Assessment of nephrotoxicity of herbal medicine containing aristolochic acid in mice

Yi Quan,Long Jin,Kang Luo,Jian Jin,Sun Woo Lim,신유진,Eun Jeong Ko,Byung Ha Chung,Chul Woo Yang 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2

Background/Aims: It is undetermined if herbal medicines (HM) containing aristolochic acid (AA)-containing have similar nephrotoxicity to AA itself. Methods: We administered HM containing a high concentration of AA for 5 days (short-term study) or a low concentration of AA for 30 days (long-term study) to C57BL/6 mice; for comparison, same dose of AA compound was used as controls. Results: The nephrotoxicity in the HM- and AA-treated mice was compared in terms of renal function, histopathology, oxidative stress, apoptotic cell death, and mitochondrial damage. Short-term HM treatment resulted in acute kidney injury (marked renal dysfunction, acute tubular necrosis, and neutrophil gelatinase-associated lipocalin [NGAL] expression) in which the severity of renal dysfunction and histopathology was comparable with that induced by the administration of AA alone. Long-term HM treatment resulted in features of chronic kidney disease (CKD, mild renal dysfunction and tubular atrophy and dilatation). No significant differences in these parameters were observed between the HM- and AA-treated mice. HM-induced oxidative stress (8-hydroxy-2’-deoxyguanosine and manganese- dependent superoxide dismutase expression) and apoptotic cell death (terminal deoxynucleotidyl transferase dUTP nick end labelling [TUNEL]-positive cells and active caspase-3 expression) were similar in HM- and AA-treated mice in the short-term and long-term studies. Mitochondrial injury, evaluated by electron microscopy, was also similar in HM- and AA-treated mice in the short-term and long-term studies. Conclusions: The nephrotoxic potential of HM containing AA was similar to that of AA itself.

Study on the Linkage Effect between China and South Korea Stock Market

Sun Jian quan,Sun Xiao lin,Chen Xiao long 한국유통과학회 2017 KODISA ICBE (International Conference on Business Vol.2017 No.-

As the trend of the world financial integration gradually strengthen, the research of the relationship between different stock markets mean a lot to improve the capital markets. The purpose of this article is to explore the linkage effect of market between China and South Korea. There is no evidence to prove that the five variables on behalf of the Chinese stock market have any relationship with KOSPI200 index by the granger causality test. There is no co-integration relationship between two markets by using co integration test to explore the long-term stable equilibrium relationship between China and South Korea stock markets. Therefore there is no significant relationship between China and South Korea market.

Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells

Lim, Sun Woo,Jin, Long,Luo, Kang,Jin, Jian,Yang, Chul Woo Nature Publishing Group 2017 Laboratory investigation Vol.97 No.11

<P>We previously reported that long-term treatment with a calcineurin inhibitor impairs autophagy process in pancreatic beta cells. This study investigated the effect of Korean red ginseng extract (KRGE) on autophagy modulated by oxidative stress. In mice with tacrolimus (Tac)-induced diabetes mellitus, KRGE alleviated islet dysfunction and decreased oxidative stress and autophagic vacuoles. In vitro, KRGE decreased autophagosome formation and attenuated lysosomal degradation, accompanied by improved beta cell viability and insulin secretion. Addition of 3-methyladenine (3-MA), an inhibitor of autophagosomes, to KRGE further improved cell viability and insulin secretion, and bafilomycin A (BA), an inhibitor of lysosomal function, reduced the effects of KRGE. At the subcellular level, Tac caused mitochondrial dysfunction (impaired mitochondrial oxygen consumption, ATP production, and increased reactive oxygen species production). But KRGE improved these parameters. The effect of KRGE on mitochondrial function enhanced by 3-MA but decreased by BA, suggesting a causal relationship between KRGE effect and autophagy modulation in Tac-induced mitochondrial dysfunction. These findings indicate that KRGE modulates autophagy favorably by reducing Tac-induced oxidative stress, and this effect is closely associated with improvement of mitochondrial function.</P>

Surf points based Moving Target Detection and Long-term Tracking in Aerial Videos

( Juan-juan Zhu ),( Wei Sun ),( Bao-long Guo ),( Cheng Li ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11

