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Nam Minjeong,Yoon Sumi,Hur Mina,Lee Gun Hyuk,Kim Hanah,Park Mikyoung,Kim Hyeong Nyeon 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.4
Background: Digital morphology (DM) analyzers are increasingly being used for white blood cell (WBC) differentials. We assessed the laboratory efficiency of the Sysmex DI-60 system (DI-60; Sysmex, Kobe, Japan) in comparison with manual counting in leukopenic samples. Methods: In total, 40 peripheral blood smear samples were divided into normal, mild leukopenia, moderate leukopenia, and severe leukopenia groups based on WBC count. In each group, the risk and turnaround time (TAT) were compared between DI-60 and manual counting. Risk was determined by failure mode and effect analysis using the risk priority number (RPN) score, and TAT was recorded for the analytical phase. Results: Overall, DI-60 showed a five-fold lower risk (70 vs. 350 RPN) and longer TAT than manual counting. In severe leukopenic samples, DI-60 showed a shorter TAT/slide and a remarkably lower cell count/slide than manual counting. In all samples, the TAT/cell for DI-60 was substantially longer than that for manual counting (DI-60 vs. manual: total, 1.8 vs. 1.0 sec; normal, 1.5 vs. 0.7 sec; mild leukopenia, 1.9 vs. 0.9 sec; moderate leukopenia, 1.8 vs. 1.0 sec; severe leukopenia, 28.8 vs. 19.0 sec). Conclusions: This is the first comparative assessment of risk and TAT between DI-60 and manual counting in leukopenic samples. DI-60 decreases the laboratory risk and improves patient safety, but requires more time to count fewer cells, especially in severe leukopenic samples. DM analyzers should be applied selectively depending on the WBC count to optimize laboratory efficiency.
Anion Extraction-Induced Polymorph Control of Transition Metal Dichalcogenides
Nam, Dae-Hyun,Kim, Ji-Yong,Kang, Sungwoo,Joo, Wonhyo,Lee, Seung-Yong,Seo, Hongmin,Kim, Hyoung Gyun,Ahn, In-Kyoung,Lee, Gi-Baek,Choi, Minjeong,Cho, Eunsoo,Kim, Miyoung,Nam, Ki Tae,Han, Seungwu,Joo, You American Chemical Society 2019 NANO LETTERS Vol.19 No.12
<P>Controlled phase conversion in polymorphic transition metal dichalcogenides (TMDs) provides a new synthetic route for realizing tunable nanomaterials. Most conversion methods from the stable 2H to metastable 1T phase are limited to kinetically slow cation insertion into atomically thin layered TMDs for charge transfer from intercalated ions. Here, we report that anion extraction by the selective reaction between carbon monoxide (CO) and chalcogen atoms enables predictive and scalable TMD polymorph control. Sulfur vacancy, induced by anion extraction, is a key factor in molybdenum disulfide (MoS<SUB>2</SUB>) polymorph conversion without cation insertion. Thermodynamic MoS<SUB>2</SUB>-CO-CO<SUB>2</SUB> ternary phase diagram offers a processing window for efficient sulfur vacancy formation with precisely controlled MoS<SUB>2</SUB> structures from single layer to multilayer. To utilize our efficient phase conversion, we synthesize vertically stacked 1T-MoS<SUB>2</SUB> layers in carbon nanofibers, which exhibit highly efficient hydrogen evolution reaction catalytic activity. Anion extraction induces the polymorph conversion of tungsten disulfide (WS<SUB>2</SUB>) from 2H to 1T. This reveals that our method can be utilized as a general polymorph control platform. The versatility of the gas-solid reaction-based polymorphic control will enable the engineering of metastable phases in 2D TMDs for further applications.</P> [FIG OMISSION]</BR>
Minjeong Nam,Minjeong An 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim: This study aimed to examine the mediating effects of Efficacy Expectation for Eating Behavior (EEEB) and Outcome Expectation for Eating Behavior (OEEB) between depression and eating behavior among elderly patients with type 2 diabetes. Methods: A cross-sectional descriptive design was applied. The participants were 231 elderly patients aged 65 or older with type 2 diabetes in South Korea. Data were collected using a structured questionnaire including depression, EEEB, OEEB, and eating behavior. Data were analyzed using descriptive statistics, Pearson’s correlation coefficients. The mediating effects were analyzed using the SPSS PROCESS macro Version 3.4.1. Results: The average age was 77.52 years (SD= ±6.81, range= 18–71), and the sex distribution was 96 males and 135 females among 231 elderly patients with type 2 diabetes. Depression was significantly associated with eating behavior, EEEB and OEEB. EEEB and OEEB was significantly associated with eating behavior. EEEB and OEEB significantly mediated the association between depression and eating behavior among elderly patients with type 2 diabetes. Conclusions: The findings suggest that strategies for enhancing EEEB and OEEB should be considered to improve eating behavior of elderly patients with type 2 diabetes. Also, medical workers should consider EEEB and OEEB in providing education or consultation related to nutrition for elderly type 2 diabetes patients with depressive symptoms.
