Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

양 족부 열감을 호소하는 하지불안증후군 환자 치험 1례

김경묵,서원주,김수빈,정우상,문상관,권승원,조기호,Kim, Gyeong-muk,Suh, Won-joo,Kim, Su-bin,Jung, Woo-sang,Mun, Sang-kwan,Kwon, Seung-won,Cho, Ki-ho 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.2

Objectives: The purpose of this study is to evaluate the effectiveness of electroacupuncture on heat sensation of the feet of a 61-year-old female patient with restless leg syndrome. Methods: Electroacupuncture was performed at four acupoints (KI3 (太谿), KI6 (照海), LR3 (太衝), LR2 (行間)) selected to reduce heat sensation in both feet. The patient's symptoms were assessed using the VAS (Visual Analogue Scale), the SF-MPQ (short-form McGill Pain Questionnaire), and the IRLS (International Restless Legs Scale). The treatment was performed from April 20, 2010 to April 24, 2010. Results: During five sessions of electroacupuncture treatments, the VAS, SF-MPQ, and IRLS scores improved throughout the treatment period and afterwards. Conclusions: The results suggest that electroacupuncture at KI3(太谿), KI6(照海), LR3(太衝), LR2(行間) can be effective for reducing hot flush in both feet.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

폐렴으로 병발된 범발성 혈관내 응고증의 Antithrombin III 치험 1례

서중산,최호열,김현수,이록윤,오흥국,박영석,정기석,박근칠,선덕제 한림대학교의료원 1994 人間科學 Vol.18 No.9

브러시리스 DC 모터의 코킹토크 저감 대책

서기영,이현우,문상필,강욱중 慶南大學校 附設 工業技術硏究所 1999 硏究論文集 Vol.17 No.-

본 연구에서는 정밀, 소형제동에 사용되는 브러시리스 DC모터의 정밀 운전시 문제가 되는 코킹 토크의 저감을 위하여 코킹 토크 형성에 관한 특정식을 유도하여 그 성질을 파악하고 특정식을 토대로 코킹 토크저감을 위한 설계법을 제안하였다. The Paper characteristics equation of cogging torque is induced to learn this characteristics and on the ground of this equation, the design method is proposed for reducing cogging torque which is the problem to precisely drive DC brushless motor used in precise control system.

인라인 스케이트 활동이 정신지체아의 운동기능 향상에 미치는 효과

서연태,정기천 한국유아체육학회 2002 한국유아체육학회지 Vol.3 No.-

이 연구의 목적은 인라인 스케이트 활동을 통하여 정신지체 아동들의 운동기능 향상에 미치는 효과를 알아보기 위한 것이었다. 연구대상은 교육가능급 12명, 훈련가능급 12명 총 24명이었으며, 인라인 스케이트 프로그램은 연구자가 직접 구성하였다. 평가표는 착용동작, 걷기동작, 달리기동작으로 구분하여 연구가가 직접 제작하였다. 신뢰도 검증은 Cronbach's-a 방법을 사용하였다. 자료처리는 SPSS/PC+ 프로그램 10.0을 이용하였으며, 평균차를 검증하기 위하여 Paired-Sample T-test를 실시하였다. 유의수준은 .05로 하였다. 이 연구의 결론은 다음과 같다. 첫째, 교육가능급 및 훈련가능급 정신지체 아동의 운동기능 비교에서는 착용동작, 걷기동작, 달리기동작에 있어서 모두 교육가능급이 훈련가능급보다 높았다. 둘째, 교육가능급 정신지체 아동의 동작별 사전·사후 비교에서 정신지체 아동의 운동 기능 중 착용동작(P<.001), 걷기동작(P<.001), 달리기동작(P<.001) 모두 유의한 차이를 보였다. 셋째, 훈련가능급 정신지체 아동의 동작별 사전·사후 비교에서 정신지체 아동의 운동 기능 중 착용동작(P<.001) 걷기동작(P<.001), 달리기동작(P<.001) 모두 유의한 차이를 보였다. This study aims to examine effects of in-line skates program on improvement of motor skills of mentally retarded children. The subjects were 24 (trainable 12, educable 12) mentally retarded children of one MR Sports Center in Seoul. The children were observed by the researchers according to the checklist prepared with the two points. The motor skill was checked in 3 skill-phases; wearing, walking, running. Cronbach's-Alpha-method was used for verifying reliability of the facotrs. The data were tested (p〈.05) by paired t-test. The results of this study were as follows: 1. The educable mentally retarded children showed better motor skills than the trainable in all the phases (wearing, walking, running). 2. In the posttest the educable mentally retarded children showed significant improvement in all the skills (wearing, walking, running) in comparison with the pretest (p〈.001). 3. In the posttest the trainable mentally retarded children showed significant improvement in all the skills (wearing, walking, running) in comparison with the pretest (p〈.001).

