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RISS 인기검색어
- 검색키워드
- 저자 : Maghsoudpour Adel (검색결과 2 건)
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Mohammadhossein Shahsavari Alavijeh,Adel Maghsoudpour,Morteza Khayat,Iman Rad,Shadie Hatamie 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.3
The aims were to characterize MoS 2 /CoFe 2 O 4 nanocomposite and investigate its thermal therapy efficiency on cancerous (MCF-7) and normal (MCF-10A) human breast cells. Magnetic nanocomposites (MNCs) characterized by scanning/transmission electron microscopy (SEM/TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM) techniques. TEM and SEM techniques showed MoS 2 /CoFe 2 O 4 MNCs had an average size of 17±4 nm with almost spherical morphology. Magnetic properties of MNC measured by VSM, which resulted in specific loss power (SLP) of 766.61 W/g at 300 K. Cytotoxicity of MoS 2 /CoFe 2 O 4 nanocomposites in MCF-7 and MCF-10A cell lines remained insignificant until 48 hours, which confirms its biocompatibility. Low concentration (200 µg/mL) of MoS 2 /CoFe 2 O 4 was exposed to the low-frequency alternative magnetic field (f = 150 kHz, H = 31.16 mT) in a way that delivery of thermal ablation via magnetic fluid hyperthermia (MFH) occurred exclusively in cancerous (MCF-7) cells.
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Shahsavari Alavijeh Mohammadhossein,Maghsoudpour Adel,Khayat Morteza,Rad Iman,Hatamie Shadie 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.6
Purpose Aims were to investigate pattern of distribution of “molybdenum disulfide/cobalt ferrite” magnetic nanocomposite (MNC), following injection into the BALB/c mice tumor. Methods MNCs were characterized by microscopic, spectroscopic and magneto-metric techniques. To have a gland tumor, 4T1 cells injected subcutaneously. After 1 week of tumor growth, MNCs injected to the tumor at different speed rates, and tumor size monitored after magnetic fluid hyperthermia (MFH) by seven days via measurement of tumors’ outer dimensions, histopathology and qRT-PCR assay techniques. Results Neither MoS2/ CoFe2O4 nor applied alternative magnetic field (AMF) diminished viability of tumor cells. However, when concentration of 200 μg/ml injected by speed rate of 10 μl/min to the tumor in the presence of AMF (f = 150 kHz, H = 31.16 mT), significant diminution of tumor size and considerable raise of tumor necrosis observed. At the same time, up-regulation of Bax and p53, and down-regulation of VEGF and Bcl2 was detected. Conclusion Uniform distribution of MNC in optimized condition resulted in significant diminution of tumor size after MFH. Besides, injection of MoS2/ CoFe2O4 to the tumor left no sign of necrosis or inflammation in the mice liver. These features of MoS2/ CoFe2O4 introduce it as a promising candidate for further clinical studies.
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