미세침윤 자궁경암의 세포진

이윤성(YS Lee),구본수(BS Koo),정성희(SH Chung),박종근(JK Park),이승호(SH Lee),이태호(TH Lee) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.5

자궁경질부 원추절제에서 확진된 36예의 미세침윤경암의 세포진 소견을 검토한 바 그 성적을 아래와 같이 요약할 수 있었다. 미세침윤경암의 핵염색질은 coarse pattern이 61.6%,fine pattern이 38.9%이었다. 세포다형성은 경도가 58.3%, 중등도가 16.7%, 고도가 25.0%이었다. 악성세포의 군집성은 경도가 38.9%, 중등도가 16.7%, 고도가 44.4%이었다. 세포진 배경은 clear가 61%로 가장 많았고 이하 출혈이 33.3%, 염증이 19.4%, necrotic debnis가 8.3%의 순이었다. 각 예별 최다악성세포출현 빈도는 large cell nonke-ratinizing type 이 16예로 44.4%로 가장 많았고, 이하keratinizing cancer cell type의 25.0%, clustered iso-diametric cancer cell type의 13.9%, fiber cell의 8.3%, small cancer cell의 2.8%, undifferentiated can-cer cell의 2.8%, parabasal dyskaryotic cell의 순이었다. 상기한 세포상의 특징 등으로 조직 진단을 추정하였을 때 그 성적은 dysplasia가 1예로 2.8%, CIS가 10예로 27.8%, microinvasive가 16예로 44.4%, invasive가 9예로 25.0%이었다. Studies were made on cytologic pictures in 36 cases of microinvasive ca. of ute- rine cervⅸ which were diagnosed by cone biopsy. The results summerized were as follows: There was 61.6% of coarse chromatin pattern and 38.9% of fine chromatin pattern. Regarding to the pleomorphism distribution of degree of slight, moderate and extensive were 58.3%, 16.7% and 25.0% respectively. Degree of aggregation in malignant Cells, slight, moderate and extensⅳe was 38.9%, 16.7% and 44.4% respectively, Cytologic back ground in smears from microinvasive ca. of uterine cerⅵx, the most frequently encountered was clear pattern, which revealed 61.0% and in order of bleeding pattern 33.3%, infection pattern 19.4% and necrotic debris pattern 8.3%. The distribution of predominant malignant cell type in each of 36 cases was large cell keratinizing type showed 44.4% and in order of keratinizing ca. cell type 25.0%, clustered isodiametric cell type 13.9%, fiber cell type 8.3% and small ca. cell type, undifferentiated and parabasal dyskaryotic cell type 2.8% each respectively. . When diagnosis was predicted with histologically proved microinvasive ca. of uterine cerⅵx through the characteristics of cytology pattern, dysplasia, ClS, mic- .roinvasⅳe and invasive ca. was 2.8%, 27.8%, 44.4% and 25.0% respectⅳely.

양막중 Lipid 함량에 관하여

이영순(YS Lee),구병삼(BS Koo),이지재(GJ Lee) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.5

This study was to evaluate the value of lipids in amniotic membranes of Korean women at term of pregnancy. The mean value of total lipids of ammiotic membranes was 8.32% in 52 samples. Phospholipid, total cholesterol and free cholesterol among total lipids showed 30.5%, 9.8% and 5.1%, respectively. Water content of amniotic membranes was 10.6%. Mean value of lipid in venous blood was 656mg% in 25 deliveried women.

복강내체액의 단백 및 전해질 함량에 관한 연구

최영송(YS Choi),최영열(YY Choe),차종욱(CU Cha),구병삼(BS Koo) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.8