A novel method based on Surf points is proposed to detect and lock-track single ground target in aerial videos. Videos captured by moving cameras contain complex motions, which bring difficulty in moving object detection. Our approach contains three parts: moving target template detection, search area estimation and target tracking. Global motion estimation and compensation are first made by grids-sampling Surf points selecting and matching. And then, the single ground target is detected by joint spatial-temporal information processing. The temporal process is made by calculating difference between compensated reference and current image and the spatial process is implementing morphological operations and adaptive binarization. The second part improves KALMAN filter with surf points scale information to predict target position and search area adaptively. Lastly, the local Surf points of target template are matched in this search region to realize target tracking. The long-term tracking is updated following target scaling, occlusion and large deformation. Experimental results show that the algorithm can correctly detect small moving target in dynamic scenes with complex motions. It is robust to vehicle dithering and target scale changing, rotation, especially partial occlusion or temporal complete occlusion. Comparing with traditional algorithms, our method enables real time operation, processing 520×390 frames at around 15fps.

Synchronous immobilization and conversion of polysulfides on a VO₂-VN binary host targeting high sulfur load Li-S batteries

Song, Yingze,Zhao, Wen,Kong, Long,Zhang, Li,Zhu, Xingyu,Shao, Yuanlong,Ding, Feng,Zhang, Qiang,Sun, Jingyu,Liu, Zhongfan The Royal Society of Chemistry 2018 ENERGY AND ENVIRONMENTAL SCIENCE Vol.11 No.9

<P>Lithium-sulfur (Li-S) batteries are deemed as one of the most promising next-generation energy storage systems. However, their practical application is hindered by existing drawbacks such as poor cycling life and low Coulombic efficiency due to the shuttle effect of lithium polysulfides (LiPSs). We herein present an <I>in situ</I> constructed VO2-VN binary host which combines the merits of ultrafast anchoring (VO2) with electronic conducting (VN) to accomplish smooth immobilization-diffusion-conversion of LiPSs. Such synchronous advantages have effectively alleviated the polysulfide shuttling, promoted the redox kinetics, and hence improved the electrochemical performance of Li-S batteries. As a result, the sulfur cathode based on the VO2-VN/graphene host exhibited an impressive rate capability with ∼1105 and 935 mA h g<SUP>−1</SUP> at 1C and 2C, respectively, and maintained long-term cyclability with a low capacity decay of 0.06% per cycle within 800 cycles at 2C. More remarkably, favorable cyclic stability can be attained with a high sulfur loading (13.2 mg cm<SUP>−2</SUP>). Even at an elevated temperature (50 °C), the cathodes still delivered superior rate capacity. Our work emphasizes the importance of immobilization-diffusion-conversion of LiPSs toward the rational design of high-load and long-life Li-S batteries.</P>

Self-Rearrangement of Silicon Nanoparticles Embedded in Micro-Carbon Sphere Framework for High-Energy and Long-Life Lithium-Ion Batteries

Jeong, Min-Gi,Du, Hoang Long,Islam, Mobinul,Lee, Jung Kyoo,Sun, Yang-Kook,Jung, Hun-Gi American Chemical Society 2017 Nano letters Vol.17 No.9

<P>Despite its highest theoretical capacity, the practical applications of the silicon anode are still limited by severe capacity fading, which is due to pulverization of the Si particles through volume change during charge and discharge. In this study, silicon nanoparticles are embedded in micron-sized porous carbon spheres (Si-MCS) via a facile hydrothermal process in order to provide a stiff carbon framework that functions as a cage to hold the pulverized silicon pieces. The carbon framework subsequently allows these silicon pieces to rearrange themselves in restricted domains within the sphere. Unlike current carbon coating methods, the Si-MCS electrode is immune to delamination. Hence, it demonstrates unprecedented excellent cyclability (capacity retention: 93.5% after 500 cycles at 0.8 A g(-1)), high rate capability (with a specific capacity of 880 mAh g(-1) at the high discharge current density of 40 A g(-1)), and high volumetric capacity (814.8 mAh cm(-3)) on account of increased tap density. The lithium-ion battery using the new Si-MCS anode and commercial LiNi0.6Co0.2Mn0.2O2 cathode shows a high specific energy density above 300 Wh kg(-1), which is considerably higher than that of commercial graphite anodes.</P>

