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Md. Ahsanur Reza,Joong-su Lee,Seung-jin Lee,Woo-Sik Jo,Seung-chun Park 한국버섯학회 2011 버섯 Vol.15 No.2
The aim of this study was to investigate the suppressive activity of 70% ethanol extract and its dichloromethane fraction from Auricularia auricula-judae against adipogenesis and lipogenesis in 3T3-L1 preadipocytes. The ethanol extract and its dichloromethane fraction suppressed the differentiation and decreased lipid droplets in vitro. The dose-dependent increasing concentration of glycerol and lower triglycerides accumulation were found significantly (P < 0.05) with the treatment of both fractions from 70% ethanolic Auricularia auricula-judae extract and the glycerol-3-3phosphate dehydrogenase (GPDH) activity was also inhibited by both extracts. Further, the expression of adipogenic mRNAs were investigated by RT-PCR amplification. The key transcriptional factors, PPARγ and C/EBPα were decreased significantly at dose-dependent manner by both extracts of Auricularia auricula-judae. The expressions of LPL and FAS were also decreased by presence of these extracts. The decreased expressions of C/EBPβ, C/EBPγ and ACC1 were observed only by ethanol extract at 300 μg/ml concentration, while the expression of SREBP-1c, GLUT4 and aP2 were not altered in the 3T3-L1 adipocytes. These changes were occurred without the cytotoxic effect of both extracts against 3T3-L1 adipocytes in vitro. A positive control, fenofibrate inhibited the differentiation, triglycerides accumulation through PPARγ signaling by 2/3 reduction of PPARγ expression. Thus, these findings suggest that both extracts of Auricularia auricula-judae might be used to inhibit the differentiation of 3T3-L1 preadipocytes and reduction of triglycerides accumulation.
Reza, Md.Ahsanur,Hossain, Md. Akil,Lee, Seung-Jin,Yohannes, Sileshi Belew,Damte, Dereje,Rhee, Man-hee,Jo, Woo-Sik,Suh, Joo-Won,Park, Seung-Chun Begell House Inc. 2014 INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS Vol.16 No.1
<P>In this study, a dichloromethane fraction (DCMF) from 70% Auricularia auricula-judae ethanol extract showed the highest level of antitumor activity compared to other solvent fractions (ethyl acetate, butanol, and water). The DCMF was found to have more potent antitumor activity against broncheoalveolar cancer (half maximal inhibitory concentration = 57.2 ?g/mL) and gastric cancer cells (half maximal inhibitory concentration = 73.2 ?g/mL) compared to the other solvent fractions, although all fractions inhibited the proliferation of the tumor cells in a dose-dependent manner. We further analyzed the DCMF composition by gas chromatography-coupled mass spectroscopy. Based on the results of this analysis, an antitumor active component (diazane) was identified in the DCMF. However, we found that diazane alone had a lower level of antitumor activity than the DCMF. These findings indicate that other unknown components of the DCMF also are responsible for the cytotoxic effects of DCMF against tumor cells. Semiquantitative reverse transcription polymerase chain reaction analysis demonstrated that DCMF induced cytotoxicity or tumor cell apoptosis as a result of the downregulation of Bcl-2 expression and p53 overexpression. Taken together, our study results demonstrated that the DCMF may be used as a functional additive for enhancing antioxidant activities and suppressing tumor growth in the body.</P>
Damte, Dereje,Reza, Md. Ahsanur,Lee, Seung-Jin,Jo, Woo-Sik,Park, Seung-Chun Korean Society of ToxicologyKorea Environmental Mu 2011 Toxicological Research Vol.28 No.1
The present study investigated the anti-inflammatory effects of dichloromethane extract of Auricularia auricula-judae. Dichloromethane extract of Auricularia auricula-judae inhibited Lipopolysaccharide (LPS)-induced nitric oxide (NO) production significantly in a dose-dependent manner in the concentration ${\geq}\;10\;{\mu}g/ml$ (p < 0.05). Furthermore, RT-PCR results of this study indicated that the extract markedly reduced the expressions of inflammatory cytokines (IL-6, TNF-$\alpha$ and IL-$1{\beta}$) mRNA in LPS-treated murine RAW 264.7 macrophages, which could possibly ameliorate the inflammation. Nevertheless, dichloromethane extract of Auricularia auricula-judae did not show complete inhibition of IL-6 mRNA expression. The inhibition of IL-$1{\beta}$ cytokine at protein level was also observed in a dose dependent manner. In conclusion, the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-$\alpha$ and IL-$1{\beta}$ in LPS-stimulated macrophages.
