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Douglas de Britto,Marcia R. de Moura,Fauze A. Aouada,Flávia G. Pinola,Lícia M. Lundstedt,Odilio B. G. Assis,Luiz H. C. Mattoso 한국고분자학회 2014 Macromolecular Research Vol.22 No.12
Nanoencapsulation is a process suitable for use in reducing degradation of instable components. In thisstudy, chitosan and trimethyl chitosan with tripolyphosphate were used to nanoencapsulate vitamins C, B9, and B12. Analysis of the particle size showed that for a fix proportion of the polymer tripolyphosphate, the system showed awide variation in size with the amount of added vitamins: e.g., for vitamin B9, the particle size varied from 150±5nm to 809±150 nm. The zeta potential confirmed that trimethyl chitosan nanoparticles generally had a lower net positivecharge (20 mV) than chitosan nanoparticles (40 mV). The encapsulation efficiency was found to be dependenton nanoparticle structure and vitamin solubility, with vitamin B9 the most efficiently encapsulated (approximately40%). UV-Visible spectroscopy indicated different release profiles for vitamins C, B9, and B12 in a neutral PBSsolution with release rates of 36%, 52%, and 16% after 2, 24, and 4 h, respectively. In conclusion the liberation wasfound to be slower in acidic media.