Association Between XRCC1 Gene Polymorphisms and Risk of Glioma Development: A Meta-analysis

Sun, Jian-Ying,Zhang, Chun-Yang,Zhang, Zhen-Jun,Dong, Yan-Fang,Zhang, An-Long,Wang, Zhi-Wei,Mei, Xiao-Long Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: Previous studies of the association between X-ray cross-complementing group 1 (XRCC1) gene polymorphisms and the gliomas risk have yielded conflicting results, and thus a meta-analysis was performed to provide a more accurate estimation. Methods: A computerized literature search of 5 electronic databases was conducted to identify the relevant studies. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results: A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively. The pooled results showed that GlnGln carriage was associated with moderately increased risk of gliomas in Asians (GlnGln vs. ArgArg, OR=1.490, 95%CI 1.031-2.153; GlnGln/ArgGln vs. ArgArg, OR=1.321, 95%CI 1.037-1.684), whereas a marginal association was revealed in Caucasians. For the Arg194Trp polymorphism, although a significant association was shown in the homozygous genotype comparisons (TrpTrp vs. ArgArg, OR = 2.209, 95%CI 1.398-2.945), no significant link was found on subgroup analysis stratified by ethnicity. With regard to the Arg280His polymorphism, no significant association was found in each comparison. No particular study was found to significantly influence the pooled results, and no potential publication bias was detected. Conclusions: This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism is moderately associated with increased risk of gliomas in Asians, while Arg194Trp and Arg280His polymorphisms demonstrated no significant influence. Due to the limited studies and the potential confounders, further studies are needed to confirm these results.

Estimating carbon emissions from forest fires during 1980 -1999 in Daxing`an Mountain, China

( Sun Long ),( Ji Hong Kim ),( Hai Qing Hu ) 한국임학회 2012 산림과학 공동학술대회 논문집 Vol.2012 No.-

DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression

Sun, Jaw Long,Park, Jinwoo,Lee, Taeseung,Jeong, Ji Hoon,Jung, Tae Woo Elsevier 2020 Biochemical pharmacology Vol.171 No.-

<P><B>Abstract</B></P> <P>Inflammation and endoplasmic reticulum (ER) stress are associated with the development of insulin resistance and diabetes. Developmental endothelial locus-1 (DEL-1) enhances efferocytosis by macrophage and suppresses inflammatory response. However, effects of DEL-1 on ER stress-mediated insulin resistance in skeletal muscle remain unclear. Here, DEL-1 treatment augmented SIRT1 expression in C2C12 myocytes, thereby increasing SERCA2 expression in a dose-dependent fashion, and attenuated ER stress and insulin resistance under palmitate treatment condition. SIRT1/SERCA2 knockdown abrogated effects of DEL-1 on palmitate-induced insulin resistance as well as ER stress. Pharmacological significance of DEL-1 was confirmed by in vivo experiments. DEL-1 administration suppressed ER stress, insulin resistance, and SIRT1/SERCA2 expression in skeletal muscle of high-fat diet (HFD)-fed mice. Additionally, siRNA transfection-mediated in vivo downregulation of SIRT1 suppressed the effects of DEL-1 on expression of SERCA2, ER stress, and insulin resistance in skeletal muscle of HFD-fed mice. DEL-1 attenuates palmitate-induced and HFD-induced skeletal muscle ER stress and insulin resistance via SIRT1/SERCA2-mediated signaling.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Poster Session : Physiological roles of CTMP in Wolf-Hirschorn Syndrome (WHS): potential regulator and binding partner for LETM1

( Long Zhen Piao ),( Keum Jin Yang ),( Sang Hee Shin ),( Eul Soon Shin ),( Kyung Ah Park ),( Hee Sun Byun ),( Min Ho Won ),( Gang Min Hur ),( Jeong Ho Seok ),( Brian A Hemmings ),( Jong Sun Park ) 생화학분자생물학회 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-