한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

N-Arylnortropinone 유도체의 합성연구

李龍均,朴유미,鄭大一,金寅植,朴鍾勳,盧信愛,鄭逸守,朴敏洙 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1

Tropinone 화합물들은 색다른 고리계의 존재로 아주 오래전부터 약리학적으로 매우 흥미로운 연구과제로 주목되어 최근에 그들의 합성법,?? 입체적 구조분석?? 그리고 약리학적인 연구??가 활발히 진행되고 있다. Tropinone 1은 흔히 마약으로 알려져 있는 cocaine 2, 소염작용과 항경련성 작용 및 심장박동수를 조절 등 다양한 약리작용을 하는 tropane spirohy-dantoin ?? 그리고 안과질환을 검사 할 때 눈의 동공을 확장시키는 데 사용하는 atropine ??등을 합성하는 데 중요한 중간체이다. ??????????? Trigo, G, G등 ??은 aliphatic amine과 succinic aldehyde를 acetonedicarboxylic acid와 반응하여 nortropane 유도체를 합성하였으며, 그 후 [3+2] nitrone cycloaddition? 과 [3+4] cyclocoupling? 을 거치는 tropane alkaloid의 새로운 합성법이 개발되었다. 최근 lzquier M. L. 등¹은 acetonedicarboxylic acid를 사용하여 1차 지방족 amine과 succinic aldehyde대신 2,5-dimethoxytetrahydrofuran을 반응시켜 N-alkyl nortropinone 유도체를 합성하였다. 그러나 일반적으로 빙초산 속에서 amine과 2,5-dimethoxytetrahydrofuran을 반응시키면 pyrrole 유도체가 합성되어진다.?? 이러한 사실은 분명히 반응조건(예, 산, 온도)에 따른 다양한 화학이 존재한다고 볼 수 있다. 따라서 우리는 반응조건, 즉 산의 변화 및 온도 변화에 의한 amine과 2,5-dimethoxytetrahydrofuran의 반응을 자세하게 검토하면서 새로운 N-arylnortropinone 유도체를 합성하고자 한다.

코눈물관막힘 환자에서 폴리우레탄 스텐트 삽입술의 장기적 경과

노인호,최미영,차상훈,배일헌 충북대학교 의과대학 충북대학교 의학연구소 2005 忠北醫大學術誌 Vol.15 No.1

Purpose: To assess the long-term results of the nasolacrimal polyurethane stent placement in nasolacrimal obstruction. Subject and Methods: Fluoroscopically guided placement of a polyurethane nasolacrimal stent in Song nasolacrimal stent set was performed in nasolacrimal obstruction. Follow-up was at least 6 months. The success was defined that there was no lacrimal symptoms with lacrimal passage to irrigation at the final visit. Additionally, the symptoms of between the initial and the recurred obstruction were compared. Results: Of the 42 cases in 38 patients, stent placement was technically successful in 38 cases of 34 patients. The analysis was performed in 22 cases of 19 patients because 15 patients had to be excluded due to short follow-up duration. At the final examination, the stent placement was successful in 6 of 22 cases. The mean follow-up duration was significantly longer in the failed group than in the succeeded group (13 months: 50 months, p = 0.000). There was pustile discharge in one of 22 case at initial, while there was discharge in all cases at recurred symptoms, especially pustile or bloody in 6 of 16 cases. Conclusion: The long-term results achieved using polyurethane nasolacrimal stent were not encouraging. The careful follow-up and proper management are necessary to prevent complicated dacryocystitis. 연구목적: 코눈물관막힘 환자에서 폴리우레탄 스텐트 삽입술의 장기적 효과에 대하여 알아보고자 하였다. 대상 및 방법: 코눈물관막힘 환자에서 투시기의 안내 하에 Song 코눈물관 스텐트 세트를 이용하여 폴리우레탄 스텐트를 삽입한 후, 최소한 6개월 이상 관찰한 경우를 대상으로 하였다. 최종 내원 시 증상 및 코눈물관세척의 결과에 따라 성공여부를 결정하였으며, 초진 시와 재발 시의 증상을 비교하였다. 결과: 38명 42예 중 34명 38예에서 폴리우레탄 스텐트의 삽입에 성공하였다. 이 중 관찰기간이 6개월 미만인 경우를 제외하고, 19명 22예에 대하여 분석하였다. 최종 내원 시 성공군은 22예 중 6예이었으며, 성공군에 비하여 실패군의 시술 후 관찰기간이 통계학적으로 유의하게 길었다(13개월: 50개월, p=0.000). 초진 시 고름이 섞인 눈곱이 있었던 경우가 1예이었던 것에 비하여, 재발 시에는 16예 모두에서 눈곱이 있었으며, 이 중 6예에서는 고름이나 피가 섞여 있었다. 결론: 코눈물관막힘 환자에서 폴리우레탄 스텐트 삽입술의 장기적 예후는 부량하였으며, 이차적으로 눈물주머니염이 발생하는 것을 예방하기 위하여 주의 깊은 관찰과 적절한 치료가 필요할 것으로 생각한다.

