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Larouci, Cherif,Ejjabraoui, Kamal,Lefranc, Pierre,Marchand, Claude The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2
This paper deals with an optimization approach of 3D space placement of power components under volume and thermal constraints. It consists in optimizing semiconductors positions on a heat sink by respecting the components junction temperatures and minimizing the heat sink size. The aim is to remove risks on the 3D converter components placement and ensure their effective integration before carrying out the first physical prototype. This approach is based on coupling an optimization environment with a thermal finite element simulation tool. A pre-sizing step using analytical models is performed to set the optimization computations coupled to numerical simulation.
Cherif Larouci,Kamal Ejjabraoui,Pierre Lefranc,Claude Marchand 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2
This paper deals with an optimization approach of 3D space placement of power components under volume and thermal constraints. It consists in optimizing semiconductors positions on a heat sink by respecting the components junction temperatures and minimizing the heat sink size. The aim is to remove risks on the 3D converter components placement and ensure their effective integration before carrying out the first physical prototype. This approach is based on coupling an optimization environment with a thermal finite element simulation tool. A pre-sizing step using analytical models is performed to set the optimization computations coupled to numerical simulation.
Schnekenburger, Michael,Goffin, Eric,Lee, Jin-Young,Jang, Jun Young,Mazumder, Aloran,Ji, Seungwon,Rogister, Bernard,Bouider, Nafila,Lefranc, Florence,Miklos, Walter,Mathieu, Vé,ronique,de Tullio American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.11
<P>A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. On the basis of computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea] which displays a potent anti.proliferative activity on various glioma cell types, assessed by quantitative videomicroscopy, eventually triggering senescence. The impact on normal glial cells was lower with a selectivity index of >10. Furthermore, human U373 and Hs683 glioblastoma cell lines served to demonstrate the inhibitory activity of 18 against histone deacetylase (HDAC) class III sirtuins 1 and 2 (SIRT1/2) by quantifying acetylation levels of histone and non-histone proteins. The translational potential of 18 was validated by an NCI-60 cell line screen and validation of growth inhibition of drug resistant cancer cell models. Eventually, the anticancer potential of 18 was validated- in 3D glioblastoma spheroids and in vivo by zebrafish xenografts. In summary, compound 18 is the first representative of a new class of SIRT inhibitors opening new perspectives in the medicinal chemistry of HDAC inhibitors.</P>