Dereje Damte,Md. Ahsanur Reza,Seung-Jin Lee,Woo-Sik Jo,Seung-Chun Park 한국독성학회 2011 Toxicological Research Vol.27 No.1
The present study investigated the anti-inflammatory effects of dichloromethane extract of Auricularia auricula-judae. Dichloromethane extract of Auricularia auricula-judae inhibited Lipopolysaccharide (LPS)-induced nitric oxide (NO) production significantly in a dose-dependent manner in the concentration ≥ 10 μg/ml (p < 0.05). Furthermore, RT-PCR results of this study indicated that the extract markedly reduced the expressions of inflammatory cytokines (IL-6, TNF-α and IL-1β) mRNA in LPS-treated murine RAW 264.7 macrophages, which could possibly ameliorate the inflammation. Nevertheless, dichloromethane extract of Auricularia auricula-judae did not show complete inhibition of IL-6 mRNA expression. The inhibition of IL-1β cytokine at protein level was also observed in a dose dependent manner. In conclusion, the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-α and IL-1β in LPS-stimulated macrophages.
Studies on Dermal and Ocular Irritation of Prodigiosin Isolated from Zooshikella rubidus
김용숙,최종명,윤정훈,최명진,Md. Ahsanur Reza,박승춘 한국독성학회 2009 Toxicological Research Vol.25 No.4
This study was carried out to investigate the irritation of the prodigiosin isolated from Zooshikellarubidus on the skin and eyes in New Zealand white rabbits. The tests were performed on the basisof Korea Food and Drug Administration (KFDA) guidelines. Prodigiosin induced severe eye irritationat high concentration (0.5 g/site/ml) but there was no eye irritation at low concentration (0.3 mg/site/ml). The primary irritation index was calculated from higher concentration (0.5 g/site/ml) to lower concentration(0.3 mg/site/ml). There were found non-irritation or induced mild irritation at lower concentrationof prodigiosin application. On the basis of this study, it could be concluded that theprodigiosin may be non-irritant to mild irritant of usual application at lower concentration (0.3 mg/site)resulting it is safe and useful in dyeing technology of fabrics.
Studies on the Dermal and Ocular Irritation of Prodigiosin Isolated from Zooshikella rubidus
Yong-Sook Kim,Jong-Myoung Choi,Jung-Hoon Yoon,Myung-Jin Choi,Md. Ahsanur Reza,Seung-Chun Park 한국독성학회 2009 Toxicological Research Vol.25 No.4
This study was carried out to investigate the irritation of the prodigiosin isolated from Zooshikella rubidus on the skin and eyes in New Zealand white rabbits. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. Prodigiosin induced severe eye irritation at high concentration (0.5 g/site/㎖) but there was no eye irritation at low concentration (0.3 ㎎/site/㎖). The primary irritation index was calculated from higher concentration (0.5 g/site/㎖) to lower concentration (0.3 ㎎/site/㎖). There were found non-irritation or induced mild irritation at lower concentration of prodigiosin application. On the basis of this study, it could be concluded that the prodigiosin may be non-irritant to mild irritant of usual application at lower concentration (0.3 ㎎/site) resulting it is safe and useful in dyeing technology of fabrics.
Studies on the Dermal and Ocular Irritation of Prodigiosin Isolated from Zooshikella rubidus
Kim, Yong-Sook,Choi, Jong-Myoung,Yoon, Jung-Hoon,Choi, Myung-Jin,Reza, Md. Ahsanur,Park, Seung-Chun Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.4
This study was carried out to investigate the irritation of the prodigiosin isolated from Zooshikella rubidus on the skin and eyes in New Zealand white rabbits. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. Prodigiosin induced severe eye irritation at high concentration (0.5 g/site/ml) but there was no eye irritation at low concentration (0.3 mg/sitel ml). The primary irritation index was calculated from higher concentration (0.5 g/site/ml) to lower concentration (0.3 mg/site/ml). There were found non-irritation or induced mild irritation at lower concentration of prodigiosin application. On the basis of this study, it could be concluded that the prodigiosin may be non-irritant to mild irritant of usual application at lower concentration (0.3 mg/site) resulting it is safe and useful in dyeing technology of fabrics.