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Protective effects of polyphenols against endocrine disrupting chemicals
Matthew P. Madore,Junichi R. Sakaki,Ock K. Chun 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.8
Endocrine disrupting chemicals (EDCs) are aheterogenous group of compounds dispersed throughout theenvironment that possess the ability to alter endocrine systemfunction. While there are numerous routes of exposureto EDCs, the predominant source of many of these compoundsis diet, largely due to their widespread use in foodcontact materials. In recent years, there has been a surgeof research aimed at assessing exposure to EDCs, identifyingtheir health implications, and developing approaches tominimize the risks they may entail. Due to their antioxidantand anti-infl ammatory potential, polyphenols have beenpurported to confer protection against EDC-induced healthdetriments. This review discusses the evidence pertaining todietary exposure to the two predominant EDCs, bisphenol Aand phthalates, in the United States, their associations withdiabetes, cancer, and cardiovascular disease outcomes, thepotential for polyphenols to mitigate their disease-promotingeff ects, gaps in knowledge, and recommendations for futureresearch.