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- 저자 : Mariya Lazdina (검색결과 2 건)
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Anzhela Shurshina,Mariya Afanasyeva,Valentina Chernova,Mariya Lazdina,Elena Kulish 한국고분자학회 2024 Macromolecular Research Vol.32 No.3
The work is devoted to the creation of liquid and soft gel dosage forms of prolonged action. The main task to be solved in the work was to give certain rheological characteristics (namely, pseudoplastic behaviour and pronounced yield strength) to dosage forms based on solutions of pectin, sodium salt of carboxymethylcellulose and sodium salt of chitosan succinate, namely. The study has found that the effect of prolonging the release of the medicinal substance cefazolin from liquid and soft dosage forms based on polysaccharides is directly related to the rheological characteristics of the system and can manifest itself in two cases. First, it is possible for liquid dosage forms in the area of polymer concentrations in solution lower than the concentration at which the cell of meshes C < Ce is formed. In this case, with an increase in the polymer concentration, there is a decrease in the rate of the drug substance release, due to an increase in the adduct of the polymer-drug reaction Secondly, it is possible for soft gel forms in the region of concentrations greater than the concentration at which the cell of meshes C < Ce is formed, when using additives capable of ionotropic gel formation. Calcium and zinc salts were used as such additives in the work. It is in the case when the modifying additive is capable of forming a “bridging” bond between macromolecules and the gel formation is not accompanied by a decrease in the amount of the complex adduct of the reaction, there is a prolongation effect. If the gel is only formed by increasing the polymer content in the solution without the use of an additive, the compression of macromolecular tangles and the strengthening of intramolecular interaction between the polymer units in a concentrated solution results in a significant decrease in the amount of the polymer-drug reaction adduct and accelerated the drug release from the soft dosage form.
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The possibility of using dibasic acids as regulators of chitosan transport properties
S. Anzhela Shurshina,N. Timur Mukhamedyarov,G. Lyudmila Kuzina,Yu. Mariya Lazdina,Elena Kulish 한국고분자학회 2023 Macromolecular Research Vol.31 No.9
Recently, a significant number of works have appeared devoted to the creation of materials with controlled delivery of drugs. The most promising polymers for these purposes are polysaccharides, in particular chitosan. Unfortunately, film materials obtained from a solution based on chitosan in salt form are soluble in water. In this regard, the purpose of this work was to consider the possibility of modifying the chitosan film materials. Sodium sulfate, phosphoric, succinic, and oxalic acids were chosen as polymer material modifiers. It was shown that the introduction of sodium sulfate, phosphoric, and oxalic acids leads to the loss of solubility of the film materials, changes of the shape of the sorption curve and decrease in the values of the diffusion coefficients of water vapor occurs. The introduction of a weak dibasic succinic acid as a modifier does not lead to a change in the process of sorption regime. The similar regularities are founded in the study of the process of drug release from the polymer material. Thus, fundamentally possible ways of regulating the transport properties of the chitosan film material with respect to the yield of drugs have been found, which consist in the modification of chitosan with anions of strong polybasic acids.
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