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RISS 인기검색어
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- 저자 : Mahdi Taheri (검색결과 3 건)
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Mahdi Ghelichi,Nader Taheri Qazvini,Seyed Hassan Jafari,Hossein Ali Khonakdar 한국고분자학회 2013 Macromolecular Research Vol.21 No.4
The influence for the minor amount of sodium montmorillonite (Na+-MMT) nanoclay on the thermorheological complexity of a miscible blend of 20 wt% poly(ethylene oxide) (PEO) in poly(methyl methacrylate)(PMMA) is studied. The dispersion of Na+-MMT in the PEO/PMMA is assessed via X-ray diffraction. The empirical principle of time-temperature superposition is found to be partially restored in the case of blend nanocomposite,whereas it fails for the neat PEO/PMMA blend. The relaxation times of each component are determined from the oscillatory shear rheometry data in the form of a monomeric friction coefficient. The chain dynamics of components is coupled in the presence of hydrophilic nanoclay, which preferentially adsorbs PEO. The self-concentration model of Lodge and McLeish successfully describes the temperature dependence of the PMMA monomeric friction coefficient in both the neat and blend nanocomposite in regards to the temperature range studied.
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Immunogenicity of glycine nanoparticles containing a chimeric antigen as Brucella vaccine candidate
Ghazal karevan,Kazem Ahmadi,Ramezan Ali Taheri,Mahdi Fasihi-Ramandi 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.1
Purpose: Brucellosis as a worldwide zoonotic illness affect domestic animals and humans doesn’t have any vaccine for the prevention of infection in humans yet. The aim of this study was to evaluate the specific immune response following the administration of glycine nanoparticles as adjuvant and delivery system of a chimeric antigen contained trigger factor, Omp31, and Bp26 in murine model. Materials and Methods: The chimeric antigen of Brucella was cloned and expressed in Escherichia coli (E. coli) BL21 (DE3). Purification and characterization of recombinant protein was conducted through Ni-NTA (nickel-nitrilotriacetic acid) agarose, SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis), and Western blot. Nanoparticle characteristics including morphology, particle size distribution, zeta potential, protein retention rate, and release rate were measured in vitro. Subsequently, nanoparticle contained antigen was administered to mice and blood sample was taken to measured the antibody level. Results: The protein retention in the nanoparticles was successfully done and the nanoparticle characteristics were appropriate. The average size of glycine particles containing antigen was about 174 nm, and the absorption of protein was approximately 61.27% of the initial value, with a release rate of approximately 70% after 8 hours. Enzyme-linked immunosorbent assay result proved that the immunized sera of mice which were administered with nano-formula contains high levels of antibodies (immunoglobulin G) against recombinant chimeric antigen and also a high level of mucosal antibody (immunoglobulin A) in the oral group, which showed a desirable immunity against Brucella. Conclusion: The results showed that chimeric antigen-loaded glycine nanoparticles can act as a vaccine candidate for inducing the cellular and humoral immune response against brucellosis.
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