The author attempted to observe the contents of electrolytes and protein in the human peritoneal fluid from June, 1975 to May, 1976 at out patient clinic in Dept. of OB & GY. The samples of peritoneal fluid was routinely aspirated from all patients undergoing laparoscopy for diagnostic purposes or in relation with voluntary tubal sterilization. The peritoneal fluid were obtained without difficulties in most of cases of laparoscopic procedure. Various electrolyte and protein contents were measured as follows. Flame-photometry(EEL Model 150) was used for determination of sodium and potassium levels, Schales & schales method for chloride content, EDTA method for calcium content, Atomic absorption spectro-photometer for magnesium content, and cellulose acetate electrophoresis for protein fraction of the peritoneal fluid and serum. The serum of all patients is used for comparison. The results obtained are summerized as follows: 1) The peritoneal fluid aspirated through the laparoscopic instrument attached syringe. More than 3 ml of peritoneal fluid was obtained in 60 cases(18.1%) of total 331 cases of examinations. 2) The normal amounts of peritoneal fluid varies from less than 1 to 45 ml. 3) The electrolytes of peritoneal fluid were compared to that serum. Calcium, chloride, sodium, and magnesium content in the peritoneal fluid were lower than that serum, but potassium content in the peritoneal fluid was higher than that serum. 4) The electrolyte contents of peritoneal fluid were compared with proliferative and secretory phase of menstrual cycle. In secretory phase, sodium, chloride, potassium, and magnesium contents were slightly higher than that proliferative phase, but calcium content was slightly lower than that proliferative phase. 5) The total protein content was 42 gm/liter for peritoneal fluid and 65 gm/liter for serum. 6) Electrophoretic studies showed the presence in peritoneal fluid of all normal constituents of serum. The results of the quantitative measurments of the different bands in a recording elec

류마티스 관절염 환자에서의 흉부 고해상 CT 소견

최요원,구자홍,박동우,박충기,이철범,이태희,양석철,이인홍,박용욱,김용수 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

To describe the high-resolution CT (HRCT) findings of the lung in patients with rheumatoid arthritis(RA). We retrospectively reviewed high-resolution CT scans of 38 patients who complained of dyspnea(n=9) and who had abnormalities on chest radiography (n=29) including 2 patients with Caplan's syndrome among 2436 patients of whom fulfilled the revised criteria of american rheumatism association for RA. Open lung biopsy was done in 3 patients. Among the totoal of 2436 patients with RA, abnormal findings were found in 29 patients (1.2%) on chest radiography and in 35 patients (1.4%) on chest HRCT. The HRCT scans showing the following abnormalities : ground-glass opacity (60.5%), thickening of interlobular septae (55.3%), intralobular lines (55.3%), small nodules (44.7%). honeycombing (42.1%), emphysema (31.6%), bronchiectasis(28.9%), mediastinal lymphadenopathy(26.3%), bronchiolitis obliterans (15.8%), pleural thickening (15.8%), consolidation (15.8%), pericardial effusion (5.3%) and pericardial thickening (5.3%). In patients with rheumatoid arthritis, HRCT scans of the lung commonly show areas of ground-glass opacity, thickening of interlobular septae, intralobular lines, small nodules, honeycombing, emphysema, bronchiectasis. And the presence and the extent of the lung lesions could recognize in detail by using HRCT.

단경쌍각자궁임신의 자연파열1예

김선행(SH Kim),최영송(YS Choi),신재승(JS Shin),구병삼(BS Koo) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.5

A case of spontaneous uterine rupture of bicornuate uterus in 27 weeks of pregnancy is presented with a brief review of literatures concerning congenital uterine anomalies.

Hepatocellular carcinoma in genetically obese mice

Kwon Hy,Won Ys,Koo Bc,Kim Ss,Lee Sb,Nam Kh,Kim Hc 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

상피성 난소암조직에서 면역조직화학법을 이용한 p53 유전자 관련단백의 발현에 관한 연구

김용민(YM Kim),민유선(YS Min),이찬(C Lee),염범우(BW Yeom),이규완(KW Lee),구병삼(BS Koo) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

The p53 protein is a 53-kDa nuclear phosphoprotein originally discovered in virus-transformed cells. It has a tumor suppressor function. Overexpression of mutant p53 protein is a common feature of invasive epithelial ovarian cancers. The aim of this study was to examine the potential role of mutated p53 protein in pvarian carcinogenesis and to evaluate its role as a prognostic marker. Immunohistachemical staining for p53 was performed in frozen samples of 39 common epithelial ovarian cancers. The obtained results are summarized as follows; 1. Overexpression of p53 was observed in 19/39(48.7%) epithelial ovarian cancers. 2. There was no correlation between p53 expression and age, histlogic type and tumor grade in epithelial ovarian cancer. 3. There was significant relationship between p53 expression and tumor stage. 4. There was significant relationship between p53 expression and 5-year survival rate. It is suggested that mutation of the p53 gene is associated with genesis and progression of ovarian cancer.

