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RISS 인기검색어
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- 저자 : K.Y. Sara Lee (검색결과 4 건)
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H.C. Alexander Chee,R.S.K. Singh,K.Y. Sara Lee 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.4
The effect of small amounts (0.2 wt% and 0.5 wt%) of transition metal oxide (CuO) doping on the sintering behavior of 3mol% yttria-stabilized zirconia (Y-TZP) was investigated over the temperature range of 1250 oC to 1500 oC. Sintered sampleswere characterized to determine the phase present, relative density, microstructural evolution and Vickers hardness. Thestudies revealed that the addition of 0.2 wt% CuO dopant was most effective in enhancing the densification of the Y-TZP inparticularly at low temperatures below 1350 oC. The phase analysis revealed that the tetragonal phase was disrupted as evidentfrom the high monoclinic phase formation in the 0.5 wt% CuO-doped zirconia. This phenomenon was associated withmechanism involving transient liquid phase which believed to have destabilized the tetragonal structure. Nevertheless, thestudy revealed that compared to the undoped Y-TZP, the sample with addition of 0.2 wt% CuO resulted in enhanced hardnessand finer grain sizes when sintered at relatively low temperatures.
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Characterization of forsterite ceramics
K.Y. Sara Lee 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.1
In the present study, phase pure forsterite was obtained in sintered bodies from powder mixtures that did not undergo a heat treatment process prior to sintering. This is contrary to the practice reported in the literature where the powder mixture is normally subjected to a heat treatment at about 1200 ο C prior to sintering process. The present results revealed that pure forsterite could be obtained after sintering the powder mixture above 1300 ο C. The study found that the mechanical properties of forsterite increased with increasing sintering temperature. A maximum Vickers hardness and fracture toughness of 7.68 GPa and 5.16 MPam1/2 were measured for samples sintered at 1500 ο C.
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K.W. Goh,Y.H. Wong,R.S.K. Singh,Hari Chandran,S.K. Wong,K.Y. Sara Lee 한양대학교 세라믹연구소 2022 Journal of Ceramic Processing Research Vol.23 No.2
The extraction of calcium from natural biowaste material such as chicken eggshells have been shown to be viable to synthesiscalcium phosphate bioceramic. In this work, eggshell-derived hydroxyapatite powder was synthesised by using the wetchemical precipitation technique coupled with microwave irradiation at low power (700 W) at varying exposure time from 5to 30 min. The derived nano-powders were examined to determine the phases present, chemical bonding and microstructuralevolution. It was revealed that the irradiation time has an effect on the degree of crystallinity and both the crystallite andparticle size of the derived powders although the hydroxyapatite phase stability was not disrupted. An exposure time of 15 min. was determined to be sufficient when subjected to low power microwave irradiation to formed a well-defined needle-likehydroxyapatite particles having an average crystallite size of about 22 nm. On the contrary to many literatures, this study hasdemonstrated the viability of synthesizing a useful bioceramic from using biowaste eggshells coupled with microwaveirradiation at low power of 700 W for very short period of time to produce nano-range needle-like hydroxyapatite particlessuitable for biomedical application.
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S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis
Yi, S.,Um, S.,Lee, J.,Yoo, J.,Bang, S.,Park, E.,Lee, M.,Nam, K.,Jeon, Y.,Park, J.,You, J.,Lee, S.J.,Bae, G.U.,Rhie, J.,Kozma, Sara C.,Thomas, G.,Han, J.W. Cell Press 2016 Molecular Cell Vol.62 No.3
S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity. Critical among these is the control of a transcriptional program required for the commitment of mesenchymal stem cells to the adipocytic lineage. However, in contrast to its role in the cytosol, the functions and targets of nuclear S6K1 are unknown. Here, we show that adipogenic stimuli trigger nuclear translocation of S6K1, leading to H2BS36 phosphorylation and recruitment of EZH2 to H3, which mediates H3K27 trimethylation. This blocks Wnt gene expression, inducing the upregulation of PPARγ and Cebpa and driving increased adipogenesis. Consistent with this finding, white adipose tissue from S6K1-deficient mice exhibits no detectable H2BS36 phosphorylation or H3K27 trimethylation, whereas both responses are highly elevated in obese humans or in mice fed a high-fat diet. These findings define an S6K1-dependent mechanism in early adipogenesis, contributing to the promotion of obesity.
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