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Kwon, Misung,Lim, Su-Jin,Joung, Eun-Ji,Lee, Bonggi,Oh, Chul-Woong,Kim, Hyeung-Rak ELSEVIER SCIENCE B.V.; AMSTERDAM 2018 JOURNAL OF FUNCTIONAL FOODS Vol.47 No.-
<P><B>Abstract</B></P> <P> <I>Sargassum serratifolium</I> has diverse health-promoting effects because of high levels of meroterpenoids with strong antioxidant and anti-inflammatory activities. Here, we investigated the effects of a meroterpenoid-rich fraction of an ethanolic extract of <I>S. serratifolium</I> (MES) on obesity and obesity-related hepatic steatosis in high fat (HF)-fed C57BL/6J mice. MES supplementation markedly reduced HF diet-induced obesity and hepatic steatosis without changes in food intake. MES improved blood lipid profile and elevated circulating adiponectin. Furthermore, MES notably increased uncoupling protein 1 (UCP-1)-positive cells and decreased macrophage infiltration in adipose tissue. MES exerted the anti-obesity and lipid-lowering effects by activating AMPK-related fatty acid oxidation signaling and inhibiting SREBP1c-related lipogenesis signaling in liver and adipose tissues. Our study indicates that MES prevents diet-induced obesity and related metabolic disorders at least partially by activating energy expenditure signaling and inhibiting lipogenesis. MES may be used as a pharmaceutical agent against obesity and related metabolic syndrome.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MES include sargahydroquinoic acid, sargachromenol and sargaquinoic acid. </LI> <LI> Anti-obesity activity of MES is associated with lipogenesis and browning. </LI> <LI> MES could be a potential agent for the prevention of NAFLD and obesity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>