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Guzii, Alla G.,Makarieva, Tatyana N.,Denisenko, Vladimir A.,Dmitrenok, Pavel S.,Kuzmich, Aleksandra S.,Dyshlovoy, Sergey A.,von Amsberg, Gunhild,Krasokhin, Vladimir B.,Stonik, Valentin A. American Chemical Society 2016 ORGANIC LETTERS Vol.18 No.14
<P>Melonoside A (<B>1</B>), the first representative of a new class of ω-glycosylated fatty acid amides, was isolated from the Far Eastern marine sponge <I>Melonanchora kobjakovae</I>. The structure of <B>1</B>, including absolute configuration, was established using detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound <B>1</B> induces autophagy of human cisplatin-resistant germinal tumor cells NCCIT-R.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2016/orlef7.2016.18.issue-14/acs.orglett.6b01678/production/images/medium/ol-2016-01678y_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol6b01678'>ACS Electronic Supporting Info</A></P>