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      • PRODUCTION OF A LAURIC ACID SUPPLEMENT TO LOWER THE AMOUNT OF LOW-DENSITY LIPOPROTEINS

        Patricia Rochelle O. Gan,Louise Joy A. Martin,Paula Nadine L. Sanchez,Ms. Ana Victoria Lloren 국제과학영재학회 2012 APEC Youth Scientist Journal Vol.4 No.-

        This project produced a lauric acid mixture consisting of lauric acid and non-fat milk, which contained components that lowered the cholesterol to HDL-LDL ratio in the system. This was done to pinpoint its effects on blood cholesterol levels in the hopes of lowering the amount of plaque found in the blood vessels. In the feasibility study, three out of the prospective twelve mice (4 groups of 3 mice) were given treatments of 2.00 mg lauric acid per 2.00 mL milk. The control mouse was given no lauric acid. After acclimatization, atherosclerosis was induced by feeding all mice 1.00 gram of butter per mice per day for two weeks. Blood was then extracted from the saphenous vein of the control mouse. After a month of treatment, blood was again extracted. The LDL-C (low density lipoprotein-cholesterol) ratios ranged from 1.90 to 18.3 from an initial 37.9 and the HDL-C (high density lipoproteins-cholesterol) ratios ranged from 19.4 to 28.4 from an initial 34.6. The t-tests (α = 0.05) show that there is a significant difference between the initial and final levels, which may then lead to the creation of a supplement that will lessen the susceptibility of atherosclerosis in humans.

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