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- 저자 : McCrudden, Maelí (검색결과 2 건)
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Microneedle-Mediated Transdermal Delivery of Bevacizumab
Courtenay, Aaron J.,McCrudden, Maelí,osa T. C.,McAvoy, Kathryn J.,McCarthy, Helen O.,Donnelly, Ryan F. American Chemical Society 2018 Molecular pharmaceutics Vol.15 No.8
<P>Bevacizumab is a recombinant humanized monoclonal antibody used clinically as a combination chemotherapeutic. Antibody therapeutics are usually formulated as parenteral injections, owing to their low oral bioavailability. Microneedle technology provides a transdermal alternative for drug-delivery using micron-scale needle structures to penetrate directly through the <I>stratum corneum</I> into the dermal interstitium. This study describes the design, formulation, and <I>in vitro</I> characterization of both dissolving and hydrogel-forming microneedle array platforms for transdermal delivery of bevacizumab. Bevacizumab recovery and transdermal permeation studies were conducted and analyzed using bevacizumab specific ELISA. Prototype microneedle-patches were tested <I>in vivo</I> in Sprague-Dawley rats with serum, exterior lumbar and axial lymph nodes, spleen, and skin tissue concentrations of bevacizumab reported. This work represents the first example of high dose transdermal delivery of an antibody therapeutic <I>in vivo</I> using dissolving and hydrogel-forming microneedle platforms. Basic pharmacokinetic parameters are described including hydrogel-forming microneedles: <I>C</I><SUB>max</SUB> 358.2 ± 100.4 ng/mL, <I>T</I><SUB>max</SUB> 48 h, AUC 44357 ± 4540, and <I>C</I><SUB>ss</SUB> 942 ± 95 ng/mL, highlighting the potential for these devices to provide sustained delivery of antibody therapeutics to the lymph and systemic circulation. Targeted delivery of chemotherapeutic agents to the lymphatic system by MN technology may provide new treatment options for cancer metastases.</P> [FIG OMISSION]</BR>
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The Effects of Informational Complexity and Working Memory on Problem-Solving Efficiency
Bobby Hoffman,Matthew T. McCrudden,Gregory Schraw,Kendall Hartley 서울대학교 교육연구소 2008 Asia Pacific Education Review Vol.9 No.4
This study investigated the influence of informational complexity and working memory capacity oil problem-solving efficiency, We examined two predictions of the situational efficiency hypothesis, which states efficiency of problem solving varies as a function of situational constraints. One prediction is that informational complexity affects problem-solving efficiency. A second prediction is that working memory capacity affects problem-solving efficiency. Students completed a working memory task and solved abstract and concrete syllogisms. Participants solved abstract syllogisms more accurately than concrete syllogisms and spent more time solving abstract syllogisms. Thus participants demonstrated greater problem-solving efficiency when solving concrete syllogisms. Results indicate that there is a trade-off between problem-solving accuracy and problem-solving time when information differs with respect to informational complexity, a phenomenon we refer to as the efficiency paradox. Working memory capacity did not affect accuracy or efficiency. The results support the conclusion that problem-solving efficiency is situational and a function of the complexity of information. Educational implications and directions for future research are suggested.
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