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Bohns Fábio Rocha,Leitune Vicente Castelo Branco,Garcia Isadora Martini,Genari Bruna,Dornelles Nélio Bairros,Guterres Silvia Stanisçuaski,Ogliari Fabrício Aulo,de Melo Mary Anne Sampaio,Collares Fabrí 대한치과보존학회 2020 Restorative Dentistry & Endodontics Vol.45 No.4
Objectives: In this study, we investigated the potential of amoxicillin-loaded polymeric microspheres to be delivered to tooth root infection sites via a bioactive reparative cement. Materials and Methods: Amoxicillin-loaded microspheres were synthesized by a spray-dray method and incorporated at 2.5% and 5% into a mineral trioxide aggregate cement clinically used to induce a mineralized barrier at the root tip of young permanent teeth with incomplete root development and necrotic pulp. The formulations were modified in liquid:powder ratios and in composition by the microspheres. The optimized formulations were evaluated in vitro for physical and mechanical eligibility. The morphology of microspheres was observed under scanning electron microscopy. Results: The optimized cement formulation containing microspheres at 5% exhibited a delayed-release response and maintained its fundamental functional properties. When mixed with amoxicillin-loaded microspheres, the setting times of both test materials significantly increased. The diametral tensile strength of cement containing microspheres at 5% was similar to control. However, phytic acid had no effect on this outcome (p > 0.05). When mixed with modified liquid:powder ratio, the setting time was significantly longer than that original liquid:powder ratio (p < 0.05). Conclusions: Lack of optimal concentrations of antibiotics at anatomical sites of the dental tissues is a hallmark of recurrent endodontic infections. Therefore, targeting the controlled release of broad-spectrum antibiotics may improve the therapeutic outcomes of current treatments. Overall, these results indicate that the carry of amoxicillin by microspheres could provide an alternative strategy for the local delivery of antibiotics for the management of tooth infections.
Atoche-Socola, Katherine Joselyn,Arriola-Guillen, Luis Ernesto,Lopez-Flores, Ana Isabel,Garcia, Isadora Martini,Huertas-Mogollon, Gustavo,Collares, Fabricio Mezzomo,Leitune, Vicente Castelo Branco The Korean Academy of Prosthodonitics 2021 The Journal of Advanced Prosthodontics Vol.13 No.4
PURPOSE. This study aimed to compare the microshear bond strength (µSBS) of dual-cure resin cement in CAD-CAM zirconia after different cleaning techniques. MATERIALS AND METHODS. Fifty discs of zirconia-based ceramic from Ivoclar Vivadent were embedded in acrylic resin. The discs were divided into five groups according to the cleaning methods used: Group 1: drying with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub>; Group 2: washed with water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub>;Group 3: washed with distilled water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub> + zirconium oxide (Ivoclean); Group 4: washed with distilled water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub> + potassium hydroxide (Zirclean); and Group 5: washed with distilled water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub> + 1% NaClO. All of the groups were contaminated with artificial saliva for 1 minute and then cleaned. Statistical analyses were performed using ANOVA and Tukey's tests. RESULTS. There were statistically significant differences among all groups for µSBS (P < .05). The group treated with zirconium oxide (Group 3) showed the highest µSBS (18.75 ± 0.23 MPa). CONCLUSION. When applied to zirconia, the cleaning methods affected the bonding with resin cement differently.