http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Mahmoud E. Soliman (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Protein nanoparticles as natural drugs carriers for cancer therapy
Sara Zaher,Mahmoud E. Soliman,Mahmoud Elsabahy,Rania M. Hathout 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.4
Nanoscale drug carriers are useful in improving the bioavilability, targeting delivery, and controlling the release of the loaded drug. Polymers from natural sources possess favourable properties such as adaptability and safety for usage as nanosized drug delivery carriers and as substitutes of synthetic polymers. The use of a biomaterial imparts special biopharmaceutical characteristics to the formulation and changes the pharmacokinetic and pharmacodynamic profile of the entrapped medication. Proteins appear as promising raw materials in this approach because of their extensive availability from renewable sources, low cost, and ability to be chemically modified, ligand conjugation and degraded into harmless by-products. Furthermore, protein nanocarriers have several benefits, including high drug-binding capability and specific tumour targeting using different ligands. This review discusses the properties of different protein biopolymers such as albumin, gelatin, zein, gliadin, casein, collagen, elastin and whey protein. The study focuses on the most relevant applications of the protein nanoparticles loading agents with antitumeric effect. Furthermore, the review summarises the primary findings of tumour-targeted protein nanoparticles in vitro and in vivo studies.
-
Polysaccharide-based platforms for nasal delivery: design, features, and perspectives
Elmowafy Enas,Soliman Mahmoud E. 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.5
Background Polysaccharides acceded by the Food and Drug Administration are among the most exploitable polymers for fabricating nasally applied vehicles containing therapeutically active molecules. Such delineation can revolutionize brain targeting, localized or systemic prospects, and improve immunity, including anti-SARS-CoV-2. Their successful implementation relies on their biocompatibility, biodegradability, muco-adhesion and penetration enhancement, and targetability traits. Area covered This review highlights the utilization of various polysaccharides as integral components in formulating nasally deliverable platforms, including nanoparticles, microparticles, in situ gels, and nasal inserts. Data from earlier works were considered to summarize the source and features of polysaccharides, derivatization, and the outcomes of the delivery systems in the nasal delivery arena. Moreover, we highlighted the potential fabrication of carriers based on compositionally modified surfaces using polysaccharides or hybrid complex formation, and their assay and outcomes. Issues related to large-scale production and efficacy in clinical practice were addressed. Expert opinion Current advances in polysaccharide-based vehiculation for nasal applications is highly satisfying and could have promising preclinical prospects. Based on their abundance, safety, delivery to the desired site, and applicable dose, these delivery platforms must be studied further. Specifically, ongoing efforts to design nasal vaccines to address the continuously emerging respiratory viruses requires thorough understanding of storage conditions and toxicological profiles. The price of medical devices and clinical approval measures must also be considered. Collectively, more extensive research is required to improve the clinical translation and commercialization of these polymers.
-
Enas M. Elmowafy,Mattia Tiboni,Mahmoud E. Soliman 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.4
Background Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are among the well-documented FDAapproved polymers used for the preparation of safe and effective vaccine, drug and gene delivery systems using well-described reproducible methods of fabrication. Various nano and microparticulates are fabricated using these polymers. Their successful performance relies on PLA and PLGA biocompatibility and degradability characteristics. Area covered This review provides an overview of the biocompatibility and biodegradation of PLA, PLGA and their copolymers, with a special emphasis on tissue responses for these polymers as well as their degradation pathways and drug release models. Moreover, the potential of PLA and PLGA based nano and microparticulates in various advanced biomedical applications is highlighted. Expert opinion PLA and PLGA based delivery systems show promises of releasing different drugs, proteins and nucleic acids in a stable and controlled manner and greatly ameliorating their therapeutic efficacy. In addition, advancement in surface modification and targeting of nanoparticles has extended the scope of their utility.
-
Khaled S. Shamarekh,Heba A. Gad,Mahmoud E. Soliman,Omaima A. Sammour 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.2
Purpose The aim of the present study was to prepare gelatin nanoparticles (GNPs) using modified one step desolvation method to obtain small, uniformly sized, and spherical GNPs. Methods The modifications involved the preparation of high molecular weight gelatin (HMWG) by fractionation of gelatin. HMWG was freeze-dried to be used in a specified concentration for preparation of GNPs with controllable properties. Furthermore, HMWG was cationized by dissolving it in acidified deionized water at pH value less than its isoelectric point. Factorial design analysis was utilized to investigate the effect of different preparation variables (viz. HMWG concentration, pH and ratio of HMWG solution volume to non-solvent volume) on particle size, polydispersity index (PDI), zeta potential and yield of GNPs. Results Results revealed the formation of monodisperse GNPs with small particle size, low PDI values (< 0.2) and high yield. FT-IR spectroscopy and differential scanning calorimetry studies revealed that the conformational structure of HMWG chains was altered within GNPs matrices. Conclusion The suggested modifications introduced on the one-step desolvation method enable to prepare successfully monodispersed GNPs with narrow size distribution and high particle yield.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
