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Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase
Wang, Zhihong,Kim, Min-Sik,Martinez-Ferrando, Isabel,Koleske, Anthony J.,Pandey, Akhilesh,Cole, Philip A. American Chemical Society 2018 Biochemistry Vol.57 No.8
<P>Identifying direct substrates targeted by protein kinases is important in understanding cellular physiology and intracellular signal transduction. Mass spectrometry-based quantitative proteomics provides a powerful tool for comprehensively characterizing the downstream substrates of protein kinases. This approach is efficiently applied to receptor kinases that can be precisely, directly, and rapidly activated by some agent, such as a growth factor. However, nonreceptor tyrosine kinase Abl lacks the experimental advantage of extracellular growth factors as immediate and direct stimuli. To circumvent this limitation, we combine a chemical rescue approach with quantitative phosphoproteomics to identify targets of Abl and their phosphorylation sites with enhanced temporal resolution. Both known and novel putative substrates are identified, presenting opportunities for studying unanticipated functions of Abl under physiological and pathological conditions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/2018/bichaw.2018.57.issue-8/acs.biochem.7b01158/production/images/medium/bi-2017-01158c_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bi7b01158'>ACS Electronic Supporting Info</A></P>
Nonradiative energy transfer between colloidal quantum dot-phosphors and nanopillar nitride LEDs.
Zhang, Fan,Liu, Jie,You, Guanjun,Zhang, Chunfeng,Mohney, Suzanne E,Park, Min Joo,Kwak, Joon Seop,Wang, Yongqiang,Koleske, Daniel D,Xu, Jian Optical Society of America 2012 Optics express Vol.20 No.2
<P>We present in this communication our study of the nonradiative energy transfer between colloidal quantum dot (QD) phosphors and nitride nanopillar light emitting diodes (LEDs). An epitaxial p-i-n InGaN/GaN multiple quantum-well (QW) heterostructure was patterned and dry-etched to form dense arrays of nanopillars using a novel etch mask consisting of self-assembled In3Sn clusters. Colloidal QD phosphors have been deposited into the gaps between the nanopillars, leading to sidewall coupling between the QDs and InGaN QW emitters. In this approach, close QW-QD contact and a low-resistance design of the LED contact layer were achieved simultaneously. Strong non-radiative energy transfer was observed from the InGaN QW to the colloidal QD phosphors, which led to a 263% enhancement in effective internal quantum efficiency for the QDs incorporated in the nanopillar LEDs, as compared to those deposited over planar LED structures. Time-resolved photoluminescence was used to characterize the energy transfer process between the QW and QDs. The measured rate of non-radiative QD-QW energy-transfer agrees well with the value calculated from the quantum efficiency data for the QDs in the nanopillar LED.</P>