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RISS 인기검색어
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- 저자 : MAMOUN MUHAMMED (검색결과 2 건)
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Nanostructured Materials and Nanotechnology : Overview
Muhammed, Mamoun,Tsakalakos, Thomas The Korean Ceramic Society 2003 한국세라믹학회지 Vol.40 No.11
Nanostructured materials can be engineered by the controlled assembly of several suitable nano-objects as the building blocks. While, materials properties are determined by their atomic and molecular constituents and structure, their functionalities emerge when the microstructure of these early ensembles is in the nanometer regime. The properties and functionalities of these ensembles may be different as their size grows from the nano-regime to the micron regime and bulk structures. Nanotechnology, offers a unique possibility to manipulate the properties through the fabrication of materials using the nano-objects as building blocks. Nanotechnology is therefore considered an enabling technology by which existing materials, virtually all man-made materials, can acquire novel properties and functionalities making them suitable for numerous novel applications varying from structural and functional to advanced biomedical in-vivo and in-vitro applications.
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ÅSA BARREFELT,MOUSTAPHA HASSAN,HEBA ASEM,PETER ASPELIN,TORKEL B. BRISMAR,GAIO PARADOSSI,SILVIA MARGHERITELLI,MARYAM SAGHAFIAN,LETIZIA ODDO,MAMOUN MUHAMMED 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.6
Magnetic Resonance Imaging (MRI) is a noninvasive diagnostic method that provides informa-tion on morphological and physiological changes of the internal organs over time. Imaging andmeasurements can be repeated on the same subject, thereby reducing inter-individual variabilitye®ects and hence the number of subjects required. A potential MRI contrast agent consisting ofmicrobubbles embedded with superparamagnetic iron oxide nanoparticles (SPION) in the shell(SPION MBs) was injected intravenously into rats to determine their biodistribution andpharmacokinetics using MR imaging. Agarose phantoms containing SPION MBs were scannedusing 3 T MRI to construct a standard curve. Rats were injected with SPION MBs, free SPIONor plain MBs and scanned dynamically at 3 T using a clinical MR scanner. The relaxation rate(R2*) was studied over time as a measure of the iron oxide concentrations to enable calculation ofthe pharmacokinetic parameters. The kinetics of SPION MBs in the liver was ¯tted to a one-compartment model. Furthermore, the biological fate of SPION MBs was examined via a his-tological survey of tissue samples using Perls' Prussian blue staining and immunohistochemistry(IHC). 1.2 h after injection of SPION MBs, T2* of the liver had decreased to its minimum. Theelimination half-life of SPION MBs was 598 : 2 ? 97 : 3 h, while the half-life for SPION was222 : 6 ? 26 : 4 h. Moreover, our study showed that SPION MBs were taken up by the macrophagesin the lungs, spleen and liver. MBs labeled with SPION can be used for MR imaging. Moreover,MRI is a reliable and noninvasive tool that can be utilized in pharmacokinetic investigations offuture contrast agents using SPION MBs and SPION in the rat.
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