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Nonsrijun, Nongnuch,Mitchai, Jumphol,Brown, Kamoltip,Leksomboon, Ratana,Tuamsuk, Panya Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: The incidence of prostate cancer, one of the most common cancers in elderly men, is increasing annually in Thailand. Matrix metalloproteinase 11 (MMP-11) is a member of the extracellular matrix metalloproteases which has been associated with human tumor progression and clinical outcome. Aim: To quantify MMP-11 expression in prostatic adenocarcinoma tissues and to determine whether its overexpression correlates with survival outcome, and to assess its potential as a new prognostic marker. Materials and Methods: Expression of MMP-11 was analyzed using immunohistochemistry in 103 Thai patients with prostatic adenocarcinoma. Overall survival was analyzed using Kaplan-Meier methods and Cox regression models. Results: Immunoreactivity of MMP-11 was seen in the stroma of prostatic adenocarcinoma tissue samples, high expression being significantly correlated with poor differentiation in Gleason grading, pathologic tumor stage 4 (pT4), and positive-bone metastasis (p<0.05), but not age and prostatic-specific antigen (PSA) level. Patients with high levels of MMP-11 expression demonstrated significantly shorter survival (p<0.001) when compared to those with low levels. Multivariate analysis showed that MMP-11 expression and pT stage were related with survival in prostatic adenocarcinoma [hazard ratio (HR)=0.448, 95% confidence interval (95%CI)=0.212-0.946, HR=0.333, 95%CI=0.15-0.74, respectively]. Conclusions: Expression of MMP-11 is significantly associated with survival in prostatic adenocarcinoma. High levels may potentially be used for prediction of a poor prognosis.
Transmission Line Model for an Edge-Coupled Patch Antenna
Wiset Saksiri,Mitchai Chongcheawchamnan,Monai Krairiksh 한국전자통신연구원 2008 ETRI Journal Vol.30 No.5
In this paper, a simple transmission line model for an edge-coupled patch antenna is presented. The coupled section is modeled with a lump network which represents the mutual admittance between patches and from patch to ground. Theoretical analysis of two edge-coupled patch antenna models are compared by simulation and experiment in antennas designed to operate at the 2 GHz band. The proposed model predicts the return loss of the antenna accurately.