Expression of the structural proteins of porcine reproductive and respiratory syndrome virus in Bm5 cells

Jeong Mi Oh,Jae Kyung Lee,Hyun Na Koo,Jae Young Choi,Kwang Sik Lee,Jong Yul Roh,Yeon Ho Je,Byung Rae Jin,Sung Sik Yoo,Jae Su Kim,Young In Kim,In Joon Yoon,Soo Dong Woo 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10

The porcine reproductive and respiratory syndrome virus (PRRSV) has six structural proteins which encoded by ORFs 2 to 7 are designated as GP2, 3, 4, 5, M and N, repectively. In this study, we determined the expression of each protein using novel transfer vector, pBmKSK4 which has the polyhedrin promoter of BmNPV and 6xHis tag. The recombinant transfer vector was co-transfected into Bm5 cells along with bBpGOZA DNA. Recombinant virus was purified by plaque assay and amplified in Bm5 cells. Expression of each protein was identified by SDS-PAGE and Western blot analysis using anti-6xHis monoclonal antibody. The expression levels of the structural proteins in Bm5 cells were stronger than the expression system using pBacPAK9 transfer vector in Sf21 cells. As expected, GP5 was expressed at low levels from its structural properties and its toxicity for cells. In addition, each recombinant protein was purified using Ni-NTA spin columns. The ability to produce each protein in the baculovirus system indicates that these could be major candidates for the development of a vaccine against PRRSV.

거짓내사시의 경력이 있는 사시 환자의 임상 양상

노인호,최미영,In Ho Roh,Mi Young Choi 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: The epicanthal fold in Korean children is a common cause of pseudoesotropia. Therefore, the present study was undertaken to evaluate the clinical characteristics of strabismus in children diagnosed with pseudoesotropia. Methods: We reviewed the charts of children diagnosed with strabismus from February 2004 to January 2005. Strabismic children with a history of pseudoesotropia were included in this study. We recorded the age and chief complaints at the time of pseudoesotropia diagnosis as well as the type of strabismus, the visual acuity, chief complaints, and refractive error at the time of strabismus diagnosis. Results: One hundred and two of 734 children with strabismus (13.9%) had a history of pseudoesotropia. The mean age at the time of pseudoesotropia diagnosis was 2.9 years. The mean age at the time of strabismus diagnosis was 4.4 years. The type of strabismus was exotropia in 58 (56.9%) and esotropia in 39 (38.2%) cases. Refractive accommodative esotropia was seen in 89.7% of esotropia cases and the basic type was seen in 86.2% of exotropia cases. The concurrence rate between chief complaints of pseudoesotropia and the type of strabismus diagnosed was lower in exotropia than in esotropia. There was hyperopia in all the esotropia cases, and the distribution of refractive error was variable in exotropia. The frequency of amblyopia was 19.6%. Conclusions: The incidence of strabismus is high in the case of children diagnosed with pseodoesotropia. Therefore, regular examinations for strabismus, refractive error and amblyopia may be necessary.

