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Takanori Yamada,박규진,Junichi Node,Kakeru Ozaki,Manami Hiraiwa,Yuka Kitaguchi,Katsuyuki Kaneda,Shigeru Hiramoto,Eiichi Hinoi 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.4
An imbalance in the sophisticated regulationbetween bone-resorbing osteoclasts and bone-formingosteoblasts leads to the pathogenesis and etiology of certainmetabolic bone diseases including osteoporosis. Certainpolyamines are related to the pathophysiology of some disorders,including Alzheimer’s disease, infectious disease,cancer, and aging. Recently, we demonstrated that oralintake of polyamines (spermidine and spermine) preventedbone loss through preferential disturbance of osteoclasticactivation in ovariectomy-induced mouse model of postmenopausalosteoporosis. Here, we showed that daily oralsupplementation of a diet containing polyamine-rich Saccharomycescerevisiae S631 significantly inhibited osteoclasticactivation as well as reduction of bone volume in thecancellous bone without affecting uterine weight inovariectomized mice. Our findings recommend that dailyoral supplementation with polyamine-rich yeast diet wouldbe beneficial for prophylaxis of metabolic bone diseasesassociated with abnormal osteoclast activation.