정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

간호학과 학생들의 노인에 대한 지식 및 태도

양경미,오현이,김진선,백영주 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Objectives: The purposes of this study were to investigate nursing students' knowledge and attitudes toward the elderly, to examine the correlation between knowledge and attitudes, and to identify predictors of nursing students' attitudes toward the elderly. Method: Study participants were 195 nursing students who enrolled in a university located in Gwangju. Data were collected using structured questionnaires. Results: The average FAQ Ⅰ score for nursing students in this study was 50.2%. The level of nursing students' knowledge was relatively low compared to knowledge of Western nursing students in previous studies. Moreover, the average scores of psychological dimension and family/sociological dimension were lower than those of physical/physiological dimension. Negative biases were prevalent when the biased scores were computed. Nursing students also reported a little preference for working with older patients after graduation. Although the average attitude score was in a neutral range, the number of items in a negative attitude score range were more than those in a positive attitude score range. Contrary to expectation, the correlation between knowledge and attitude was not statistically significant. Nursing students who have clinical experiences with the elderly reported higher scores on FAQ Ⅰ than their counterparts. A current relationship with elderly living in their household was a significant predictor of nursing students' attitudes toward the elderly. Conclusion: Results from this study suggest that nursing education should be directed to increase the nursing students' knowledge and positive attitudes toward the elderly. Exposure to well elderly as clients before they are hospitalized or institutionalized may be helpful to increase nursing students' positive attitudes toward the elderly.

흰쥐에서 절식과 고지방식이가 콜레스테롤 및 지방대사에 미치는 영향

양정례,박경아,진현화,김양하 창원대학교 생활과학연구소 2001 생활과학연구 Vol.5 No.-

This study was performed to investigate the effects of diet pattern on lipid and cholesterol metabolism in rats. Sprague-Dawley rats were fed four types of diets for four weeks, respectively: a control diet, 40% energy restriction diet, high animal fat diet or high plant fat diet. Control and 40% energy restriction diets were composed by AIN-76 diet and high fat diets were composed by 53.6% of animal or plant fat. In rats fed with 40% energy restriction diet showed significantly low body weight gain, liver, abdominal and subcutaneous adipose tissue weights compared to rats fed with control diet. In rats fed with high animal fat diet showed significantly high body weight gain, liver, abdominal and subcutaneous adipose tissue weights compared to rats fed with control diet. In rats fed with high plant fat diet showed similar body weight gain. The increase of adipose tissue weight was much smaller in rats fed with high plant compared to rats fed with high animal fat diet implying the effect of high fat diet on fat accumulation on adipose tissue may defend on the kinds of fats. Plasma total cholesterol and triglyceride concentrations were significantly decreased in rats fed high plant fat diet. However, liver total cholesterol and triglyceride concentrations were signigficantly increased in rats fed high animal fat diet. The fibrinolytic activity of serum was significantly increased in rats fed high plant fat diet compared to rats fed with control diet.

한강변 응급센터에 내원한 익수환자에 대한 임상적 고찰

양진홍,박규남,최승필,김영민,김세경 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: There are approximately 2,400 drowning deaths reported every year in Korea, but there are few good reports about submerged patients visiting the emergency room, so this study was designed to investigate the clinical characteristics and outcomes of submerged patients treated at an emergency medical center near the Han river. Methods: A retrospective review of 123 cases of submerged patients admitted to our emergency medical center over a 5 year period from 1996 to 2000 was conducted. Results: Among the 123 submerged patients, there were 66 males and 57 females, and their mean age was 33.18. The common cause of submersions was a suicide attempt, followed by lack of attention, unknown etiology, and water sports such as swimming. Most of the patients were transported to ER by 119 ambulance. In-hospital CPR was performed on 27(22%) cases. At initial ECG rhythm of these cases, asystole was noted if 25 patients; VF and pulseless electrical activity, respectively, were noted in two others. Prehospital CPR had been performed on all in-hospital CPR cases except 2. Prolonged ROSC after succesful CPR was noted in 13 cases, The mean duration of CPR was 26 minutes. Five patients survived after CPR. Their neurologic outcomes were assessed on CPC(cerebral performance category). Three patients were categorized in CPC1, the other two patients were categorized in CPC3 and CPC4. Conclusion: Submerged patient's visits to emergency medical center near the Han river were most frequent in summer for suicide purposes. Drowned patients were more hypothermic than other cardiac arrest cases, and resulted in better outcome even with prolonged arrest time, if they were given appropriate prehospital CPR and aggreissive in-hospital resuscitation.

