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Peptides from Bombyx Fibroin Counter D-Galactose-induced Hair Aging in Mice
Yamamoto, Kei-Ichiro,Tsushima, Masaaki,Yoshida, Atsushi,Karimazawa, Mayumi,Nagasuna, Osamu,Uchidate, Michimasa,Iwabuchi, Akira,Goryo, Masanobu,Yamashita, Tetsuro,Suzuk, Koichi Korean Society of Sericultural Science 2011 International Journal of Industrial Entomology Vol.23 No.2
Using proteases, we produced a peptide mixture from fibroin of the silkworm $Bombyx$ $mori$. Mice received D-galactose by subcutaneous injection for 8 weeks to accelerate aging, and then received the peptide mixture orally for 7 weeks. In the mice aged with D-galactose, the coefficient of friction of hair increased significantly up to 1.6-fold, but in the mice subsequently given the peptide mixture, it was normal. Scanning electron microscopy showed improved hair cuticles in the latter mice too. These results indicate that oral administration with peptides from $Bombyx$ fibroin counters the aging of hair cuticles.
Research Articles : Peptides from Bombyx Fibroin Counter D-Galactose-induced Hair Aging in Mice
( Kei Ichiro Yamamoto ),( Masaaki Tsushima ),( Atsushi Yoshida ),( Mayumi Karimazawa ),( Osamu Nagasuna ),( Michimasa Uchidate ),( Akira Iwabuchi ),( Masanobu Goryo ),( Tetsuro Yamashita ),( Koichi Su 한국잠사학회 2011 International Journal of Industrial Entomology Vol.23 No.2
Using proteases, we produced a peptide mixture from fibroin of the silkworm Bombyx mori. Mice received D-galactose by subcutaneous injection for 8 weeks to accelerate aging, and then received the peptide mixture orally for 7 weeks. In the mice aged with D-galactose, the coefficient of friction of hair increased significantly up to 1.6-fold, but in the mice subsequently given the peptide mixture, it was normal. Scanning electron microscopy showed improved hair cuticles in the latter mice too. These results indicate that oral administration with peptides from Bombyx fibroin counters the aging of hair cuticles.