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A New Potent Angiogenesis Inhibitor, FR-118487
TAKANAO, OTSUKA,OHKAWA, TAKEHIKO,SHIBATA, TOSHIHIRO,OKU, TERUO,OKUHARA, MASAKUNI,TERANO, HIROSHI,MASANOBU KOHSAKA,IMANAKA, HIROSHI 한국미생물 · 생명공학회 1991 Journal of microbiology and biotechnology Vol.1 No.3
A new angiogenesis inhibitor, FR-118487 was obtained by chemical modification of FR-111142 which was isolated from the fermentation products of Scolecobasidium arenarium F-2015. The antiangiogenic activity of FR-118487 was compared with that of the parent compound, FR-111142. In the endothelial cell proliferation test in vitro and the anglogenesis in the chick embryo chorioallantoic membrane assay, FR-118487 had about 5∼10 times stronger antiangiogenic activities than FR-111142. In addition, FR-118487 inhibited the angiogenesis in the rabbit corneal assay and suppressed the solid tumor growth in mice. These findings showed that FR-118487 would be a unique antiangiogenic agent with promising antitumor activity.