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중대산업사고 예방을 위한 종합위험관리체제(IRMS) 구축에 관한 연구
권혁면,성대현,김재현,임대식,김기영,편무욱,문일,고재욱,이영순,윤인섭 한국안전학회 2003 한국안전학회지 Vol.18 No.3
The Process Safety Management (PSM) by the Law of Industry, Safety and Health has been performed for preventing major accidents of chemical plants since 1996. In terms of preventing chemical accidents more precisely, it is essential to develop a tool for quantitative risk assessment. For this, KOSHA (Korea Occupational Safety and Health Agency) developed an Integrated Risk Management System (IRMS) . The system is designed to assimilate data on chemical plant hazards from external database, to integrate these data with location information (topographic and demographic), and to make them user-friendly accessible. The system consists of several main functions: display of five major Korean petrochemical complex layout, display of equipment layout with its information utilizing the external database, zonation of the hazard effected area with consequence analyses, the most probable accident scenario generation, accident/incident database and calculation of frequency of accident using equipment reliability database, etc. The highlight of IRMS is to provide the risk contours using GIS(Geographical Information System) technology. IRMS is intended to manage hazardous installation more systematically and effectively, to reduce the number of accident remarkably, further minimizing production loss in the plant. The system is now under application to about 500 PSM sites as well as and emergency authorities in Korea by KOSHA (Korea Occupational Safety and Health Agency)
Jae Myun Ryu,Im Kwon Seo,Tae Myoung Kim,Yun-Bae Kim,Sung Kwon Moon,Kyung-Hwan Jung,Keerang Park,Seung Bok Hong,Seock-Yeon Hwang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.2
The chemopreventive effects of Magnolia ovobata water extract (MWE) and 70% ethanol extract (MEE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) were investigated. Six-week-old male F344 rats were divided to 7 experimental groups; 1) DMH alone, 2) DMH+0.3% MWE, 3) DMH+1% MWE, 4) DMH+3% MWE, 5) DMH+1% MEE, 6) 3% MWE alone and 7) normal control. Animals were subcutaneously injected with DMH (30 mg/kg) 4 times to induce colonic ACF during the initial 2 weeks, and fed with a basal containing various concentrations of test materials (MWE or MEE) for 8 weeks including the DMH-treatment period. The formation of ACF on colonic mucosa was observed after staining with methylene blue. There are no specific effects of MWE and MEE on body weight, feed and water consumptions, organ weights, histopathological observations, and hematological and blood chemistry analyses. Challenge with DMH alone induced mean number of 270.1 ACF/colon which was somewhat inhibited by MWE treatment, showing average numbers of 234.3-242.1 ACF/colon. In comparison, the ACF number was significantly suppressed to 216.5 by administration of 1% MEE. Therefore, these results suggest that Magnolia ovobata extracts, especially MEE, exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the early development of ACF.
Advanced Korean Industrial Safety and Health Policy with Risk Assessment
Kwon, Hyuck-Myun,Cho, Jae-Hyun,Moon, Il,Choi, Jae-Wook,Park, Doo-Yong,Lee, Young-Soon Occupational Safety and Health Research Institute 2010 Safety and health at work Vol.1 No.1
This article describes a systematic roadmap master plan for advanced industrial safety and health policy in Korea, with an emphasis on. Since Korean industries had first emergence of industrial safety and health policy in 1953, enormous efforts have been made on upgrading the relevant laws in order to reflect real situation of industrial work environment in accordance with rapid changes of Korean and global business over three decades. Nevertheless, current policy has major defects; too much techniques-based articles, diverged contents in less organization, combined enforcement and punishments and finally enforcing regulations full of commands and control. These deficiencies have make it difficult to accommodate changes of social, industrial and employment environment in customized fashion. The approach to the solution must be generic at the level of paradigm-shift rather than local modifications and enhancement. The basic idea is to establish a new system integrated with a risk assessment scheme, which encourages employers to apply to their work environment under comprehensive responsibility. The risk assessment scheme is designed to enable to inspect employers' compliances afterwards. A project comprises four yearly phases based on applying zones; initially designating and operating a specified risk zone, gradually expanding the special zones during a period of 3 years (2010-2012) and the final zone expanded to entire nation. In each phase, the intermediate version of the system is updated through a process of precise and unbiased validation in terms of its operability, feasibility and sustainability with building relevant infrastructures as needed.
Comparative Effectiveness of Distilled Water and Isotonic Saline in a Rat Model of Dry Eye
Tae Myoung Kim, Jae Myun Ryu, Im Kwon Seo, Dongsun Park, Sun Hee Lee, Dae-Kwon Bae, Goeun Yang, Yun-Hui Yang, Tae Kyun Kim, Ehn-Kyoung Choi, Seock-Yeon Hwang, Yun-Bae Kim 충북대학교 동물의학연구소 2010 Journal of Biomedical and Translational Research Vol.11 No.4
본문참고
Kwon, Hyun-Jung,Kim, Tae-Myoung,Ryu, Jae-Myun,Son, Seung-Hwan,Hong, Jin-Tae,Jeong, Heon-Sang,Kang, Jin-Seok,Ahn, Ji-Yun,Kim, Sung-Ran,Ha, Tae-Youl,Kim, Dae-Joong The Korean Society of Food Science and Nutrition 2008 Preventive Nutrition and Food Science Vol.13 No.3
Cancer-preventive effects of ethanol extract of elm tree root (EEE) were investigated. In the in vitro cytotoxicity assay, colon cancer cells were incubated with a chloroform fraction of EEE (CF-EEE). CF-EEE significantly inhibited the proliferation of cells and induced apoptotic cell death in a dose-dependent manner. For the assessment of chemopreventive efficacy in vivo, male F344 rats were fed with EEE (0.5 or 1%) in diet for 8 weeks, and were subcutaneously injected with 1,2-dimethylhydrazine (DMH) to induce colonic aberrant crypt foci (ACF). EEE (0.5 and 1%) significantly decreased both the numbers of AC (1191.1/colon) and ACF (529.3/colon) induced by DMH. In addition, in the Western blot analysis on the colonic mucosa, administration of EEE triggered expression of caspase-3, a key factor of an apoptotic cascade. These results suggest that extract of elm tree root may have potential chemopreventive principles that lead to apoptosis of cancer cells, and thereby suppress colorectal carcinogenesis during the initiation stage.
