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Stability of Albuterol in Continuous Nebulization
Hunter, Dee A.,Fox, Janet L.,Yoo, Sun D.,Michniak, Bozena B. 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Due to the emergent nature of situations requiring continuous nebulization of albuterol, a premixed albuterol solution would provide faster access to the therapy when required. The purpose of this study was to evaluate the stability of albuterol solutions at a concentration (200㎍/mL) used in continuous nebulization when stored in various containers of polyvinyl chloride bags, polyolefin bags, polypropylene syringes and tubes and borosilicate glass tubes. Solutions were prepared in triplicate in 0.9% sodium chloride stored under refrigerated and room temperatures for seven days. Samples were removed and analyzed using a stability-indicating high-performance Liquid chromatography assay method. Albuterol was found to be stable (>90% of the initial concentration remaining) for at least seven days in all five types of containers under the conditions tested.