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Park, Je-Kyun,Suh, Kahp-Yang Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.1
<P>Graphic Abstract</P><P>Shooting for another success like the microelectronics industry—Guest Editors Je-Kyun Park and Kahp-Yang Suh highlight the contribution of Korean research to micro and nanofluidics. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0lc90085k'> </P>
Suh, Kahp-Yang,Park, Min Cheol,Kim, Pilnam WILEY-VCH Verlag 2009 Advanced Functional Materials Vol.19 No.17
<P>This Feature Article aims to provide an in-depth overview of the recently developed molding technologies termed capillary force lithography (CFL) that can be used to control the cellular microenvironment towards cell and tissue engineering. Patterned polymer films provide a fertile ground for controlling various aspects of the cellular microenvironment such as cell–substrate and cell–cell interactions at the micro- and nanoscale. Patterning thin polymer films by molding typically involves several physical forces such as capillary, hydrostatic, and dispersion forces. If these forces are precisely controlled, the polymer films can be molded into the features of a polymeric mold with high pattern fidelity and physical integrity. The patterns can be made either with the substrate surface clearly exposed or unexposed depending on the pattern size and material properties used in the patterning. The former (exposed substrate) can be used to adhere proteins or cells on pre-defined locations of a substrate or within a microfluidic channel using an adhesion-repelling polymer such as poly(ethylene glycol) (PEG)-based polymer and hyaluronic acid (HA). Also, the patterns can be used to co-culture different cells types with molding-assisted layer-by-layer deposition. In comparison, the latter (unexposed substrate) can be used to control the biophysical surrounding of a cell with tailored mechanical properties of the material. The surface micropatterns can be used to engineer cellular and multi-cellular architecture, resulting in changes of the cell shape and the cytoskeletal structures. Also, the nanoscale patterns can be used to affect various aspects of the cellular behavior, such as adhesion, proliferation, migration, and differentiation.</P> <B>Graphic Abstract</B> <P>An in-depth overview of the recently developed molding technology termed capillary force lithography (CFL) that can be used to control the cellular microenvironment is presented in this Feature Article. If physical forces such as capillary, hydrostatic, and dispersion forces are precisely controlled, polymer films can be molded into the features of a polymeric mold with high pattern fidelity and physical integrity. The molding methods presented here can be used to create a structured biomaterials interface as an experimental platform for better understanding cell–substrate interactions in cell biology and tissue-engineering applications. <img src='wiley_img/1616301X-2009-19-17-ADFM200900771-content.gif' alt='wiley_img/1616301X-2009-19-17-ADFM200900771-content'> </P>
Soft lithographic patterning of proteins and cells inside a microfluidic channel
Kahp-Yang Suh(서갑양) 한국진공학회(ASCT) 2007 Applied Science and Convergence Technology Vol.16 No.1
마이크로유체 채널 내에서 표면 성질과 기능성 분자들의 공간적인 위치를 제어하는 것은 진단소자, 마이크로 반응기, 또는 세포와 마이크로 유체역학의 기본적인 연구를 위해 매우 중요하다. 이 논문에서는 소프트 리소그라피 방법을 이용하여 채널 안에 패턴된 구조물을 포함하는 안정적인 마이크로 채널을 제작하는 방법을 소개하려 한다. 먼저 패턴된 영역을 폴리디메틸실록세인(PDMS) 몰드의 치수와 제작 과정을 적당히 조절함으로써 산소 플라즈마로부터 보호한다. 마이크로 구조물은 대표적인 생물오손(biofouling) 억제 물질인 폴리에틸렌 글리콜(PEG)계 공중합 고분자 혹은 다당류인 히알루산(HA)을 패턴하여 얻었으며 이러한 패턴을 이용하여 피브로넥틴(FN), 소의 혈장 알부민(BSA) 등의 단백질과 동물 세포의 어레이를 제작하였다. The control of surface properties and spatial presentation of functional molecules within a microfluidic channel is important for the development of diagnostic assays, microreactors, and for performing fundamental studies of cell biology and fluid mechanics. Here, we present soft lithographic methods to create robust microchannels with patterned microstructures inside the channel. The patterned regions were protected from oxygen plasma by controlling the dimensions of the poly(dimethylsiloxane) (PDMS) mold as well as the sequence of fabrication steps. The approach was used to pattern a non-biofouling polyethylene glycol (PEG)-based copolymer or the polysaccharide hyaluronic acid (HA) within microfluidic channels. These non-biofouling patterns were then used to fabricate arrays of fibronectin (FN) and bovine serum albumin (BSA) as well as mammalian cells.
2 단계 모세관 리소그라피 기술을 이용한 마이크로/나노스케일 복합 구조의 제조 및 표면 특성 분석
서갑양(Kahp Yang Suh),정훈의(Hoon Eui Jeong),이성훈(Sung Hun Lee),김재관(Jae Kwan Kim) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
In this paper, a simple method for fabricating micro/nanoscale combined hierarchical structures is presented using a two-step temperature-directed capillary molding technique. This lithographic method consists of two steps: (ⅰ) fabrication of polymer microstructures using a PDMS mold and (ⅱ) subsequent nanofabrication using a high-resolution polyurethane acrylate (PUA) mold on top of the pre-formed microstructures. The resulting micro/nano combined structures were robust and demonstrated enhanced water-repellent properties by coexistence of homogeneous and heterogeneous wettings, as confirmed by contact angle measurement of water. An analytical model was suggested to explain our experimental observations and shows a good agreement with the experimental results.
Soft lithographic patterning of proteins and cells inside a microfluidic channel
서갑양,Suh, Kahp-Yang The Korean Vacuum Society 2007 Applied Science and Convergence Technology Vol.16 No.1
The control of surface properties and spatial presentation of functional molecules within a microfluidic channel is important for the development of diagnostic assays, microreactors, and for performing fundamental studies of cell biology and fluid mechanics. Here, we present soft lithographic methods to create robust microchannels with patterned microstructures inside the channel. The patterned regions were protected from oxygen plasma by controlling the dimensions of the poly(dimethylsiloxane)(PDMS) mold as well as the sequence of fabrication steps. The approach was used to pattern a non-biofouling polyethylene glycol(PEG)-based copolymer or the polysaccharide hyaluronic acid(HA) within microfluidic channels. These non-biofouling patterns were then used to fabricate arrays of fibronectin(FN) and bovine serum albumin(BSA) as well as mammalian cells. 마이크로유체 채널 내에서 표면 성질과 기능성 분자들의 공간적인 위치를 제어하는 것은 진단소자, 마이크로 반응기, 또는 세포와 마이크로 유체역학의 기본적인 연구를 일해 매우 중요하다. 이 논문에서는 소프트 리소그라피 방법을 이용하여 채널 안에 패턴된 구조물을 포함하는 안정적인 마이크로 채널을 제작하는 방법을 소개하려 한다. 먼저 패턴된 영역을 폴리디메틸실록세인(PDMS) 몰드의 치수와 제작 과정을 적당히 조절함으로써 산소 플라즈마로부터 보호한다. 마이크로 구조물은 대표적인 생물오손(biofouling) 억제 물질인 폴리에틸렌 글리콜(PEG)계 공중합 고분자 혹은 다당류인 히알루산(HA)을 패턴하여 얻었으며 이러한 패턴을 이용하여 피브로넥틴(FN), 소의 혈장 알부민(BSA) 등의 단백질과 동물 세포의 어레이를 제작하였다.