Nam Minjeong,Song Eun Young 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.4
Since the introduction of the Luminex technique to detect donor-specific antibodies (DSAs) in kidney transplantation, efforts have been made to determine the risk of pre-operative low-level DSAs. The risk of low-level DSAs can be stratified by the mean fluorescence intensity (MFI), based on the highest level or sum [1]. However, the relative amount of antigen expressed on Luminex beads for each HLA locus varies from that expressed in vivo [2]. Therefore, caution is needed when applying the same MFI criteria to each HLA locus. Accordingly, the flow cytometric crossmatch test, which detects the actual binding of a DSA to donor lymphocytes, remains an important pre-transplantation test despite recognized limitations such as inter-laboratory and person-to-person variations or false positives due to non-HLA antibodies [3]. Therefore, it is meaningful to analyze the clinical impact of pre-operative low-level DSAs determined by a positive Luminex result but negative flow cytometric crossmatch (PLNF) on kidney transplantation outcomes.
( Minjeong Kim ),( Ji Seong Jeong ),( Hyunji Kim ),( Seungwoo Hwang ),( Il-hyun Park ),( Byung-chul Lee ),( Sung Il Yoon ),( Sun Ha Jee ),( Ki Taek Nam ),( Kyung-min Lim ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5
Phthalates widely used in the manufacture of plastics have deeply penetrated into our everyday lives. Recently, a concern over the toxicity of phthalates on thyroid, has been raised but in most of cases, the doses employed were unrealistically high. To investigate the effects of phthalates on thyroid, we investigated the effects of the repeated oral exposure to low to high doses (0.3, 3, 30 and 150 mg/kg) di-2-ethylhexylphthalate (DEHP) from weaning to maturity for 90 days in juvenile rats on the thyroid. The histological examination revealed that DEHP significantly induced hyperplasia in the thyroid from the doses of 30 mg/kg, which was confirmed with Ki67 staining. In line with this finding, increased mRNA expression of thyrotropin releasing hormone (Trh) was observed in the thyroid of female at 0.3 mg/kg and 150 mg/kg as determined by RNAseq analysis. Moreover, significantly increased expression of parathyroid hormone (Pth) in the female at 0.3 mg/kg, and thyroglobulin (Tg) and thyroid hormone responsive (Thrsp) in the male at 0.3 mg/kg were noted in the blood, of which changes were substantially attenuated at 150 m/kg, alluding the meaningful effects of low dose DEHP on the thyroid hormone regulation. Urinary excretion of mono-2-ethylhexyl-phthalate (MEHP), a major metabolite of DEHP was determined to be 4.10 and 12.26 ppb in male, 6.65 and 324 ppb in female at 0.3 and 30 mg/kg DEHP, respectively, which fell within reported human urine levels. Collectively, these results suggest a potential adverse effects of low dose phthalates on the thyroid.
( Minjeong Kim ),( Jun-won Yun ),( Kyeho Shin ),( Yejin Cho ),( Mijeong Yang ),( Ki Taek Nam ),( Kyung-min Lim ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.2
Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts for >50% of reported DILI cases but little is known for the cause of individual variations in the severity. Intrinsic genetic variation is considered a key element but the identity of the genes was not well-established. Here, pre-biopsy method and microarray technique was applied to uncover the key genes for APAP-induced liver injury in mice, and a cause and effect experiment employing quantitative real-time PCR was conducted to confirm the correlation between the uncovered genes and APAP-induced hepatotoxicity. We identified the innately and differentially expressed genes of mice susceptible to APAP-induced hepatotoxicity in the pre-biopsied liver tissue before APAP treatment through microarray analysis of the global gene expression profiles (Affymetrix GeneChip<sup>®</sup> Mouse Gene 1.0 ST for 28,853 genes). Expression of 16 genes including Gdap10, Lpl, Gabra3 and Ccrn4l were significantly different (t-test: FDR <10%) more than 1.5 fold in the susceptible animals than resistant. To confirm the association with the susceptibility to APAP-induced hepatotoxicity, another set of animals were measured for the expression level of selected 4 genes (higher two and lower two genes) in the liver pre-biopsy and their sensitivity to APAP-induced hepatotoxicity was evaluated by post hoc. Notably, the expressions of Gabra3 and Lpl were significantly correlated with the severity of liver injury (p<0.05) demonstrating that these genes may be linked to the susceptibility to APAP-induced hepatotoxicity.