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RISS 인기검색어
- 검색키워드
- 저자 : M. Ekramul Haque (검색결과 2 건)
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Analgesic and anti-inflammatory activities of Alocasia indica (Roxb.) Schott
Atiqur Rahman,M. Solaiman,Ekramul Haque,A. K. Das 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
The ethanol extract of the dried rhizome of Alocasia indica (Roxb.) Schott. (Family - Araceae) was investigated for its possible analgesic and antiinflammatory activities in animal models. The extract showed significant (P<0.001) writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 300 and 600 mg/kg of body weight comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. Moreover, when given orally to rats at dose of 300 and 600 mg/kg of body weight, the extract showed a significant (P<0.001) anti-inflammatory activity against carrageenin induced paw edema in rats which was comparable to the standard drug aspirin at the dose of 150 mg/kg of body weight. The overall results tend to suggest the analgesic and anti-inflammatory activities of the crude ethanolic extract of dried rhizome of Alocasia indica (Roxb.) Schott. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
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Farjana Nikkon,M. Rowshanul Habib,M. Rezaul Karim,M. Shamim Hossain,M. Ashik Mosaddik,M. Ekramul Haque The Korean Society of Mycology 2008 Mycobiology Vol.36 No.3
The crude ethanol extracts (stem and fruits), their fractions and two triterpenes, β-Amyrin and 12-Oleanene 3β, 21β-diol, isolated as a mixture from the chloroform soluble fraction of an ethanolic extract of Duranta repens stem, were evaluated for antibacterial, antifungal activities by the disc diffusion method and cytotoxicity by brine shrimp lethality bioassay. The structures of the two compounds were confirmed by IR, 1H-NMR, 13C-NMR and LC-MS spectral data. The chloroform soluble fraction of stem and ethanol extract of fruits possess potent antishigellosis activity and also exhibited moderate activity against some pathogenic bacteria and fungi but the isolated compound 1 (mixture of β-Amyrin and 12-Oleanene 3β, 21β-diol) showed mild to moderate inhibitory activity to microbial growth. The minimum inhibitory concentrations (MICs) of the extracts (stem and fruits), their fractions and compound 1 were found to be in the range of 32~128 μg/ml. The chloroform soluble fractions of stem and ethanol extract of fruit showed significant cytotoxicity with LC50 value of 0.94 μg/ml and 0.49 μg/ml, respectively against brine shrimp larvae.
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