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RISS 인기검색어
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- 저자 : Marzony, Eisa Tahmasbpour (검색결과 2 건)
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Orang, Elahe,Marzony, Eisa Tahmasbpour,Afsharfard, Aboulfazl Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: Breast cancer is the most common cancer among women worldwide. The aim of this study was to investigate the relationship between tumor size and axillary lymph node involvement (ALNI) in patients with invasive lesions, to find the best candidates for a full axillary dissection. Additionally, we evaluated the association between tumor size and invasive behavior. The study was based on data from 789 patients with histopathologically proven invasive breast cancer diagnosed in Shohada University hospital in Tehran, Iran (1993-2009). Cinical and histopathological characteristics of tumors were collected. Patients were divided into 6 groups according to primary tumor size: group I ($0.1-{\leq}1cm$), II ($1.1-{\leq}2cm$), III ($2.1-{\leq}3cm$), IV ($3.1-{\leq}4cm$), V ($4.1-{\leq}5cm$) and VI (>5cm). The mean(${\pm}SD$) size of primary tumor at the time of diagnosis was $3.59{\pm}2.69$ cm that gradually declined during the course of study. There was a significant correlation between tumor size and ALNI (p<0.001). A significant positive correlation between primary tumor size and involvement of surrounding tissue was also found (p<0.001). The mean number of LNI in group VI was significantly higher than other groups (p<0.05). We observed more involvement of lymph nodes, blood vessels, skin and areola-nipple tissue with increase in tumor size. We found 15.3% overall incidence of ALNI in tumors ${\leq}2cm$, indicating the need for more investigation to omit full axillary lymph node dissection with an acceptable risk for tumors below this diameter. While in patients with tumors ${\geq}2cm$, 84.3% of them had nodal metastases, so the best management for this group would be a full ALND. Tumor size is a significant predictor of ALNM and involvement of surrounding tissue, so that an exact estimation of the size of primary tumor is necessary prior to surgery to make the best decision for management of patients with invasive breast cancer.
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Atefeh-Sadat Hosseintabar Marzoni,Abbas Moghimbeigi,Javad Faradmal 질병관리본부 2015 Osong Public Health and Research Persptectives Vol.6 No.2
Objectives: Recent studies of esophageal cancer (EC) and gastric cancer (GC) have been reported to have high incidence rates of these cancers in Golestan Province of Iran. The present study describes the geographical patterns of EC and GC incidence based on cancer registry data and display statistically significant regions within this province. Methods: In order to map the distribution of upper gastrointestinal cancer, relative risk (RR) were calculated. Therefore, to estimate a more reliable RR, Poisson regression models were used. The adjusted models (adjusted to urban-rural area, sex, and grouped age proportion) were utilized. We considered twocomponent random effects for each observation, an unstructured (noncorrelated) and a group of “neighbor” (correlated) heterogeneities. We estimated the model parameters using Gibbs sampling and empirical Bayes method. We used EC and GC data that were registered with Golestan Research Center of Gastroenterology and Hepatology in the years 2004-2008. Results: The EC and GC maps were drawn for 2004-2008 in the province. Kalaleh and Minoodasht counties have a high RR of EC and GC in the years of study. In almost all years, the areas with a high RR were steady. Conclusion: The EC and GC maps showed significant spatial patterns of risk in Golestan province of Iran. Further study is needed to multivariate clustering and mapping of cancers RRs with considering diet and socioeconomic factors.
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