위탁급식전문업체 인증제도 도입을 위한 급식운영 평가 모형 기준항목 선정

양일선,박문경,차진아,이경태,박상용 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.3

The foodservice industry is changing more and more from on-site foodservice management to contract foodservice management. However there are differences according to the level of management and operation of contract foodservice management company (CFMC), The necessity of certification on CFMC is increasing to enable fair discrimination of CFMC among most clients that want to contract with CFMC. This study was performed to identify the foodservice operation evaluation model's criteria items for certifying CFMC. The analysis research methods included literature review, content analysis, individual interview, Delphi technique, and brain storming. First, the following infrastructure items were prepared in the contractor's viewpoint: procurement, transparency of operation, menu development and operation system, nutrition service system, professional employee education, sanitation and safety management system, customer satisfaction system, facility system, management information system (MIS), business and economics. Second, the evaluation criteria required by the contractor on the client's view point was similar to school foodservice, hospitalfoodservice, and business andindustry foodservice except extraordinary items of field. Third, evaluation criteria and detail categories and items were identified such as financial focus, customer focus, process focus, human focus, and renewal and development by grafting on intellectual capital evaluation methodology for CFMC.

건축작품을 응용한 구두, 핸드백 디자인 연구 : 라파엘 비뇰리(Rafael Vin`oly)의 건축작품을 중심으로 Focusing on Works of Rafael Vin`oly

양취경,김진형 誠信女子大學校 生活文化硏究所 2003 生活文化硏究 Vol.17 No.-

Fashion and architecture are the practical figurative arts of people that have been reflecting the spiritual and phenomenal aspects from the past to modern times, which are the expressions of artistic recognition. The elements of architecture that have limitless possibilities for figurative characteristics provide artists with numerous motives and may well provoke infinite inspiration in the forms and details as the source of ideas. Also, in modern fashion that is represented by individuality and diversity, the formative elements of architecture may act as a stimulating elements that may bring change and accent. Cosequently, in this study, we tried to give shape to the figurative/symbolic aspects of architeture through images and then to use them as the inspirational motive for our works. The objective of our study lies in expanding the expressive range of design though shoes and handbag production that utilizes architectural works. Our study considered the origin, history and types of shoes and handbags for model production and looked through the figurative aspects of architecture shown in fashion from the past until modern times. To consider the architectural arts of Rafael Vin~oly, which is the objective of our ideas in our study, we analyzed his cultural background and the figurative characteristics of his architectural works by their shapes, decorative elements, textile materials, and colors. Based on such a theoretical background, we restructured the figurative image of architecture of 16 model works and then we designed and produced them. In the course of design, to express the images of architecture, we used expressional methods such as padding, stitching, tucks, patchwork, etc. and pursued decorative effects. As for materials, we used bovine leather, sheepskin, snakeskin, the skins of unborn calves, and printed leather. We also used Crystal Hot Fix, and Rhine Stone to design the products that focused on their utility. The following are our conclusions reached through design and production of shoes and handbags based of Rafael Vin~oly's architectural works as our inspiration. First, architecture as a practical formative art consisted of decorative shape elements, materials, and colors in their formative aspects. Further, the architecture expressed artistic/aesthetic concepts in their content. It is an area of limitless artistic inspiration. Second, the architectural works of Rafael vin~oly focused on connectivity. We, therefore, drew our suitable architectural work in concern for the given situation and "realization of publicity". They have a high-degree of detailed expression through the use of exaggerated materials and combined wonderful structural creativity, thus creating excellent figurative beauty. Third, by using the figurative elements of architecture as the basic "material" in designing shoes and handbags, we found that the shapes, decorative details and the figurative aspects of the architecture could be the inspiration for design production. Fourth, the expressional methods such as padding, stitching, tucks, and patchwork used in model work production were quite suitable for expressing the figurative images. The materials and decorations such as bovine leather, sheepskin, snakeskin, the skins of unborn calves, and printed leather and, Crystal Hot Fix and Rhine Stone clearly brought out the formative images in shoes and handbags. Thus, we concluded that the expression of the formative elements of architecture will improve practicality and artistic expression and wil enable design development to transcend the existing uniformity, thus helping to create new active ideas.

