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Jihae Nam,Jung Soo Kim,Hee Won Kim,Jeong Gu Kang,Jeong-Heon Ko 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
Early diagnosis and appropriate treatment can significantly lower the death rate from cancer, so the discovery of low-cost and high-efficiency cancer biomarkers for early diagnosis of cancer has been ongoing for a long time. However, most biomarkers based on quantitative differences are not limited to specific cancers and have inconsistent reproducibility, so they are used as an auxiliary form of diagnosis. Accordingly, we tried to discover biomarkers with improved diagnostic ability by considering not only quantitative differences but also qualitative differences, that is, changes in glycosylation. Protein X, which was confirmed to have a specific glycosylation structure in liver cancer patients through our previous study, was selected as a target protein, and its potential as a liver cancer biomarker was investigated through quantitative and qualitative analysis. In particular, to analyze the glycosylation pattern of protein X, an aglycosylated antibody-based lectin-coupled immunoassay was introduced and verified. As a result of analyzing the patient's clinical samples through this method, it was confirmed that the fucosylation pattern of protein X was similar to that of AFP, which the FDA approved as a biomarker. Therefore, the fucosylation of protein X is expected to have potential as a liver cancer biomarker.
Kim, Jiyoung,Lee, Kyung-Ja,Park, Kyung-Ran,Ha, Boram,Kim, Yi-Jun,Jung, Wonguen,Lee, Rena,Kim, Seung Cheol,Moon, Hye Sung,Ju, Woong,Kim, Yun Hwan,Lee, Jihae The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.4
Purpose: The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma. Materials and Methods: The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who underwent adjuvant radiotherapy following surgery between March 2000 and April 2014. Of these, 25 received postoperative VB alone, while 18 received postoperative EBRT to the whole pelvis; 3 of these were treated with EBRT plus VB. The median EBRT dose was 50.0 Gy (45.0-50.4 Gy) and the VB dose was 24 Gy in 6 fractions. Tumor dose was prescribed at a depth of 5 mm from the cylinder surface and delivered twice per week. Results: The median follow-up period for all patients was 57 months (range, 9 to 188 months). Five-year disease-free survival (DFS) and overall survival (OS) for all patients were 92.5% and 95.3%, respectively. Adjuvant radiotherapy was performed according to risk factors and stage IB, grade 3 and lymphovascular invasion were observed more frequently in the EBRT group. Five-year DFS for EBRT and VB alone were 88.1% and 96.0%, respectively (p = 0.42), and 5-year OS for EBRT and VB alone were 94.4% and 96%, respectively (p = 0.38). There was no locoregional recurrence in any patient. Two patients who received EBRT and 1 patient who received VB alone developed distant metastatic disease. Two patients who received EBRT had severe complications, one each of grade 3 gastrointestinal complication and pelvic bone insufficiency fracture. Conclusion: Adjuvant radiotherapy achieved high DFS and OS with acceptable toxicity in stage I endometrial cancer. VB (with a lower dose per fraction) may be a viable option for selected patients with early-stage endometrial cancer following surgery.
ENSO and IOD Teleconnection Impact on the Interannual Variability of the West Antarctic Sea Ice
Jihae Kim,Daehyun Kang,Myong-In Lee 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10
The El Niño-Southern Oscillation (ENSO) and Indian Ocean dipole (IOD) are well-known climate variabilities in the tropics that have the potential to affect the Antarctic sea ice during Austral spring (September-October-November, SON). The variation in sea ice concentration (SIC) is especially pronounced in the West Antarctic, 20-30% of the total variance of which can be explained by ENSO and IOD during SON. The SIC pattern induced by ENSO and IOD is primarily linked with an anticyclonic circulation anomaly in the Amundsen-Bellingshausen Sea (ABS) that modulates atmospheric poleward temperature advection and longwave radiation forcing via poleward moisture advection. However, it is challenging to determine their separate remote impact on Antarctic sea ice due to a strong correlation coefficient between ENSO and IOD. To isolate the role of each climate mode in the tropical Rossby wave propagation pathways of the southern hemisphere, a tropical nudging experiment was performed using the Geophysical Fluid Dynamics Laboratory (GFDL) atmospheric model. The anticyclonic circulation anomaly in the ABS is primarily contributed by the ENSO-related forcing in the Pacific Ocean, while the contribution of IOD-related forcing in the Indian Ocean is three times weaker. The results of this study imply that atmospheric teleconnection through the southern Pacific Ocean is crucial to the variability of the West Antarctic sea ice.
Kim, Yi-Jun,Lee, Kyung-Ja,Park, Kyung Ran,Kim, Jiyoung,Jung, Wonguen,Lee, Rena,Kim, Seung Cheol,Moon, Hye Sung,Ju, Woong,Kim, Yun Hwan,Lee, Jihae The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.2
Purpose: To analyze prognostic factors for locoregional recurrence (LRR), distant metastasis (DM), and overall survival (OS) in cervical cancer patients who underwent radical hysterectomy followed by postoperative radiotherapy (PORT) in a single institute. Materials and Methods: Clinicopathologic data of 135 patients with clinical stage IA2 to IIA2 cervical cancer treated with PORT from 2001 to 2012 were reviewed, retrospectively. Postoperative parametrial resection margin (PRM) and vaginal resection margin (VRM) were investigated separately. The median treatment dosage of external beam radiotherapy (EBRT) to the whole pelvis was 50.4 Gy in 1.8 Gy/fraction. High-dose-rate vaginal brachytherapy after EBRT was given to patients with positive or close VRMs. Concurrent platinum-based chemoradiotherapy (CCRT) was administered to 73 patients with positive resection margin, lymph node (LN) metastasis, or direct extension of parametrium. Kaplan-Meier method and log-rank test were used for analyzing LRR, DM, and OS; Cox regression was applied to analyze prognostic factors. Results: The 5-year disease-free survival was 79% and 5-year OS was 91%. In univariate analysis, positive or close PRM, LN metastasis, direct extension of parametrium, lymphovascular invasion, histology of adenocarcinoma, and chemotherapy were related with more DM and poor OS. In multivariate analysis, PRM and LN metastasis remained independent prognostic factors for OS. Conclusion: PORT after radical hysterectomy in uterine cervical cancer showed excellent OS in this study. Positive or close PRM after radical hysterectomy in uterine cervical cancer correlates with poor prognosis even with CCRT. Therefore, additional treatments to improve local control such as radiation boosting need to be considered.