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Electrochemical methods to enhance osseointegrated prostheses
Mark T. Ehrensberger,Caelen M. Clark,Mary K. Canty,Eric P. McDermott 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
Osseointegrated (OI) prosthetic limbs have been shown to provide an advantageous treatment option for amputees. In orderfor the OI prosthesis to be successful, the titanium implant must rapidly achieve and maintain proper integration with thebone tissue and remain free of infection. Electrochemical methods can be utilized to control and/or monitor the interfacialmicroenvironment where the titanium implant interacts with the biological system (host bone tissue or bacteria). This reviewwill summarize the current understanding of how electrochemical modalities can infl uence bone tissue and bacteria withspecifi c emphasis on applications where the metallic prosthesis itself can be utilized directly as a stimulating electrode forenhanced osseointegration and infection control. In addition, a summary of electrochemical impedance sensing techniquesthat could be used to potentially assess osseointegration and infection status of the metallic prosthesis is presented.