실증연구를 위한 주택용 태양열 온수기 모니터링 시스템 개발

양동조,김재열,한재호,송경석,김우진 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The application of solar energy, in the field of alternative energy, was on the increase tendency. In the case of advanced nations, through continuous R&D, solar hot water heater with high efficiency has been used for the house and the industrial process on business, advanced nations were reached up the experimental stage of solar generation system. But, the actual circumstance of the domestic has been not accomplished the popularization of solar hot water heater and the settlement of it which is the fundamental stage of the solar energy usage. This trouble, the domestic was flooded with small enterprise for producing solar hot water heater, was caused by the popularization and the production without verification of performance. To supply the monitoring program for evaluating solar hot water heater, this research was purpose to improve the technical development of the enterprise for producing solar-heat hot-water-boiler and served as an aid for the enlargement and the popularization on solar energy.

음향방출을 이용한 저어널 베어링의 조기파손감지(Ⅱ) : Part Ⅱ : Intervention of Foreign Particles in Lubrication 윤활유 이물질 혼입의 영향 및 감시

권오양,윤동진,김경웅,정민화 韓國非破壞檢査學會 1994 한국비파괴검사학회지 Vol.14 No.2

일반적으로 회전기기의 저어널 베어링 부분은 윤활유 공급의 부족이나 윤활층에 이물질이 혼입되면 시스템의 고장이나 가동중단 등의 원인이 되기도 한다. 따라서 베어링 손상에 기인하는 사고와 관련된 안전운전 문제와 유지비용의 절감을 위해 여러가지 파괴 및 비파괴시험법들이 사용되어 왔다. 본 연구에서는 저어널 베어링에서 가장 발생하기 쉬운 윤활층에의 이물질이 혼입에 의해 야기되는 베어링 파손의 조기검출을 위해 음향방출 기술을 적용하였으며, 전보의 연구에 이어 좀더 정량적이고 체계적인 실험을 수행하였다. 실험실용으로 직접 제작한 모의베어링 시스템을 이용하여 여러 형태의 인위적인 이물질 흔입 상태를 만들어 실험하였으며 베어링 손상 및 결함 형태의 해석을 위해 AE rms level, 파형분석, AE 변수 등의 여러 파라메터를 사용하여 분석 고찰하였다. 그 결과 AE rms level의 변화가 이물질 흔입의 영향에 민감함을 보여주었으며 AE변수등 다른 정보들로부터 손상 원일별로 신호형태를 확인할 수 있었다. Journal bearings in the rotating machineries are vulnerable to the contamination or the insufficient supply of lubricating oil, which is likely to be the cause of unexpected shutdown or malfunction of these systems. Various destructive and nondestructive testing methods had been used for the reduction of maintenance cost and the operational safety problems due to the accidents related to bearing damages. In this experimental approach, acoustic emission monitoring in employed to the detection of incipient failure caused by intervention of foreign particles most probable in the journal bearing systems. Experimental schedules for the intervention of foreign particles was composed to be more quantitative and systematic than last study in consideration of minimum oil film thickness and particle size . The experiment was conducted under such designed conditions as inserting alumina particles to the lubrication layer in the simulated journal bearing system. Several parameters such as AE rms level, waveform, AE energy distribution and other AE event parameter are used for analysis and characterization of damage source. The results showed that the history of damage was well correlated with the changes of AE rms level and the types of damage source signal can be verified using other informations such an waveform, distribution of AE parameter etc.

