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Md. Rakibul Hassan Bulbul,Md. Atiar Rahman,Md. Zillur Rahman,Talha Bin Emran,Mirola Afroze,Mala Khan,Muhammad Abid Hasan Chowdhury,Mohammed Auwal Ibrahim,Mohammed Sohel Chowdhury 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.1
This study investigated the restorative effect of Leea macrophylla ethanol root extract (LMERE) in carbon tetrachloride (CCl4) induced hepatic injury. It also tried to unfold the underlying mechanism through ligand-receptor interactions. Prior to conduct the CCl4 induced animal model study, the in vitro antioxidative capacities of LMERE were investigated. Gas chromatography mass spectroscopy (GC–MS) was accomplished to identify the prevalent bioactive compounds. The molecular docking was performed using Schrödinger Suites 2017-1. Results showed the promising antioxidative potentials of LMERE in in vitro models. Upon treatment of CCl4 intoxicated animals with LMERE, serum ALT and AST were found to be significantly (p < 0.05) reduced compared to the CCl4 control while LMERE50 was noted as the best dose in restoring the hepatic markers. Serum lipids and total protein were significantly restored compared to control. Remarkable changes of cell necrosis, apoptosis and sinusoidal dilution were noticed in histopathological assay of liver tissue. mRNA expression for superoxide dismutase (SOD1) and catalase was multifold increased which are statistically significant compared to reference drug, silymarin. In docking study, octadecanoic acid showed the lowest binding energy and highest binding affinity with the protein (ID: 1VKX) which is a crystallized structure of NF-κB p50/p65 heterodimer involved in cytokine production. The findings demonstrate that LMERE restores the hepatic damage by the mRNA expression of antioxidative enzymes while LMERE50, at a glance, seems the most suitable dose.
Update on the Effects of Sound Wave on Plants
Md. Emran Khan Chowdhury,배한홍,임현섭 한국식물병리학회 2014 식물병연구 Vol.20 No.1
Plant growth is considered the sum of cell proliferation and subsequent elongation of the cells. The continuousproliferation and elongation of plant cells are vital to the production of new organs, which have a significantimpact on overall plant growth. Accordingly, the relationship between environmental stimuli, such as temperature,light, wind, and sound waves to plant growth is of great interest in studies of plant development. Sound waves can have negative or positive effects on plant growth. In this review paper we have summarizedthe relationship between sound waves and plant growth response. Sound waves with specific frequenciesand intensities can have positive effects on various plant biological indices including seed germination, rootelongation, plant height, callus growth, cell cycling, signaling transduction systems, enzymatic and hormonalactivities, and gene expression.
Update on the Effects of Sound Wave on Plants
Chowdhury, Md. Emran Khan,Lim, Hyoun-Sub,Bae, Hanhong The Korean Society of Plant Pathology 2014 식물병연구 Vol.20 No.1
Plant growth is considered the sum of cell proliferation and subsequent elongation of the cells. The continuous proliferation and elongation of plant cells are vital to the production of new organs, which have a significant impact on overall plant growth. Accordingly, the relationship between environmental stimuli, such as temperature, light, wind, and sound waves to plant growth is of great interest in studies of plant development. Sound waves can have negative or positive effects on plant growth. In this review paper we have summarized the relationship between sound waves and plant growth response. Sound waves with specific frequencies and intensities can have positive effects on various plant biological indices including seed germination, root elongation, plant height, callus growth, cell cycling, signaling transduction systems, enzymatic and hormonal activities, and gene expression.