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- 저자 : Maerten, P. (검색결과 2 건)
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Maerten, P.,Kwon, B. S.,Shen, C.,De Hertogh, G.,Cadot, P.,Bullens, D. M. A.,Overbergh, L.,Mathieu, C.,Van Assche, G.,Geboes, K.,Rutgeerts, P.,Ceuppens, J. L. Blackwell Science Ltd 2006 Clinical and experimental immunology Vol.143 No.2
<P>Summary</P><P>4-1BB ligand (4-1BBL) expressed on antigen-presenting cells interacts with 4-1BB on activated T cells (especially CD8<SUP>+</SUP> cells) and co-stimulates the latter to secrete cytokines and to proliferate. The role of 4-1BB−4-1BBL interaction was studied here in a model of colitis based on naive CD4<SUP>+</SUP> T cell transfer to SCID mice, a disease model in which CD8 cells do not take part. We found that CD4<SUP>+</SUP> T cells from 4-1BB-deficient mice, after transfer in SCID mice, proliferated more rapidly compared to wild-type CD4<SUP>+</SUP> T cells. Mice reconstituted with naive CD4<SUP>+</SUP> T cells from 4-1BB-deficient mice developed colitis, however, with a mixed Th1/Th2 response, in contrast to the Th1-type response in mice reconstituted with wild-type naive CD4<SUP>+</SUP> T cells. Importantly, this altered cytokine response did not temper colitis severity. Although it has been reported previously that 4-1BB co-stimulation may contribute to regulatory T cell functioning, we found that CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells from 4-1BB-deficient mice were perfectly able to prevent naive CD4<SUP>+</SUP> T cell-induced colitis. In conclusion, our data provide evidence that 4-1BB−4-1BBL interaction modulates the effector CD4<SUP>+</SUP> T cell-driven immune response and cytokine production in experimental colitis without affecting regulatory T cell function.</P>
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Judith Janna Maertens 한국법제연구원 2020 KLRI journal of law and legislation Vol.10 No.1
The relationship between the European Constitutional Courts and the European Court of Human Rights in the multilevel system of human rights protection has been discussed intensively. In fact, the ECtHR has a strong influence on the German Constitutional Court and vice versa the ECtHR has been strongly paid attention to the German jurisprudence. Gradually, a steady cooperation between the courts has been developed. The article will explain how German Basic Rights were redefined by the case law of the ECtHR. The development of the right of privacy and the right of self-determination under Article 8 ECHR and the corresponding general right of personality in German law will illustrate the impact of the ECtHR’s jurisprudence in German law. In this respect, the article will discuss the cases Von Hannover v. Germany in order to show privacy protection against the media. Then, the case Koch v. Germany will clarify the scope of self-determination regarding the right to die in dignity. Finally, the article will argue that the ECtHR’s case law and the domestic jurisprudence are interwoven in a complex system of human rights protection and that the cooperation of the courts is substantial for an effective protection system of human rights in Europe.
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