FCT 1-5 Ingenol mebutate in the treatment of melanoma

( Jimyung Seo ),( Young In Lee ),( Kyoung Ae Nam ),( Jihee Kim ),( Jun Young Kim ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Noninvasive, tissue-sparing, topical treatments may be a highly desirable option in the treatment of melanoma. A number of topical drugs are used off-label or are under investigation. Objectives: We report our treatment experience with ingenol mebutate in patients with melanoma, and evaluate the efficacy and safety of this treatment as a monotherapy or neoadjuvant treatment. Methods: This is a retrospective study on patients with melanomas who underwent topical treatment with ingenol mebutate. Results: A total of five patients (five female; median age, 67 years; age range, 44.87 years) were identified from our search. Considering the anatomically challenging locations and the morbidity of surgery, ingenol mebutate was administered as a monotherapy in two patients with melanoma in situ. The remaining three patients were treated with topical ingenol mebutate before surgery. Of the five patients, only one patient, who had melanoma in situ on the vaginal mucosa and underwent slow Mohs micrographic surgery, presented local recurrence during the follow-up period (13.8 ± 2.8 months). Conclusion: Despite limitations arising from the small number of patients analyzed and the retrospective design, the results of this study provide additional insights into the role of ingenol mebutate in the treatment of in situ melanoma or melanoma on an anatomically challenging location. Further studies are needed to establish the prerequisites that can ensure treatment success.

Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea

Lee, Doo Ri,Lee, Chang Hyu,Won, Youn Kyung,Suh, Dong In,Roh, Eui-Jung,Lee, Mi-Hee,Chung, Eun Hee The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.10

Purpose: Croup is a common pediatric respiratory illness with symptoms of varying severity. Moreover, epiglottitis is a rare disease that can rapidly progress to life-threatening airway obstruction. Although the clinical course and treatments differ between croup and epiglottitis, they are difficult to differentiate on presentation. We aimed to compare the clinical characteristics of croup and epiglottitis in Emergency Department patients. Methods: The 2012 National Emergency Department Information System database of 146 Korean Emergency Departments was used to investigate patients aged ${\leq}18years$ presenting with croup or epiglottitis. Results: We analyzed 19,374 croup patients and 236 epiglottitis patients. The male:female sex ratios were 1.9:1 and 2.3:1 and mean ages were $2.2{\pm}2.0$ and $5.6{\pm}5.8years$, respectively. The peak incidence of croup was observed in July and that of epiglottitis was observed in May. The hospitalization rate was lower in croup than in epiglottitis patients, and the proportion of patients treated in the intensive care unit was lower among croup patients. The 3 most common chief complaints in both croup and epiglottitis patients were cough, fever, and dyspnea. Epiglottitis patients experienced dyspnea, sore throat, and vomiting more often than croup patients (P<0.05). Conclusion: Both groups had similar sex ratios, arrival times, 3 most common chief complaints, and 5 most common comorbidities. Epiglottitis patients had a lower incidence rate, higher mean age of onset, and higher hospitalization rate and experienced dyspnea, sore throat, and vomiting more often than croup patients. Our results may help in the differential diagnosis of croup and epiglottitis.

Yield and Quality Responses of Greenhouse Tomato Fruits to Potassium Application Amount in Fertigation Culture

Mi Young Roh,In Ho Yu,Myeong Whan Cho,Nam Jun Kang,Han Cheol Rhee,Tae Cheol Seo,Gyeong Lee Choi 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-

Cloning and Functional Expression of the ddh Gene Involved in the Novel Pathway of Lysine Biosynthesis frpm Brevibacterium lactofermentum

Roh, Jung hyeob,Kim, Ok Mi,Park, Dong Chul,Kim, Hyun Jeong,Yun, Hyon Kyung,Kim, Sang Dal,Lee, In-Seon,Lee, Kap Rang Korean Society of Molecular Biology 1994 Molecules and cells Vol.4 No.3