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RISS 인기검색어
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- 저자 : Kenneth Shroyer (검색결과 1 건)
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Telomerase Expression in Precancerous Oral Verrucous Hyperplasia
Greer, Robert O.,George Hoernig,Kenneth Shroyer Korean Academy of Oral Biology and the UCLA Dental 1999 International Journal of Oral Biology Vol.24 No.2
Activation of telomerase and stabilization of telomeres are thought to be required for both cellular immortality and oncogenesis. Telomerase is an essential ribonucleoprotein that maintains telomere length and whose activity is associated with escape from cellular senescenec. Telomeres have been purported to function as mitotic clocks, shortening with age in a replication dependent manner. The role of telomerase in oral dysplastic lesions has not been well defined. The purpose of this study is to investigate the role of telomerase in the precancerous dysplastic lesion verrucous hyperplasia. Using a modifies PCR-based assay for telomerase activity, 23 cases of verrucous hyperplasia were examined using a telomertric repeat amplification protocol (TRAP assay). Telomerase positive controls included enzyme abstracts from HELA cells, a squamous cell carcinoma cell line. Negative controls included RNAse pretreatment of tissue extracts. Fresh tissue samples from 23 cases of verrucous hyperplasia were assayed. Telomerase activity was detectable in 14 of 23 cases. Negative controls which included cheek biting leukoplakias failed to demonstrated telomerase activity. This study suggests that telomerase activation may indeed be associated with a precancerous phase of oral squamous cell carcinoma known as verrucous leukoplakia and that telomerase may serve as a biomarker for cancer risk assessment in patients with certain oral precancers.
RISS
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