mobile manipulator undergoing large deformation. Nonlinear dynamic analysis relies on the Timoshenko theory of beams. In order to model the system completely and precisely, structural and joint flexibility, nonlinear strain-displacement relationship, payload, and non-holonomic constraints will be considered to. A finite element solution method based on mixed method is applied to model the shear deformation. This procedure is considerably more involved than displacement based element and shear deformation can be readily included without inducing the shear locking in the element. Another goal of this paper is to present a computational procedure for determination of the maximum dynamic load of geometrically nonlinear manipulators with structural and joint flexibility. An effective measure named as Moment-Height Stability (MHS) measure is applied to consider the dynamic stability of a wheeled mobile manipulator. Simulations are performed for mobile base manipulator with two flexible links and joints. The results represent that dynamic stability constraint is sensitive when calculating the maximum carrying load. Furthermore, by changing the trajectory of end effector, allowable load also changes. The effect of torsional spring parameter on the joint deformation is investigated in a parametric sensitivity study. The findings show that, by the increase of torsional stiffness, the behavior of system approaches to a system with rigid joints and allowable load of robot is also enhanced. A comparison is also made between the results obtained from small and large deformation models. Fluctuation range in obtained figures for angular displacement of links and end effector path is bigger for large deformation model. Experimental results are also provided to validate the theoretical model and these have good agreement with the simulated results.

      • KCI등재

        Antibacterial properties of ferrimagnetic and superparamagnetic nanoparticles: a comparative study

        Mohammadhossein Shahsavari Alavijeh,Milad Salimi Bani,Iman Rad,Shadie Hatamie,Mahsa Soufi Zomorod,Mohammad Haghpanahi 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2

        In this study, antibacterial impact of magnetic nanocomposite (MNC: MoS2 /CoFe2O4) and super paramagnetic iron oxide nanoparticle (SPION: Fe3O4 -Casein) against staphylococcus aureus was studied. It was expected that such comparative study, address key points in optimization of synthesis and design of nanomaterials, which are supposed to be used as antibacterial agents for magnetic fluid hyperthermia (MFH) purposes. As the results, the MNC and SPION had average sizes of 17±4 nm and 15±5 nm, and diffused homogenously in agarose gel. They both were bacteriostatic against S. aureus at very low concentrations, while were bactericidal at concentrations of 200 µg/mL and more in MFH condition. In conclusion, both MNC and SPION inhibit S. aureus viability when low amplitude (H = 31.16 mT) alternative magnetic field (AMF: f = 150 kHz) was applied. Therefore, both of the nanomaterials are eligible to be considered as antibacterial candidates for treatment of complicated infections in upper respiratory tract or skin.

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