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RISS 인기검색어
- 검색키워드
- 저자 : Middha Sushil Kumar (검색결과 3 건)
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Baccaurea ramiflora Lour.: a comprehensive review from traditional usage to pharmacological evidence
Arvind Kumar Goyal,Middha Sushil Kumar,Talambedu Usha 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2
Baccaurea ramiflora Lour. syn. Baccaurea sapida (Roxb.) Muell. Arg. widely known as Burmese grape is native to Southeast Asia. Its leaves, fruits, stem, bark, seeds forms an ingredient in many herbal prescriptions which have been used to treat jaundice, constipation, indigestion, cellulitis, as antidote for sanke venome, antiphlogistic and anodyne against rheumatoid arthritis etc. In the recent years, this plant has been largely explored on scientific grounds to identify the chemical constituents and pharmacological activities. The present review work is an effort to revisit the scientific works done to evaluate the scope for bioprospection of B. ramiflora. Based on the study designed, a number of research papers were reviewed, but only about 35 articles having information on B. ramiflora were evaluated in detail. In total, thirty compounds have been isolated and characterised so far from different parts of this evergreen tree, which accounts for its myriad medicinal value including analgesic, anthelmintic, antioxidant, anti-diarrheal, anti-inflammatory, cytotoxic, haemolytic, hypoglycemic, hypolipidemic, insecticidal, neuropharmacological, thrombocytic, anti-fungal and antimicrobial activities. This compilation of assorted information underpins the basic perceptive of B. ramiflora and opens up new horizon for further phytochemical evaluation, safety efficacy, and clinical trials.
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Usha, Talambedu,Goyal, Arvind Kumar,Lubna, Syed,Prashanth, H.P.,Mohan, T. Madhan,Pande, Veena,Middha, Sushil Kumar Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: Punica granatum (family: Lythraceae) is mainly found in Iran, which is considered to be its primary centre of origin. Studies on pomegranate peel have revealed antioxidant, anti-inflammatory, anti-angiogenesis activities, with prevention of premature aging and reducing inflammation. In addition to this it is also useful in treating various diseases like diabetes, maintaining blood pressure and treatment of neoplasms such as prostate and breast cancer. Objectives: In this study we identified anti-cancer targets of active compounds like corilagin (tannins), quercetin (flavonoids) and pseudopelletierine (alkaloids) present in pomegranate peel by employing dual reverse screening and binding analysis. Materials and Methods: The potent targets of the pomegranate peel were annotated by the PharmMapper and ReverseScreen 3D, then compared with targets identified from different Bioassay databases (NPACT and HIT's). Docking was then further employed using AutoDock pyrx and validated through discovery studio for studying molecular interactions. Results: A number of potent anti-cancerous targets were attained from the PharmMapper server according to their fit score and from ReverseScreen 3D server according to decreasing 3D scores. Conclusion: The identified targets now need to be further validated through in vitro and in vivo studies.
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The therapeutic potential and the health benefits of Morus indica Linn.: a mini review
Boro Hankhray,Das Sandeep,Middha Sushil Kumar 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.2
Morus indica (L.) commonly known as Indian mulberry belonging to the family Moraceae is a fast growing perennial plant and is the primary food plant for the monophagous insect Bombyx mori has a special significance in the sericulture industry. Medicinal properties of this plant have been depicted in the ancient literature of Ayurveda. Some of the ayurvedic preparations use fruits, leaves, roots, bark or latex of the mulberry plant as potential treatment aid against various diseases. Because of the presence of several bioactive compounds like steroids, phenolics, alkaloids, reducing sugars, tannins, fla-vonoids, anthocyanins, terpenoids, cardiac glycosides, saponins, proteins, amino acids, carbohydrates etc., it is traditional being used as natural medicine for- anti-bacterial, anti-fugal, anti-hyperglycaemic, anti-hypoglycaemic, anti-hypolipidemic, hepatoprotective, anti-diabetic, anti-cancer, anti-pyretic, high antioxidant, and anti-inflammatory properties. The present review reveals the wide range of important uses of Indian mulberry including its phytochemical composition, antioxidants and medicinal properties and management towards human diseases.
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