Skin Irritation and Sensitization Studies on Rosin<SUP>®</SUP> Powder
Jae Myun Ryu,Im Kwon Seo,Tae Myoung Kim,Yun-Bae Kim,Si-Kwan Kim,Seung Bok Hong,Seock-Yeon Hwang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.2
Primary skin irritation and skin sensitization induced by Rosin<SUP>®</SUP>, an extract of pine tree, were assessed in rabbits and guinea pigs, respectively, according to the guidelines of Korea Food and Drug Administration. In primary skin irritation test, 5% and 10% of Rosin<SUP>®</SUP> (in 80% ethanol) exhibited mean score 1.17 and 1.33, respectively, leading to primary irritation indices (PII) of 0.29 and 0.33. Thus, the test compound Rosin<SUP>®</SUP> was evaluated to be a ‘non-irritant’ material. In skin sensitization study using guinea pig maximization test (GPMT), 5% and 10% Rosin<SUP>®</SUP> did not induce erythema or edema, displaying sensitization score 0 and rate 0%, whereas 0.1% 2,4-dinitrochrolobenzene (DNCB), a positive control, induced sensitization scores 1-2 and rate 80%. Therefore, Rosin<SUP>®</SUP> and DNCB were classified to grade Ⅰ and Ⅳ, indicating weak and strong sensitizers, respectively. Taken together, it is suggested that Rosin<SUP>®</SUP> is a pratically-safe material to skin without potential of irritation or allergic sensitization.
Jae-Kyung Kwon,Dong-Joo Choi,Haijie Yang,Dong Wan Ko,Ilo Jou,Sang Myun Park,Eun-Hye Joe 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.6
Astrocytes are activated in response to brain damage. Here, we found that expression of Kir4.1, a major potassium channel in astrocytes, is increased in activated astrocytes in the injured brain together with upregulation of the neural stem cell markers, Sox2 and Nestin. Expression of Kir4.1 was also increased together with that of Nestin and Sox2 in neurospheres formed from dissociated P7 mouse brains. Using the Kir4.1 blocker BaCl2 to determine whether Kir4.1 is involved in acquisition of stemness, we found that inhibition of Kir4.1 activity caused a concentration-dependent increase in sphere size and Sox2 levels, but had little effect on Nestin levels. Moreover, induction of differentiation of cultured neural stem cells by withdrawing epidermal growth factor and fibroblast growth factor from the culture medium caused a sharp initial increase in Kir4.1 expression followed by a decrease, whereas Sox2 and Nestin levels continuously decreased. Inhibition of Kir4.1 had no effect on expression levels of Sox2 or Nestin, or the astrocyte and neuron markers glial fibrillary acidic protein and β-tubulin III, respectively. Taken together, these results indicate that Kir4.1 may control gain of stemness but not differentiation of stem cells.
Effect of Repeated Administration of Silk Peptide on the Immune System of Rats
Jae Myun Ryu,Tae Myoung Kim,Im Kwon Seo,Seongho Yeon,Woo-Taek Lim,Jeong-Yong Lee,Seock-Yeon Hwang,Namgil O,Jugyeong Song,Jinsoo Lee,Yun-Bae Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
In order to elucidate the possibility of influence on the immune system, silk peptide was administered to rats for 4 weeks. Male and female Sprague-Dawley rats were orally treated with low (500 ㎎/㎏) or high (2,000 ㎎/㎏) doses of silk peptide, and complete blood counts, organ weights, histopathology and cellularity of immune systems were examined. Silk peptide did not cause clinical signs, although the body weight gain at the high dose was slightly reduced. In hematological analysis, the number of white blood cells (WBC) and differential counts, the number of red blood cells (RBC) and RBC indices, and the number of platelets and mean platelet volume (MPV) were not affected by the administration of silk peptide. Especially, there were no differences in the number and rate (%) of immune cells such as lymphocytes as well as monocytes and granulocytes between vehicle and silk peptide-treated groups. Silk peptide neither affected the thymus and spleen weights, in addition to the cellularity in thymus, nor induced gross and microscopic lesions of thymus, spleen and lymph node. Taken together, 4-week administration of silk peptide up to 2,000 ㎎/㎏, the upper-limit dose in repeated-dose toxicity study, did not exhibit adverse effects on the immune systems, leading to no observed adverse effect level (NOAEL) higher than 2,000 ㎎/㎏. Without influence on the production, maturation and death process of immune cells at 20-fold dose of clinical dose (100 ㎎/㎏), silk peptide was evaluated to be a practically non-toxic material.