미만성 스텐트 내 재협착에 대한 Cutting Balloon 관동맥 성형술과 Holmium 풍선도자를 이용한 방사선 근접치료

강웅철,변영섭,최동훈,고영국,박성하,구본권,윤영원,장양수,이종두,심원흠,조승연 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.8

중증 난소 과자즉증후군 환자에서 발생한 뇌혈관 혈전색전증 1 례

심종욱(JW Shim),구자남(JN Koo),기숙현(SH Ki),서창석(CS Suh),김석현(SH Kim),문신용(SY Moon),이진용(JY Lee),장윤석(YS Chang) 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.9

Although there have been many advances in monitoring techniques, severe ovarian hyperstimulation syndrome(OHSS) still occur approximately in 1% of patients treated with ovulation induction agents in assisted reproductive technology(ART) program. the pathogenesis of OHSS is unclear, but the proposed mechanism is the production of vasoactive substances resulting in the increased local capillary permaeability and the fluid shift from the intravascular space into the third space . This fluid shift into the third space may cause ascites, hypovolemia, oliquria, hemoconcentration thromboembolism, and even death. Most cliniciated in thromboembolism in OHSS are the increased blood viscosity due to hemoconcentration, the alteration in coagualtion factors, the venous compression due to enlarged ova-ries and ascites, and the immobilization of patients. We have experienced a case of severe OHSS with a complications of cerebrovasular thromboemboslism in in vitro fetilization(IVF) patient and present it with the review of literatures.

Prostaglandin F2a 에 관한 중기임신중절

이수종(SJ Lee),구병삼(BS Koo),서용득(YD Suh),최영송(YS Choi) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.6

1976년 3월부터 1977년 2월까지 12개월간 고려대학교 의과대학 부속병원 산부인과에 의학적 및 기타 적응증으로 중기임신중절을 목적으로 입원한 28예에 대하여 prostaglandin F₂α의 간헐적 양막외 주입법을 시행하여 유산을 성공하였으며 그 결과를 조사분석하여 다음과 같은 결론을 얻었다. 1) Prostaglandin F₂α의 주입에서 부터 유산까지의 평균 소요시간은 18.89시간이 었다. 초산부에서는 평균 21.19시간, 경산부에서는 평균 17.41시간이 소요되었으며 경 산부에서 초산부보다 약간 빠른 것을 볼수 있었다. 2) Prostaglandin F₂α의 주입량은 최소 1,500㎍에서 최대 11,250㎍까지 였으며, 초산부에서는 평균 5036.36㎍, 경산부에서는 평균 4035.29㎍이 주입되었다. 3) 유산성공율은 24시간내에 85.7%의 성공율을 보여 주었고, 36시간내에 100%의 성공율을 보여 주었다. 4) 중기임신중절의 적응증중 정신사회적 문제가 16예로 가장 많았고, 자궁내태아사 망이 4예를 차지했다. 5) 부작용은 오심, 구토, 설사 등 소화기계통의 장애(14.3%)가 가장 많았고, 악한과 발열반응이 각각 1예 있었다. 6) 가장 흔한 합병증은 불완전유산(25%)이었고, 소파수술과 용수박리 등으로 태반 조직을 제거하였다. The use of prostaglandin F2α administered by extra-ovular infusion through foley catheter for the induction of abortion was studied in 28 patients between 16 and 28 weeks gestation. No serious complications occurred. Some minimal side effects were observed. Occasional vomiting was the commonest symptom but the incidence of side effects was lower than with alternative routes of administration. Side effects were in general well tolerated by the patients and never required therapy or termination. There were 4 cases of incomplete abortion with over 250ml, of estimated blood loss, but transfusion was not required. The method has proved a safe and effective means of terminatimg pregnancies in the second trimester. The results were obtained as follow; 1. The mean abortion time from infusion to the abortion of the fetus was 18.89 hours. The mean abortion time for the multiparas was 17.41 hours, somewhat lower than the mean time for the primiparas of 21.19 hours, but this difference was not statistically significant. 2. the mean total dosage of prostaglandin F2α was 5036.36 ug in primiparas and 4035.29 ug in multiparas. 3. The abortion was successfully induced in 85.7% of patients within 24 hours and in 100% within 36 hours. 4. The most common indication of mid-trimester abortion was psychological problem in 16 cases, next was intraurteine fetal death in 4 cases. 5. the most common side effects consisted of gastrointestinal sysptoms(14.3%) such as nausea, vomiting and diarrhea. Other side effects included transient pyrexia and chilling. 6. The most common disadvantage was incomplete abortion. In 75% of patients, abortion was complete but in 255 of patients was incomplete. These were managed by dilatation and evacuation or manual removal of the placenta.