I-Beam연속교 내측지점의 소성변형에 관한 연구

정경희,김진성,양승이 한국산업안전학회 2002 한국안전학회지 Vol.17 No.4

The steel shows plastic deformation after the yield point exceeds. Because of overloads, the plastic deformation occurs at the interior support of a continuous bridge. The plastic deformation is concentrated at the interior support, and the permanence deformation at the interior support remains after loads pass. Because local yielding causes the positive moment at the interior support, it is called "auto moment". Auto moment redistributes the elastic moment. Because of redistribution, auto moment decreases the negative moment at the interior support of a continuous bridge. In this paper, the moment-rotation curve from Schalling is used. The plastic rotation is computed by using Beam-line method, and auto moment is calculated based on the experiment curve. The design example is presented using limit state criterion.

정상 성인에 경구 투여한 Cefixime 두 정제의 생물학적 동등성 비교

강진양,서성훈,이경태,문창훈,강진한,이동건,최정현,신완식 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4

목적 : 식품의약안전청 고시 제 1998-86호(1998. 8.26) "생물학적 동등성 시험 기준"에 의하여 섹심 캅셀(시험약, 한국유나이트제약)과 슈프락스 캅셀(대조약, 동아제약)의 생물학적 동등성을 비교 검토하였다. 방법 : 2×2 라틴 방격법에 따라 건강한 성인 남성 지원자 20명에게 cefixime 100㎎씩 경구투여하였다. 약제투여 후 12시간까지 일정간격으로 채혈하였고 각 피험자들의 혈중약물농도 데이터로부터 구한 Area under the concentration (AUC), C_(max), T_(max) 등의 생체이용률 파라미터에 대해 통계학적으로 고찰하여 두 제제간의 생물학적 동등성을 평가하였다. 결과 : AUC, C_(max), T_(max)에 대한 평균값의 차가 각각 1.26%, 3.73%, 6.21%로서 모두 대조약의 20% 이내에 들어 생물학적 동등성 판정기준의 전제조건을 만족하였다. 분산분석 결과 AUC, C_(max), T_(max)의 각 비교 항목에 있어서 모두 유의수준 α=0.05의 군/순서효과 검정에서 F비가 F 분석표의 한계값보다 작아 교차시험이 제대로 이루어졌음을 확인할 수 있었으며, AUC, C_(max), T_(max) 각 비교항목에 있어서 유의수준 α=0.05에서 대조약에 대한 최소검출차(Δ)가 각각 17.74%, 17.05%, 15.67%로 모두 20% 이내이었으며, 검출력(1-β)도 모두 0.8 이상으로 나타나 생물학적 동등성 판정기준을 만족시켰다. 또 AUC, C_(max), T_(max) 각 비교항목에 있어서 대조약에 대한 생체이용률 차이의 신뢰한계(δ)가 ±20% 이내이어야 한다는 생물학적 동등성 판정기준을 모두 만족시켰다. 결론 : 이상의 실험결과로 시험약은 대조약에 대하여 생물학적 동등성 평가항목인 AUC, C_(max), T_(max)에서 모두 판정기준을 만족시켜 시험약은 대조약과 생물학적으로 동등하다고 사료된다. Background : The study was designed to compare the bioeqivalence between the test (CEXIME®. United Korea. Co., Ltd) and control (SUPRAX®. Dong-a Pharm. Co.. Ltd) capsules of cefixime. Methods : Twenty. healthy, male volunteers completed the study Each subject ingested single dose (100 ㎍) of the control and test drugs in 2?2 crossover design with a week drug-free interval between the doses. Blood samples were collected serially up to 12 hours and plasma concentrations of cefixime were measured by high-performance liquid chromatography with UV detection. A non-compartmental approach was used for analysis of the concentration-time data. Results : The area under the curve (AUC), the maximum concentration of drug (C_(max)). and time to reach C_(max)(T_(max)) did not show any significant difference between the two preparations by ANOVA. The mean differences of AUC, C_(max), and T_(max) were within 20% of the control drug, those were 1.26%. 3.73%. and 6.21%. respectively. The confidence limits of three parameters were satisfied the bioeqivalence criteria. Conclusion : These results suggest that the test drug was bioequivalent with the control drug.