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1
THE LONGEVITY OF CIRCUMSTELLAR DISKS: THE η CHAMAELEONTIS CLUSTER

LYO A-RAN,LAWSON W. A. The Korean Astronomical Society 2005 Journal of The Korean Astronomical Society Vol.38 No.2
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  ScienceON
  
  코리아스칼라
We have analysed near-infrared JHKL observations of the members of the $\approx$9 Myr-old $\eta$ Chamaeleontis cluster. Using (J - H)/(K - L) and (H - K)/(K - L) IR colour-colour diagrams for the brightest 15 members of the cluster, we find the fraction of stellar systems with near-IR excess emission was 0.60 $\pm$ 0.13 (2$\sigma$). For the CTT and WTT star population, we also find a strong correlation between the IR excess and Ha emission which is also known as an accretion indicator. The (K - L) excess of these stars appears to indicate a wide range of star-disk activity; from a CTT star with high levels of accretion, to CTT - WTT transitional objects with evidence for some on-going accretion, and WTT stars with weak or absent IR excesses. Among the brightest 15 members, four stars (RECX 5, 9, 11 and ECHA J0843.3-7905) with IR excesses ${\Delta}$(K - L) > 0.4 mag and strong or variable optical emission were identified as likely experiencing on-going mass accretion from their circumstellar disks which we confirmed their accretion disks from the optical high-resolution echelle spectroscopic study. The result-ing accretion fraction of 0.27 $\pm$ 0.13 (2$\sigma$) suggests that the accretion phase, in addition to the disks themselves, can endure for at least ${\~}$10 Myr.
2
Mutations in SLC26A1 Cause Nephrolithiasis

Gee, H.Y.,Jun, I.,Braun, D.A.,Lawson, J.A.,Halbritter, J.,Shril, S.,Nelson, C.P.,Tan, W.,Stein, D.,Wassner, A.J.,Ferguson, M.A.,Gucev, Z.,Sayer, J.A.,Milosevic, D.,Baum, M.,Tasic, V.,Lee, M.G.,Hildebr University of Chicago Press [etc.] 2016 American journal of human genetics Vol.98 No.6
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<P>Nephrolithiasis, a condition in which urinary supersaturation leads to stone formation in the urinary system, affects about 5%-10% of individuals worldwide at some point in their lifetime and results in significant medical costs and morbidity. To date, mutations in more than 30 genes have been described as being associated with nephrolithiasis, and these mutations explain about 15% of kidney stone cases, suggesting that additional nephrolithiasis-associated genes remain to be discovered. To identify additional genes whose mutations are linked to nephrolithiasis, we performed targeted next-generation sequencing of 18 hypothesized candidate genes in 348 unrelated individuals with kidney stones. We detected biallelic mutations in SLC26A1 (solute carrier family 26 member 1) in two unrelated individuals with calcium oxalate kidney stones. We show by immunofluorescence, immunoblotting, and glycosylation analysis that the variant protein mimicking p.Thr185Met has defects in protein folding or trafficking. In addition, by measuring anion exchange activity of SLC26A1, we demonstrate that all the identified mutations in SLC26A1 result in decreased transporter activity. Our data identify SLC26A1 mutations as causing a recessive Mendelian form of nephrolithiasis.</P>