운동시 젖산대사의 변화 : 젖산수송체의 발현 monocarboxylate transporters and its implication

임기원,서혜정,이강우 한국운동영양학회 2001 Physical Activity and Nutrition (Phys Act Nutr) Vol.5 No.2

Skeletal muscle is the major producer of lactate in tissues, however its oxidative fibres also use lactate as a oxidative fuel. The stereoselective transport of L-lactate across the plasma membrane of muscle fibres has been shown to involve a proton-linked monocarboxylate transporter (MCT) similar to that described in erythrocytes, heart and skeletal muscle. This transporter plays an important role in the pH regulation of skeletal muscle. A family of eight MCTs has now been cloned and sequenced, and the tissue distribution of each isoform varies. Skeletal muscle contains both MCT1 (the only isoform found in erythrocytes but also present in most other cells) and MCT4. The latter is found in all fibre types, although least in more oxidative red muscles such as soleus, whereas expression of MCT1 is highest in the more oxidative muscles and very low in white muscles that are almost entirely glycolytic. MCT1 expression is increased in response to chronic stimulation and either endurance or explosive exercise training in rats and humans, both MCT1 and MCT4. The mechanism of regulation is not established, but does not appear to be accompanied by changes in mRNA concentrations. The increase of MCT1 protein by chronic or acute training in oxidative muscle could depend on exercise intensity, because more higher intensity could increase MCT1 protein. These facts suggest that high oxidative capacity for lactate in skeletal muscle would require to more higher exercise intensity, as well as above lactate threshold.

여성 청각 ·언어장애인의 취업욕구에 관한 조사 연구 : 부산 ·경남지역을 중심으로

김기태,박병현,서화정 釜山大學校 社會福祉硏究所 1999 社會福祉硏究 Vol.9 No.-

석유화학공업 종사자의 유전독성 위험성 평가

안기원,박정선,서순팔,문재동,조진형 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

In order to evaluate the genotoxic hazard among workers potentially exposed to low level petrochemical substances, the analyses of micronuclei(MN) and sister chromatid exchanges(SCEs) in lymphocytes were performed in 46 male workers(as exposed group) and 46 nonexposed subjects(as control group). Mean frequencies of MN and SCEs(respectively, 12.9/1000 cells and 6.5/cell) in exposed group were very significantly higher than those(10.2/1000 cells and 5.4/cell) in control group. And there were also significant differences in mean frequencies of MN and SCEs adjusted for age, employment duration, smoking, and drinking between two groups. Median frequencies of MN and SCEs in exposed group were very significantly higher than those in control group. Frequencies of SCEs were higher in smokers than in non-smoker. Frequencies of MN in smokers, however, were similiar to those of non-smoker. Interaction between exposure and smoking on MN and SCEs induction was not observed. The results suggest that there is genotoxic hazard in high risk group like workers handling carcinogens in petrochemical plants and the analyses of MN and SCEs are useful biomarkers for the exposure to hazard substances even at the level below the exposure limit.

한국 성인의 Campylobacter pylori항체에 관한 연구

김기호,김정목,조양자,서인수 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.2

Campylobacter pylori (C. pylori) that had recently been reported have becom an interesting objects in the discussion of the etiology of gastritis and peptic ulcer. The role of the C. pylori was evaluated in groups of adults with pathologic mucosa and with normal mucosa, who visited to Hanyang University Hospital in Seoul, Korea. By means of culture or Warthin-Starry silver stain, C. pylori was detected in biopsy materials of 53 (68.8%) out of 77 patients and 1 (7.7%) out of 13 concurrent control subjects (p<0.05). According to the histopathologic gradings, the following numbers were to be positive: active chronic gastritis 41 (75.9%); chronic gastritis 7 (13.0%); chronic ulcer 5 (9.3%); and histologically normal findings 1 (1.9%). A serological screening that used for a dot immunoassay resulted in the following reports: positive Ig G immunoblot were found in 51 (94.4%) of the patients with C. pylori and in 11 (20.4%) of the patients without C. pylori (p<0.01); and positive Ig A immunoblot were found in 11 (20.4%) of the patients with C. pylori and in zero (0.0%) of the patients without C. pylori (p<0.05). A serologic test used for a Western blot immunoassay resulted in seven strong protein bands (108 KD, 98 KD, 78 KD, 72 KD, 68 KD, and 62 KD). These findings strongly implicate C. pylori as one of the cause of active chronic gastritis and chronic ulcer. And this study supports the concept that C. pylori may be an important cause of gastritis or peptic ulcer in Korean adults.