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Masaki Nishiguchi,Hiroki Kikuyama,Tetsufumi Kanazawa,Atsushi Tsutsumi,Takao Kaneko,Hiroyuki Uenishi,Yasuo Kawabata,Seiya Kawashige,Jun Koh,Hiroshi Yoneda 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.4
ObjectiveaaElectroconvulsive therapy (ECT) is a reasonable option for intractable depression or schizophrenia, but a mechanism of action has not been established. One credible hypothesis is related to neural plasticity. Three genes (Oct4, Sox2, c-Myc) involved in the induction of induced pluripotent stem (iPS) cells are Wnt-target genes, which constitute a key gene group involved in neural plasticity through the TCF family. Klf4 is the other gene among Yamanaka’s four transcription factors, and increases in its expression are induced by stimulation of the canonical Wnt pathway. MethodsaaWe compared the peripheral blood gene expression of the four iPS genes (Oct4, Sox2, c-Myc, and Klf4) before and after modified ECT (specifically ECT with general anesthesia) of patients with intractable depression (n=6) or schizophrenia (n=6). Using Thymatron ten times the total bilateral electrical stimulation was evoked. ResultsaaBoth assessments of the symptoms demonstrated significant improvement after mECT stimulation. Expression of all four genes was confirmed to increase after initial stimulation. The gene expression levels after treatment were significantly different from the initial gene expression in all twelve cases at the following treatment stages: at the 3rd mECT for Oct4; at the 6th and 10th mECT for Sox2; and at the 3rd, 6th and 10th mECT for c-Myc. ConclusionaaThese significant differences were not present after correction for multiple testing; however, our data have the potential to explain the molecular mechanisms of mECT from a unique perspective. Further studie should be conducted to clarify the pathophysiological involvement of iPS-inducing genes in ECT.
Masaki Imanaka,Hideki Sasamoto,Jumpei Baba,Naoto Higa,Masanori Shimabuku,Ryota Kamizato 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
In remote islands, due to expense of existing generation systems, installation of photovoltaic cells (PVs) and wind turbines has a chance of reducing generation costs. However, in island power systems, even short-term power fluctuations change the frequency of grids because of their small inertia constant. In order to compensate power fluctuations, the authors proposed the power consumption control of pumps which send water to tanks. The power control doesn’t affect water users’ convenience as long as tanks hold water. Based on experimental characteristics of a pump system, this paper shows methods to determine reference power consumption of the system with compensation for short-term PV fluctuations while satisfying water demand. One method uses a PI controller and the other method calculates reference power consumption from water flow reference. Simulations with a PV and a pump system are carried out to find optimum parameters and to compare the methods. Results show that both PI control method and water flow calculation method are useful for satisfying the water demand constraint. The water demand constraint has a little impact to suppression of the short-term power fluctuation in this condition.
Masaki Onoyama,Takeshi Tsuka,Tomohiro Imagawa,Tomohiro Osaki,Saburo Minami,Kazuo Azuma,Kazuhiko Kawashima,Hiroshi Ishi,Takahiro Takayama,Nobuhiko Ogawa,Yoshiharu Okamoto 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
Sixteen cases of malignant soft tissue sarcoma (STS; 10canines and six felines) were treated with a novel tripletherapy that combined photodynamic therapy, hyperthermiausing indocyanine green with a broadband light source, andlocal chemotherapy after surgical tumor resection. This tripletherapy was called photodynamic hyperthermal chemotherapy(PHCT). In all cases, the surgical margin was insufficient. Inone feline case, PHCT was performed without surgicalresection. PHCT was performed over an interval of 1 to 2 weeksand was repeated three to 21 times. No severe side effects,including severe skin burns, necrosis, or skin suture rupture,were observed in any of the animals. No disease recurrence wasobserved in seven out of 10 (70.0%) dogs and three out of six(50.0%) cats over the follow-up periods ranging from 238 to1901 days. These results suggest that PHCT decreases the riskof STS recurrence. PHCT should therefore be considered anadjuvant therapy for treating companion animals with STS inveterinary medicine.