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The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
Mădălina Georgiana Albu,Laura-Cristina Rusu,Mihaela Violeta Ghica,Durmuș Alpaslan Kaya,Lăcrămioara Popa,Şevket Öztürk,Cristina Dinu-Pîrvu,Ciprian Chelaru,Luminița Albu,Aurelia Meghea,Cornelia Nitipir 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.4
The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
Maria Demeter,Ion Călina,Cătălin Vancea,Murat Şen,Mădălina Georgiana Albu Kaya,Elena Mănăilă,Marius Dumitru,Viorica Meltzer 한국고분자학회 2019 Macromolecular Research Vol.27 No.3
Collagen (C)-poly(N-vinyl-2-pyrrolidone) (PVP) double-network superabsorbent hydrogels were synthesized by e-beam (electron beam) radiation processing, both with the addition of water-soluble cross-linking agents (CA), as well as without CA. The aim of the study was to develop a hydrogel for future application as wound dressings via e-beam radiation cross-linking of two biocompatible polymers. The formation of C-PVP hydrogels was confirmed by Fourier transform infrared (FTIR) spectroscopy and their performance was determined from morphological and rheological experiments, such as sol-gel analysis, swelling capacity, storage (G') and viscous (G'') moduli, cross-linking density, and pore size. Sol-gel analysis was performed in order to determine the gel properties as function of absorbed dose and it was found that the degradation density (p0)/cross-linking density (q0) ratio indicates a negligible contribution of chain scission processes. The rheological data confirmed that the elastic properties were predominant: G' moduli were larger than G'' moduli, as is specific to elastic solids and indicate the formation of a permanent hydrogel network were cross-links are present. Moreover, the swelling studies indicated that the hydrogels have good stability both in deionized water and phosphate-buffered saline (PBS) solution at 37 oC, and superabsorbent properties. The hydrogels network parameters obtained with lower content of CA, could be controlled by changing the absorbed dose.